Evidence that Genetic Variants of Metabolic Detoxication and Cell Cycle Control Are Not Related to Gallbladder Cancer Risk in Chilean Women

Abstract

These genetic variants were not related to an increased risk of GBC in Chilean women. Other polymorphisms, such as red-chili-pepper-related polymorphisms, may contribute to the development of GBC in Chilean women.

Cytochrome P450 in Cancer Susceptibility and Treatment

“…Another North Indian case-controlled study on 410 GBC cases and 230 healthy subjects found that CYP1A1 MspI (CC), CYP1A1 Ile462Val, and CYP1A1 haplotype (C-val) were significantly associated with GBC susceptibility [112]. However, three other studies did not find any association of CYP1A1 3801T/C polymorphism with GBC risk [113][114][115]. In a meta-analysis of three studies, no association between GBC risk and the CYP1A1 Ile462Val polymorphism was observed [116].…”

Candidate gene studies in gallbladder cancer: A systematic review and meta-analysis

“…Some studies/polymorphisms were not included in meta-analysis due to redundant information or missing data. All study populations were of mixed gender except in one study, Tsuchiya et al [48]. All studies were retrospective case-control studies.…”

“…Significant heterogeneity was observed ( Q =8.748, P =0.013, I 2 =77.14%, CC vs. SS; Table 4). Three studies comprising 154 cases and 348 controls evaluated a possible association between TP53 rs1042522 polymorphism and risk of GBC [48, 52-53]. No association was observed (OR=1.28, 95% CI=0.68-2.42, P =0.441; Table 4) and there was no heterogeneity ( Q =0.623, P =0.732, I 2 =0%).…”

“…The association of CYP1A1 rs1048943 polymorphism and GBC risk was evaluated in 4 studies that comprised 391 cases and 1085 controls [18, 48, 52-53]. No association between the risk for GBC and CYP1A1 rs1048943 polymorphism was observed (OR=0.72, 95% CI=0.42-1.22, P =0.221; Table 4).…”

“…There was no heterogeneity observed among the studies ( Q =4.311, P =0.116, I 2 =53.6%). Four studies examined the relationship between GSTM1 polymorphisms and risk of GBC in 260 cases and 549 controls [23, 48, 52-53]. Null allele of GSTM1 did not cause any increase in the risk for GBC (OR=1.08, 95% CI=0.73-1.60,; Table 4).…”