Evidence that Chlamydia pneumoniae Causes Pneumonia and Bronchitis

Grayston, J. T.; Aldous, M. B.; Easton, Andrew J.; Wang, San-Pin; Kuo, Cho‐Chou; Campbell, Lee Ann; Altman, J.

doi:10.1093/infdis/168.5.1231

Cited by 250 publications

(144 citation statements)

References 17 publications

Supporting

Mentioning

137

Contrasting

Unclassified

Order By: Relevance

“…Chlamydia pneumoniae is an intracellular pathogen [1,2] that has recently been associated with chronic airway diseases such as asthma. Acute C. pneumoniae infection can cause exacerbation of asthma [3], and chronic/persistent infection has been linked to chronic persistent asthma, and adult onset asthma [4].…”

mentioning

confidence: 99%

Chlamydia pneumoniaeimmunoglobulin A reactivation and airway inflammation in acute asthma

Wark

Johnston²,

Simpson³

et al. 2002

Eur Respir J

View full text Add to dashboard Cite

Infection with Chlamydia pneumoniae can trigger acute asthma and is associated with severe chronic asthma. The aim of the present study was to examine the relationship between airway inflammation and serological response to C. pneumoniae in acute severe asthma.Subjects (n=54) were recruited within 4 h of presentation to the emergency department with an acute exacerbation of asthma. Clinical history taking, sputum induction (0.9% saline), spirometry and acute and convalescent serology for C. pneumoniae immunoglobulins A and G were performed.At presentation, 47% of subjects had antibodies directed against C. pneumoniae, and 38% (20) demonstrated an increase in C. pneumoniae antibody levels, with 15 demonstrating a rise in immunoglobulin A concentration. C. pneumoniae responders exhibited significantly higher sputum neutrophil levels (4.6610 6 cells?mL -1 ) compared to nonresponders (1.2610 6 cells?mL -1 , p=0.02) and elevated sputum eosinophil cationic protein concentration (3,981 versus 1,122 ng?mL -1 , p=0.02). An acute antibody response to Chlamydia pneumoniae is common in exacerbations of asthma. The serological features suggest that Chlamydia pneumoniae reactivation may trigger neutrophilic airway inflammation in acute asthma. Eur Respir J 2002; 20: 834-840.

show abstract

mentioning

confidence: 99%

Chlamydia pneumoniaeimmunoglobulin A reactivation and airway inflammation in acute asthma

Wark

Johnston²,

Simpson³

et al. 2002

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…In a series of studies 10% of cases of pneumonia and approximately 5% of bronchitis and sinusitis cases in adults have been attributed to the organism 16 .No set of symptoms or signs is unique to pulmonary infections with C. pneumoniae; however, several characteristics of the clinical presentation may help distinguish it from other causes . 17 A subacute onset is common. Pharyngitis, sometimes with hoarseness, is often present early in the course of the illness.…”

Section: Lymphogranuloma Venereum (Lgv)mentioning

confidence: 99%

Insights into the Biology, Infections and Laboratory Diagnosis of Chlamydia

Hn¹,

Malathi²,

Bagyalakshmi³

2012

Chlamydia

View full text Add to dashboard Cite

“…12 In primary infection due to C. pneumoniae, 1g M antibodies may take up to 3 weeks to appear and 1 g G antibodies may take upto 8 weeks to appear. 13 Therefore, the absence of detectable antibodies several weeks after infection does not excludes the diagnosis of acute C. pneumoniae infection. Serologic test for legionella in the acute phase of the disease is usually negative and show a low titer 13 if the etiology of a case remains in question, a convalescent -phase serum specimen can be obtained, and paired serological studies can be performed.…”

Section: Serological Testsmentioning

confidence: 99%

Evaluation and Management

Lai

2008

Aortic Arch Surgery

View full text Add to dashboard Cite

Community-Acquired Pneumonia (CAP) is a serious medical problem affecting mostly the young healthy adults, children and elderly population all over the globe and is associated with considerable mortality and morbidity. CAP is the 6th leading cause of death. Millions of people are affected by CAP world over every year from developed to developing countries, most of them needs hospitalized treatment and hence the economic burden on the society is huge. Although diagnostic techniques and antibiotic therapy have improved to a great extent yet optimal management of the disease is still problematic. Lower respiratory tract infection by atypical intracellular pathogens have made the problem of CAP more complicated. This article reviewed the current trends in the evaluation and management of CAP. INTRODUCTIONCommunity acquired pneumonia is defined as pneumonia acquired in the patients home or in non hospital environment being diagnosed within 48 hours of hospital admission. Despite the availability of various diagnostic methods and potent newer antimicrobial agents and effective vaccines CAP occur throughout the globe and stands as the 6th leading cause of death. The mortality rate in hospitalized patients is 14% and in outpatient population is 1% . The morbidity rate is significantly high, lower respiratory tract infection by atypical intracellular pathogens have made the management of CAP more complicated. 1 The disease affects the people of all age group but is more in healthy young adults, children and elderly. Infection is mostly spread by droplet inhalation and most patients affected are previously well. 2 Cigarette smoking, alcoholism, corticosteroid therapy and immune suppression, all impair mucociliary clearance and predispose to infection.The epidemiology of CAP is not clear, because few population based statistics on the condition alone are available. 3 It is estimated that 4 million American adults suffer from CAP each year imposing a significant economic burden on the society with an annual expenditure of approximately 10 million $. 4 The incidence of CAP requiring hospitalization is estimated to be 258 cases per 100,000 population and 926 cases per 100,000 persons > 65 years of age. 5 The incidence of CAP is highest in winter months. EVALUATION ClinicalClinical presentation depends on the micro-biologic agent and host factors such as age, immune status and other comorbid conditions. A detailed history of exposure, travel, hobbies and past medical history is helpful in suggesting a microbiologic etiology. Severity and presenta-tion of CAP ranges from mild to life threatening, although the symptoms may vary. Symptoms of CAP Commonly Include 6• Difficulty in breathing.• Cough that produces yellow or greenish sputum.• Sharp or stabbing chest pain.• High fever that may be accompanied with sweating, chills and uncontrollable shaking.• Rapid, shallow breathing that is often painful. Physical Examination CAP should be suspected in patients with newly acquired lower respiratory symptoms (cough, sput...

show abstract

Evidence that Chlamydia pneumoniae Causes Pneumonia and Bronchitis

Cited by 250 publications

References 17 publications

Chlamydia pneumoniaeimmunoglobulin A reactivation and airway inflammation in acute asthma

Chlamydia pneumoniaeimmunoglobulin A reactivation and airway inflammation in acute asthma

Insights into the Biology, Infections and Laboratory Diagnosis of Chlamydia

Evaluation and Management

Contact Info

Product

Resources

About