Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells with potential to inhibit SARS-CoV-2 infection and COVID-19 disease progression

Sheehan, Stephanie A.; Hamilton, Kelly L.; Retzbach, Edward P.; Balachandran, Premalatha; Krishnan, Harini; Leone, Paola; Lopez-Gonzalez, Moises; Suryavanshi, Shraddha; Kumar, Pradeep; Russo, Riccardo; Goldberg, Gary S.

doi:10.1016/j.yexcr.2021.112594

Cited by 16 publications

(15 citation statements)

References 64 publications

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“…MASL is an extremely abundant component in these extracts. MASL can survive digestion and has been found to inhibit viral infection, cancer, and inflammation, and arthritis progression [ 12 , 24 , [35] , [36] , [37] , [38] ].…”

Section: Discussionmentioning

confidence: 99%

Maackia amurensis seed lectin (MASL) ameliorates articular cartilage destruction and increases movement velocity of mice with TNFα induced rheumatoid arthritis

Hamilton¹,

Shienbaum²,

Fischer³

et al. 2022

Biochemistry and Biophysics Reports

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Section: Discussionmentioning

confidence: 99%

Maackia amurensis seed lectin (MASL) ameliorates articular cartilage destruction and increases movement velocity of mice with TNFα induced rheumatoid arthritis

Hamilton¹,

Shienbaum²,

Fischer³

et al. 2022

Biochemistry and Biophysics Reports

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“…Both plant lectins and griffithsin, the Man-specific lectin from the red alga Griffithsia sp., also inhibited the entry of SARS-CoV and MERS-CoV, respectively, in virus-infected cultured cells [42,74]. The Neu5Ac-specific Maackia amurensis lectin, MAL, inhibited the interaction of the SARS-CoV-2 S protein with the ACE2 receptor in cell cultures and decreased the expression of inflammatory mediators associated with COVID-19 disease progression [61].…”

Section: How Can the Infectivity Of Pathogenic Enveloped Viruses Be Affected By Lectins?mentioning

confidence: 96%

“…The effects of plant lectins on other pathogenic enveloped viruses have been more scarcely investigated. Plant lectins were identified as blocking agents for the entry of IV [45,52,57], HSV [57], HCMV [47,53,54], EBOV [47,48], LASV [47], and the coronaviruses MERS-CoV [51], SARS-CoV [42,51,54,62,63,104], and SARS-CoV-2 [50][51][52]58,60,61,66] in their corresponding host cells. However, depending on the viruses, the envelope glycoprotein(s) targeted by plant lectins are extremely diverse as mentioned in Table 2.…”

Section: How Can the Infectivity Of Pathogenic Enveloped Viruses Be Affected By Lectins?mentioning

confidence: 99%

Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses

Barre

Damme

Klonjkowski

et al. 2022

Cells

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Pathogenic enveloped viruses are covered with a glycan shield that provides a dual function: the glycan structures contribute to virus protection as well as host cell recognition. The three classical types of N-glycans, in particular complex glycans, high-mannose glycans, and hybrid glycans, together with some O-glycans, participate in the glycan shield of the Ebola virus, influenza virus, human cytomegalovirus, herpes virus, human immunodeficiency virus, Lassa virus, and MERS-CoV, SARS-CoV, and SARS-CoV-2, which are responsible for respiratory syndromes. The glycans are linked to glycoproteins that occur as metastable prefusion glycoproteins on the surface of infectious virions such as gp120 of HIV, hemagglutinin of influenza, or spike proteins of beta-coronaviruses. Plant lectins with different carbohydrate-binding specificities and, especially, mannose-specific lectins from the Vicieae tribe, such as pea lectin and lentil lectin, can be used as glycan probes for targeting the glycan shield because of their specific interaction with the α1,6-fucosylated core Man3GlcNAc2, which predominantly occurs in complex and hybrid glycans. Other plant lectins with Neu5Ac specificity or GalNAc/T/Tn specificity can also serve as potential glycan probes for the often sialylated complex glycans and truncated O-glycans, respectively, which are abundantly distributed in the glycan shield of enveloped viruses. The biomedical and therapeutical potential of plant lectins as antiviral drugs is discussed.

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“…Moreover, a previous study showed that SARS-CoV-2 could infect epithelial cells in situ and then shed into saliva which confirmed by scRNA-seq, orthogonal RNA, and protein expression analysis ( 83 ). Furthermore, it was demonstrated the inhibited expression of ACE2 and Furin through Maackia amurensis seed lectin (MASL) which has a potential therapeutic effect on COVID-19 by decreasing the expression of inflammatory mediators by oral epithelial cells ( 84 ). Considering of host response in SARS-CoV-2 infection, scRNA-seq and transcriptomic analysis were performed.…”

Section: Multi-omics Analysis Of Covid-19mentioning

confidence: 99%

Pathogenic Mechanism and Multi-omics Analysis of Oral Manifestations in COVID-19

et al. 2022

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Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease that seriously threatens human life. The clinical manifestations of severe COVID-19 include acute respiratory distress syndrome and multiple organ failure. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID-19, spreads through contaminated droplets. SARS-CoV-2 particles have been detected in the saliva of COVID-19 patients, implying that the virus can infect and damage the oral cavity. The oral manifestations of COVID-19 include xerostomia and gustatory dysfunction. Numerous studies showed that the four structural proteins of SARS-CoV-2 are its potential pathogenic factors, especially the S protein, which binds to human ACE2 receptors facilitating the entry of the virus into the host cells. Usually, upon entry into the host cell, a pathogen triggers the host’s immune response. However, a mount of multi-omics and immunological analyses revealed that COVID-19 is caused by immune dysregulation. A decrease in the number and phenotypes of immune cells, IFN-1 production and excessive release of certain cytokines have also been reported. In conclusion, this review summarizes the oral manifestations of COVID-19 and multi-omics analysis of SARS-CoV-2 infection.

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Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells with potential to inhibit SARS-CoV-2 infection and COVID-19 disease progression

Cited by 16 publications

References 64 publications

Maackia amurensis seed lectin (MASL) ameliorates articular cartilage destruction and increases movement velocity of mice with TNFα induced rheumatoid arthritis

Maackia amurensis seed lectin (MASL) ameliorates articular cartilage destruction and increases movement velocity of mice with TNFα induced rheumatoid arthritis

Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses

Pathogenic Mechanism and Multi-omics Analysis of Oral Manifestations in COVID-19

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