Evidence that cisplatin induces serotonin release from human peripheral blood mononuclear cells and that methylprednisolone inhibits this effect

Mantovani, Giovanni; Macciò, Antonio; Esu, S.; Lai, P.

doi:10.1016/0959-8049(96)00204-3

Cited by 11 publications

(7 citation statements)

References 11 publications

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“…Corticosteroids are effective as prophylaxis against CINV, but the mechanisms underlying this effect are still unknown. Results from one in vitro study showed that MP substantially decreased cisplatin-induced 5-HT release from peripheral blood mononuclear cells [12]. The possibility that at least part of the therapeutic benefit of MP arises from its ability to decrease 5-HT release is consistent with the fact that emesis is associated with increased levels of this indoleamine in the gut and brain stem [13].…”

Section: Mechanisms Underlying Corticosteroid Impact On Cinvmentioning

confidence: 87%

Antiemetic activity of corticosteroids in patients receiving cancer chemotherapy: dosing, efficacy, and tolerability analysis

Grunberg

2007

Annals of Oncology

138

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Section: Mechanisms Underlying Corticosteroid Impact On Cinvmentioning

confidence: 87%

Antiemetic activity of corticosteroids in patients receiving cancer chemotherapy: dosing, efficacy, and tolerability analysis

Grunberg

2007

Annals of Oncology

138

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“…It was reported that high total phenolic acid in Tualang honey such as gallic acid [28] was associated with inhibition of histamine release and other pro-inflammatory cytokine production by mast cells in rats [29]. Previous animal and clinical studies have shown that prednisolone suppressed the release of serotonin and histamine during inflammatory conditions [30].…”

Section: Discussionmentioning

confidence: 99%

Preemptive Effects of Administration of Tualang Honey on Inflammatory Responses in Adult Male Rats

Ismail

Hussin

Mohamed

et al. 2017

J. Pharm. Nutr. Sci.

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Background: Honey was reported to reduce pain and inflammation from burn wound. To date, no study has compared between the effects of Tualang honey and prednisolone on inflammatory responses in rats. This study has examined the effects of Tualang honey and prednisolone on inflammatory pain and its associated inflammatory responses secondary to formalin injection. Methods: Twenty-one Sprague-Dawley male rats were randomised into control, Tualang honey (1.2 g/kg) or prednisolone (10 mg/kg) groups. Formalin test was conducted and the rats were sacrificed at four-hours post-formalin injection. Serum was collected for measurement of leukocyte counts and interleukins level. All data were analysed using one-way ANOVA with post-hoc Scheffe's or Dunnet's C test. Significance level was taken as less than 0.05. Results: Tualang honey and prednisolone groups had significantly reduced pain behaviour and paw edema compared to control group. Tualang honey group demonstrated a significant increase in blood neutrophil count while prednisolone group had significant reduction in blood lymphocyte and monocyte counts compared to control group. Only interleukin-6 level was significantly reduced in honey group. Both interleukin-6 and-8 levels were significantly reduced in prednisolone group. Conclusions: Tualang honey is comparable to prednisolone in modulating the inflammatory pain responses in rats; however, with regards to local and systemic inflammatory responses, it has differential effects compared to prednisolone.

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“…Reduced release of 5-HT 3 from blood cells upon administration of steroids as well as direct effects on cellular 5-HT 3 receptor expression have been suggested as important factors. 33,34 Furthermore, preclinical data point to a direct effect of corticosteroids in the medulla oblongata. 35 Steroids are administered either alone or in combination with other drugs.…”

Section: Antiemetic Propertiesmentioning

confidence: 99%

Corticosteroid use in neuro-oncology: an update

Roth

Happold

Weller

2014

Neuro-Oncology Practice

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Because of the lack of curative approaches for most patients with malignant brain tumors, supportive therapy, which aims at maintaining quality of life and functional independence, has a central role in the treatment of many patients. Steroids are particularly important in the setting of supportive therapy. They are commonly used to treat tumor-associated edema, and their administration is typically associated with rapid symptom relief, such as the resolution of headaches. Besides their antiedema activity, corticosteroids are characterized by their potent antilymphoma properties and their effects against acute or delayed emesis caused by systemic chemotherapy in cancer patients. Accordingly, steroids are among the most frequently used drugs in oncology. These desirable properties of steroids are counterbalanced by cardiovascular, muscular, and psychiatric side effects. On the cellular level, corticosteroids exert various effects that translate into the desired clinical activity, but they also evoke significant toxicity that may outweigh the beneficial effects. The mode of action and the limitations of steroid treatment are summarized in this review article. Interactions between steroids and other drugs must be considered. A particular challenge to the ongoing use of glucocorticoids is that newer therapeutic approaches are being introduced in neuro-oncology for which concomitant steroids are likely to be contraindicated. These include the emergence of various immunotherapeutic approaches including vaccination strategies and treatment with immune checkpoint inhibitors. Since the administration of steroids may interfere with the activity of these novel therapies, an even more critical evaluation of their use will be required.

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Evidence that cisplatin induces serotonin release from human peripheral blood mononuclear cells and that methylprednisolone inhibits this effect

Cited by 11 publications

References 11 publications

Antiemetic activity of corticosteroids in patients receiving cancer chemotherapy: dosing, efficacy, and tolerability analysis

Antiemetic activity of corticosteroids in patients receiving cancer chemotherapy: dosing, efficacy, and tolerability analysis

Preemptive Effects of Administration of Tualang Honey on Inflammatory Responses in Adult Male Rats

Corticosteroid use in neuro-oncology: an update

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