Evidence that dry eye is a comorbid pain condition in a U.S. veteran population

Lee, Charity J; Levitt, Roy C.; Felix, Elizabeth R.; Sarantopoulos, Constantine

doi:10.1097/pr9.0000000000000629

Cited by 20 publications

(23 citation statements)

References 53 publications

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“…Even though some cross-sectional/case-control studies based on patient clinics have shown positive association between DES and sleep disorders [ 15 , 16 , 17 ], there are few large-scale or nationwide studies. In particular, no findings associate DES with sleep disorders using national claim data in South Korea, because DES (International Classification of Diseases [ICD]-10 code: H04.11; new classification in 2011) was not identified in healthcare claim data before 2011.…”

Section: Introductionmentioning

confidence: 99%

Do Sleep Disorders Positively Correlate with Dry Eye Syndrome? Results of National Claim Data

Han

Nam

Park

2019

IJERPH

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Purpose: Dry eye syndrome (DES) is a common disease with an increasing occurrence. Although DES symptoms are considered mild, it can reduce quality of life for individuals. Many studies on DES have been conducted, but these focused on the use of electronic devices. Here, we investigate an association between DES and sleep disorders in the context of emerging health issues. Methods: Our data came from the National Health Insurance Service (NHIS) National Sample Cohort, which included 44,366 patients and was based on a 1:1 matching method (sleep disorder patients vs. patients without sleep disorders) during 2012–2015. Using survival analysis with a Cox proportional hazard model, we identified an association of sleep disorders with DES. Results: About 16.7% of all patients were diagnosed with DES, and prevalence was higher in patients with sleep disorders (sleep disorders: 19.82%, no sleep disorders: 13.67%). Survival analysis showed that sleep disorders positively correlated with DES diagnosis (Hazard Ratio (HR): 1.320, 95% Confidence Interval (CI): 1.261–1.382, p-value < 0.0001). Positive trends were enhanced in males, younger patients, lower economic levels, and with higher severity of comorbid. Conclusions: Our findings suggest that sleep disorder was positively associated with DES. This correlation can be helpful in effective management of both sleep disorders and DES in South Koreans.

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Section: Introductionmentioning

confidence: 99%

Do Sleep Disorders Positively Correlate with Dry Eye Syndrome? Results of National Claim Data

Han

Nam

Park

2019

IJERPH

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“…FM ve kuru göz ile ilgili yapılmış çok sayıda araştırma mevcuttur. Araştırmalar kuru gözün yaşlandıkça arttığını ve kadınlarda daha sık görüldüğünü ve kronik ağrı sendromlarıyla beraber sıklığının arttığını desteklemektedir (13). Yapılan çalışmada 50 yaşından sonra FM ile kuru göz birlikteliğinin arttığı, 65 yaşından sonra ise pik yaptığı gösterilmiştir (9).…”

Section: Discussionunclassified

Evaluation of Eye Findings in Fibromyalgia Patients

Karakoyun¹,

Yaşar²,

Gürlevik³

et al. 2019

Tod

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Objective: Fibromyalgia (FM) is a rheumatic disease which exactly unknown etiology, causes widespread body pain. In FM patients, a large variety of ocular findings, especially dry eye, occur with and without other rheumatic diseases. These ocular findings may be the first findings to warn the clinician for diagnosis in rheumatic diseases. The aim of this study is to evaluate the eye findings as clinically in patients with FM. Materials and Methods: The patients of those between the ages of 18-75, who were admitted to the Aksaray University Training and Research Hospital, Physical Medicine and Rehabilitation Polyclinic and diagnosed with FM, and then examined in the Ophthalmology Polyclinic, were included in the study. Patients' files were reviewed retrospectively. The clinical diagnosis, socio-demographic characteristics, ocular examination findings, history, family history and the results of the treatments were recorded. Those who had undergone eye surgery, rheumatologic disease, diabetic retinopathy, glaucoma, systemic infection, autoimmune disease, cerebrovascular disease, major depression, abnormal laboratory values, and history of malignancy, were not included in the study. The diagnosis of FM was determined according to the American College of Rheumatology updated in 2016. Results: The files of 94 patients who met the appropriate criteria were included in the study. The mean age of the patients was 38.2 (18-75), and 80 (85%) were female and 14 (15%) were male. According to the ocular findings, 57 patients (57.4%) had eye pain, 28.2% had redness, 26.9% had burning-stinging, 15.1% had turbidity, 6.3% had burring, and 3.7% had itching. Among the causes of eye pain were 49.1% dry eye, 24.6% refractive failure, 12.3% blepharitis, and 3.5% allergy, while no cause was found in 10.5%.

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“…We have termed this concept neuropathic ocular pain (NOP) to highlight the fact that pain generation can initiate from nerves on the ocular surface (cornea and conjunctiva) or from secondary and tertiary neurons that connect the ocular surface to the brain. Risk factors for the development of NOP include chronic overlapping pain conditions and migraine, and central sensitization is thought to link the entities 42, 43 .…”

Section: Aspects To Be Considered In Patients With Dry Eye Disease Symentioning

confidence: 99%

What’s new in dry eye disease diagnosis? Current advances and challenges

Aggarwal¹

2018

F1000Res

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Dry eye disease (DED) is a commonly encountered condition in general ophthalmology practice and imparts a significant socioeconomic burden. Despite its prevalence, there remain challenges regarding its diagnosis and management. A major reason behind these challenges is the fact that DED represents an umbrella term that encompasses many different underlying conditions and pathophysiological mechanisms. The purpose of this article is to highlight aspects of DED pathophysiology and focus on targeted diagnostic and therapeutic approaches to this multifactorial, chronic condition.

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Evidence that dry eye is a comorbid pain condition in a U.S. veteran population

Abstract: A retrospective review of 3,265,894 veterans seen over a 5-year period demonstrates dry eye is associated with numerous chronic pain conditions implying shared mechanisms.

Cited by 20 publications

References 53 publications

Do Sleep Disorders Positively Correlate with Dry Eye Syndrome? Results of National Claim Data

Do Sleep Disorders Positively Correlate with Dry Eye Syndrome? Results of National Claim Data

Evaluation of Eye Findings in Fibromyalgia Patients

What’s new in dry eye disease diagnosis? Current advances and challenges

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