Evidence that Extreme Dilutions of Paclitaxel and Docetaxel Alter Gene Expression of In Vitro Breast Cancer Cells

Şeker, Sinem; Güven, Cengiz; Akçakaya, Handan; Bahtiyar, Nurten; Akbaş, Fahri; Onaran, İlhan

doi:10.1055/s-0037-1618585

Cited by 10 publications

(10 citation statements)

References 28 publications

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“…In the recent past, many scientists have investigated homeopathic medicines, mostly as ultra-high dilutions potentized beyond Avogadro's limit, with the state-of-the-art tools of molecular biology (Şeker et al, 2018;Olsen, 2017;Bigagli et al, 2016;Chirumbolo and Bjørklund , 2016;Saha et al, 2015;Dei and Bernardini, 2015;Marzotto et al, 2014;Olioso et al, 2014;Das et al, 2012;Preethi et al, 2012;Sunila et al, 2009). Their work confirms the ability of homeopathic medicines to modulate gene expression in cell cultures.…”

Section: Evolution Of Homeopathic Phenomenon Through Hormesismentioning

confidence: 95%

Untitled

2020

WATER

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To understand evolution better, biologists should take into account the development of an organism's reaction to stressors (i.e.,the secondary action of a stressor) during development, and the subtle role it plays. Hormesis and homeopathic phenomena are just names to classify such secondry properties. These phenomena exploit the secondary action, below that of a pharmacological of toxin dose in a beneficial fashion. An intriguing examination of the biological behavior of the secondary action leads to the proposed theory. dilutions. Experimental support is emerging for this theory, and some suggestions have been given for testing and verification. As this theory concerns the evolution of the earliest medicine with an intrinsic role in the evolutionary process, it could influence the whole field of medical science.

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Section: Evolution Of Homeopathic Phenomenon Through Hormesismentioning

confidence: 95%

Untitled

2020

WATER

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“…13 Also, the taxane anti-cancer drugs paclitaxel and docetaxel, used in chemotherapy, diluted similarly showed differential effects on the genes of breast cancer cells without being cytotoxic. 14 Many different research groups have shown that various chemicals/drugs diluted homeopathically even beyond Avogadro's limit can stimulate hormetic responses in living cells. [15][16][17][18][19] Commenting on the work of Chikramane et al, 20 Calabrese suggested it as a step forward toward unification of hormesis and homeopathy.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring Possible Mechanisms of Hormesis and Homeopathy in the Light of Nanopharmacology and Ultra-High Dilutions

Ullman¹

2021

Dose-Response

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Serially diluted succussed solutions of a suitable drug/toxic substance can exhibit physicochemical and biological properties even far beyond Avogadro’s limit defying conventional wisdom. They can show hormesis, and homeopathy uses them as medicines. Many studies confirm that they can have an impact on gene expression different than controls. Water in the exclusion zone phase can have memory but for a short period. However, the nanoparticle as the physical substrate can hold information. Nanoparticle and exclusion zone duo as nanoparticle-exclusion zone shell can provide a prolonged memory. The Nanoparticle-Exclusion Zone Shell Model may be an important step toward explaining the nature and bioactivity of serially diluted succussed solutions used as homeopathic medicines. This model may also provide insight into the workings of hormesis. Hormesis is the primary phenomenon through which homeopathic phenomenon may have evolved exhibiting the principle of similars. Hahnemann exploited it to establish homeopathy. The nanoparticle-exclusion zone shells present in the remedy, selected on the principle of similars, can be patient-specific nanoparticles in a symptom syndrome-specific manner. They can carry the drug-specific information for safer clinical applications in an amplified form for high yielding. It suggests homeopathy is a type of nanopharmacology.

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“…A recent experimental in vitro study showed how important is it to characterize non-specific effects of vehicles. 59 From this perspective, using both succussed and non-succussed vehicles may represent a good standard for controls in future studies in Şeker et al 2018 32 Untreated cells (negative); undiluted alcohol (named placebo); tested drugs in pharmacological concentration (positive).…”

Section: Discussionmentioning

confidence: 99%

Homeopathy in Experimental Cancer Models: A Systematic Review

et al. 2020

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Background Complementary and alternative medicine, including homeopathy, is widely used to improve well-being among cancer patients and reduce adverse effects of conventional treatment. In contrast, there are few studies on the use of homeopathic medicines to treat the disease itself. Yet, evidence of possible effectiveness of homeopathic high dilutions in experimental cancer models has been published during the past 20 years. Aim The aim of the study was to perform a systematic review of fundamental research studies on homeopathic high dilutions in cancer. Methods Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, we conducted a literature search in the database PubMed for original publications, from 2000 to 2018 and in English, on in vitro and in vivo experimental cancer models testing homeopathic high dilutions. Results Twenty-three articles met the inclusion criteria—14 in vitro, eight in vivo, and one in vitro plus in vivo experimental models. Most studies were from India. Research prominently focused on cytotoxic effects involving apoptotic mechanisms. Intrinsic aspects of homeopathy should be considered in experimental designs to emphasize the specificity of such effects. Conclusion Fundamental research of homeopathy in cancer is still at an early stage and has mainly been performed by a few groups of investigators. The results point to an interference of well-selected homeopathic medicines with cell cycle and apoptotic mechanisms in cancer cells. However, these findings still need independent reproduction.

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Evidence that Extreme Dilutions of Paclitaxel and Docetaxel Alter Gene Expression of In Vitro Breast Cancer Cells

Abstract: Despite some limitations, our findings demonstrate that gene expression alterations also occur with ultra-high dilutions of taxane drugs.

Cited by 10 publications

References 28 publications

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Exploring Possible Mechanisms of Hormesis and Homeopathy in the Light of Nanopharmacology and Ultra-High Dilutions

Homeopathy in Experimental Cancer Models: A Systematic Review

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