Evidence That an<i>HMGA1</i>Gene Variant Associates with Type 2 Diabetes, Body Mass Index, and High-Density Lipoprotein Cholesterol in a Hispanic-American Population

PullingerClive, R; GoldfineIra, D; TanyolaçSinan,; MovsesyanIrina,; FaynboymMark,; DurlachVincent,; Chiefari, Eusebio; Foti, Daniela; FrostPhilip, H; MalloyMary, J; Brunetti, Antonio; KaneJohn, P

doi:10.1089/met.2013.0086

Cited by 46 publications

(47 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genetic and biologic differences are associated with susceptibility to increased fibrosis and inflammation in NAFLD, NASH and HCV, influencing more aggressive cirrhosis progression and hepatocarcinogenesis[48-50,54-56]. Racial and ethnic differences modulating insulin resistance have also been identified; compared to non-Hispanics, Hispanics express a higher frequency of an insulin receptor gene regulator (high-mobility group AT-hook, or HMGA1) associated with higher BMI, lower HDL, and type 2 diabetes[57]. While our study did not include biologic correlates, given the paucity of Hispanic specific information, studies comparing Hispanic tumor and cirrhosis samples to other multi-ethnic HCC and cirrhotic cohorts are necessary to better understand ongoing racial disparities in HCC and cirrhosis mortality and progression.…”

Section: Discussionmentioning

confidence: 99%

Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

Venepalli

Modayil

Berg

et al. 2017

WJH

View full text Add to dashboard Cite

AIMTo compare features of hepatocellular carcinoma (HCC) in Hispanics to those of African Americans and Whites.METHODSPatients treated for HCC at an urban tertiary medical center from 2005 to 2011 were identified from a tumor registry. Data were collected retrospectively, including demographics, comorbidities, liver disease characteristics, tumor parameters, treatment, and survival (OS) outcomes. OS analyses were performed using Kaplan-Meier method.RESULTSOne hundred and ninety-five patients with HCC were identified: 80.5% were male, and 22% were age 65 or older. Mean age at HCC diagnosis was 59.7 ± 9.8 years. Sixty-one point five percent of patients had Medicare or Medicaid; 4.1% were uninsured. Compared to African American (31.2%) and White (46.2%) patients, Hispanic patients (22.6%) were more likely to have diabetes (P = 0.0019), hyperlipidemia (P = 0.0001), nonalcoholic steatohepatitis (NASH) (P = 0.0021), end stage renal disease (P = 0.0057), and less likely to have hepatitis C virus (P < 0.0001) or a smoking history (P < 0.0001). Compared to African Americans, Hispanics were more likely to meet criteria for metabolic syndrome (P = 0.0491), had higher median MELD scores (P = 0.0159), ascites (P = 0.008), and encephalopathy (P = 0.0087). Hispanic patients with HCC had shorter OS than the other racial groups (P = 0.020), despite similarities in HCC parameters and treatment.CONCLUSIONIn conclusion, Hispanic patients with HCC have higher incidence of modifiable metabolic risk factors including NASH, and shorter OS than African American and White patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

Venepalli

Modayil

Berg

et al. 2017

WJH

View full text Add to dashboard Cite

show abstract

“…HMGA proteins participate in a wide variety of normal physiological processes including: chromatin and nucleosome remodeling, regulation of gene transcription, cell growth and cycle regulation, involvement in embryonic development, regulation of body size, control of height and weight as well as involvement in cellular aging and senescence [15,85,[90][91][92][93][94][95]. Aberrant-or over-expression of HMGA proteins is also associated with many pathological conditions including cancer initiation and progression [13,96,97], diabetes [98][99][100], obesity [101,102] and Alzheimer's disease [103][104][105][106], to mention a few.…”

Section: The Hmga Familymentioning

confidence: 99%

“…This idea has, indeed, been demonstrated to be correct but with each sub-family of proteins showing distinctive differences in their effects on development. For example, both Hmga1 −/− and heterozygous (Hmga1 +/− ) mice are of normal size but exhibit cardiac hypertrophy [114] and insulin resistant type 2 diabetes [99,100,115,116] and are prone to myelo-lymphoproliferative disorders. These findings suggest that appropriate levels of HMGA1 protein are required for both cardomyocyte cell growth [114] and for regulating the glucose uptake and insulin pathways [99,116].…”

Section: The Hmga Familymentioning

confidence: 99%

High mobility group (HMG) proteins: Modulators of chromatin structure and DNA repair in mammalian cells

Reeves

2015

DNA Repair

View full text Add to dashboard Cite

“…In the Middle East, diabetes is also prevalent, mirroring the current global epidemic of diabetes [3] . The high prevalence of obesity and lack of exercise, along with the possibility of regionspecific genetic mutation associated with diabetes, may be the explanation, thereby further confirming the genetic peculiarity of some populations [4,5] .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Diabetic Nephropathy among Type 2 Diabetes Mellitus, and Glycaemic Control Evaluated by Glycaeted Haemoglobin in Diabetic Patients with and without Diabetic Nephropathy

Al-Gefri¹,

Baalwi

2019

The Medical Journal of Cairo University

View full text Add to dashboard Cite

Background: Diabetic Nephropathy (DN) is by far the most common cause of End-Stage Renal Disease (ESRD). Approximately one-third of individuals with diabetes develop DN, with a high likelihood of progression to ESRD. In addition, DN is associated with considerably increased cardiovascular disease risk and mortality. Aim of Study: The purpose of this study is to determine the prevalence of diabetic nephropathy between T2DM, and glycaemic control evaluated by a glycaeted haemoglobin in diabetic patients with and without diabetic nephropathy. Material and Methods: This study was carried out on 100 diabetic patients who attended a private clinic in Aden-Yemen. Over a period from 1 st June 2018 to 1 st January 2019. All the participants studied were subjected to assessment of sex, age and duration of diabetes with laboratory investigations including determination of urinary albumin to creatinine ratio, and glycated haemoglobin (HbA 1 c). Results: The results showed that 14% of all patients have been studied had diabetic nephropathy, there were statistically significant relationships between diabetic nephropathy and duration of diabetes (p=0.040), there were no statistically significant relationships between diabetic nephropathy and age, sex and glycated haemoglobin level (HbA 1 c) of the patients. Conclusion: Screening for microalbuminuria will enable early identification of patients with DN. Duration of DM and was strong predictor associated with the development of DN in the patients studied. This also raises a red flag against the common medical practice of only using Serum Creatinine as a test to determine renal function.

show abstract

Evidence That anHMGA1Gene Variant Associates with Type 2 Diabetes, Body Mass Index, and High-Density Lipoprotein Cholesterol in a Hispanic-American Population

Abstract: As we saw previously among white Europeans, a functional HMGA1 variant was associated with T2DM in individuals of Hispanic-American ethnicity and was present at a much higher frequency.

Cited by 46 publications

References 26 publications

Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites

High mobility group (HMG) proteins: Modulators of chromatin structure and DNA repair in mammalian cells

Prevalence of Diabetic Nephropathy among Type 2 Diabetes Mellitus, and Glycaemic Control Evaluated by Glycaeted Haemoglobin in Diabetic Patients with and without Diabetic Nephropathy

Contact Info

Product

Resources

About