1994
DOI: 10.1111/j.1476-5381.1994.tb14822.x
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Evidence that nitric oxide is an endogenous antiangiogenic mediator

Abstract: The involvement of nitric oxide (NO) in the regulation of angiogenesis was examined in the in vivo system of the chorioallantoic membrane (CAM) of the chick embryo and in the matrigel tube formation assay. Sodium nitroprusside (SNP) (0.37–28 nmol/disc), which releases NO spontaneously, caused a dose‐dependent inhibition of angiogenesis in the CAM in vivo and reversed completely the angiogenic effects of α‐thrombin (6.7 nmol/disc) and the protein kinase C (PKC) activator 4‐β‐phorbol‐12‐myristate‐13‐acetate (PMA… Show more

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Cited by 155 publications
(88 citation statements)
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“…The NO is one of the most important mediator of angiogenesis. However, in the literature there exists controversial data supporting its pro-angiogenic [41] and its anti-angiogenic effects as well [42]. Our results showing reduced endothelial NOS activity and subcellular markers of angiogenesis in both experimental groups support anti-angiogenic effect of NO.…”
Section: Discussionsupporting
confidence: 69%
“…The NO is one of the most important mediator of angiogenesis. However, in the literature there exists controversial data supporting its pro-angiogenic [41] and its anti-angiogenic effects as well [42]. Our results showing reduced endothelial NOS activity and subcellular markers of angiogenesis in both experimental groups support anti-angiogenic effect of NO.…”
Section: Discussionsupporting
confidence: 69%
“…NO can interact with a variety of biomolecules. Of them, soluble guanylate cyclase is activated by interaction of its cofactor heme with NO and increases the intracellular level of cGMP, acting as intracellular signal mediator for vasodilation, anti-apoptosis, and angiogenesis (Forstermann et al, 1986;Pipili-Synetos et al, 1994;Kim YM et al, 1997). In the present study, we showed that the soluble guanylate cyclase inhibitor ODQ inhibited the angiogenic activity of PGE2 in cultured HUVECs and murine aortic ring segments, whereas PGE2 could not stimulate endothelial sprouts in aortic ring segments from eNOS-deficient mice.…”
Section: Discussionmentioning
confidence: 43%
“…A role for NO in angiogenesis has previously been implicated. The evidence indicates that NO is an important regulator of angiogenesis under basal conditions and an inhibitor of agents which promote the angiogenic response [32,33]. On the basis of our observations we suggest that iNOS at the centre of the ulcer is acting to remove microbial contamination as a means to debride the wound.…”
Section: Discussionmentioning
confidence: 56%