Evidence that oxytocin is a physiological component of LH regulation in non-pregnant women

Evans, JJ; Reid, Robert A.; Wakeman, Sarah; Croft, Lori B.; Benny, P. S.

doi:10.1093/humrep/deg291

Cited by 35 publications

(30 citation statements)

References 32 publications

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“…It has been shown that oxytocin promotes the LH surge during the follicular phase [21], and that the maximum LH levels are reduced after administration of the oxytocin antagonist atosiban in healthy volunteers [22]. Atosiban has also been shown to inhibit FSH release, but with a less significant effect than that seen for LH [22]. In the present study we found higher concentrations of FSH during the menstrual and early follicular phases as well as a higher concentration of 17b-E 2 during the late follicular phase in dysmenorrheic patients.…”

Section: Discussionmentioning

confidence: 99%

Reproductive hormones in plasma over the menstrual cycle in primary dysmenorrhea compared with healthy subjects

Liedman

Hansson

Howe

et al. 2008

Gynecological Endocrinology

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The pathogenesis of primary dysmenorrhea is still poorly understood. The objective of the present investigation was to study differences in plasma concentrations of reproductive hormones in women with primary dysmenorrhea vs. healthy controls. In a prospective, parallel-group study we determined the plasma concentrations of oxytocin, vasopressin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17beta-estradiol (17beta-E2), progesterone and prostaglandin F 2alpha metabolite (15-keto-13,14-dihydro-PGF 2alpha) over one menstrual cycle in eight women with primary dysmenorrhea and eight healthy volunteers. In dysmenorrheic women the plasma concentration of oxytocin was significantly higher at menstruation (p = 0.0084) and that of vasopressin significantly lower at ovulation (p = 0.0281) compared with healthy women. They had also higher FSH levels in the early follicular phase (p = 0.0087) and at menstruation (p = 0.0066) and the 17beta-E2 concentration was higher in the late follicular phase (p = 0.0449). No differences were seen for LH, progesterone and PGF 2alpha metabolite. The differences of oxytocin, vasopressin, FSH and 17beta-E2 concentrations found in plasma suggest an involvement of these hormones in mechanisms of primary dysmenorrhea. These mechanisms seem to be mainly regulated through the hypothalamus and pituitary. The influence of oxytocin on the non-pregnant uterus seems to be more important than earlier believed.

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Section: Discussionmentioning

confidence: 99%

Reproductive hormones in plasma over the menstrual cycle in primary dysmenorrhea compared with healthy subjects

Liedman

Hansson

Howe

et al. 2008

Gynecological Endocrinology

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“…Thus, OXT can modulate ACTH and cortisol secretion to mobilize body function but curbs its potentially harmful consequence. In addition, OXT is also found to increase the release of prolactin [58, 59], α -MSH [60], LH [61], and FSH [62] as well as its own release [4, 63]. On the contrary, OXT inhibits TSH [64] and GH [65] release.…”

Section: Effects On Endocrine Systemsmentioning

confidence: 99%

“…Thus, plasma OXT fluctuates throughout the menstrual cycle in normally cycling healthy fertile women. OXT can advance the LH surge; conversely, OXTR antagonists inhibit full production of the LH surge [61]. Thus, the high level of OXT before luteal phase has a role in the physiological processes of LH regulation; therefore OXT can modulate ovulation and the ensuing pregnancy.…”

Section: Reproductive Functionsmentioning

confidence: 99%

Nonsocial Functions of Hypothalamic Oxytocin

et al. 2013

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Oxytocin (OXT) is a hypothalamic neuropeptide composed of nine amino acids. The functions of OXT cover a variety of social and nonsocial activity/behaviors. Therapeutic effects of OXT on aberrant social behaviors are attracting more attention, such as social memory, attachment, sexual behavior, maternal behavior, aggression, pair bonding, and trust. The nonsocial behaviors/functions of brain OXT have also received renewed attention, which covers brain development, reproduction, sex, endocrine, immune regulation, learning and memory, pain perception, energy balance, and almost all the functions of peripheral organ systems. Coordinating with brain OXT, locally produced OXT also involves the central and peripheral actions of OXT. Disorders in OXT secretion and functions can cause a series of aberrant social behaviors, such as depression, autism, and schizophrenia as well as disturbance of nonsocial behaviors/functions, such as anorexia, obesity, lactation failure, osteoporosis, diabetes, and carcinogenesis. As more and more OXT functions are identified, it is essential to provide a general view of OXT functions in order to explore the therapeutic potentials of OXT. In this review, we will focus on roles of hypothalamic OXT on central and peripheral nonsocial functions.

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“…HIV, seizures, cardiovascular, kidney or endocrine diseases, diabetes, high blood pressure, and history of head trauma or loss of consciousness > 20 minutes) and current use of prescription medication. Female participants were excluded for the following reasons: (i) the male to female ratio for ASPD is 9 to 1, respectively (APA, 2000), thus female participants would be not representative of the target populations desired in this study, (ii) the neuropeptide oxytocin increases levels of luteinizing hormone (Evans, Reid, Wakeman, Croft, & Benny, 2003) which could potentially affect the regularly occurring menstrual cycles of female participants, and (iii) to our knowledge there are no reports of the interactions of oxytocin administration with oral contraceptives (i.e. birth control), thus behavioral and physiological side effects are unknown.…”

Section: Methodsmentioning

confidence: 99%

Effects of Intranasal Oxytocin on Aggressive Responding in Antisocial Personality Disorder

et al. 2015

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The oxytocin receptor is important in several domains of social behavior, and administration of oxytocin modulates social responding in several mammalian species, including humans. Oxytocin has both therapeutic and scientific potential for elucidating the neural and behavioral mechanisms governing social behavior. In the present study, operationally-defined aggressive behavior of six males with Antisocial Personality Disorder (ASPD) was measured following acute intranasal oxytocin dosing (12, 24, and 48 international units) and placebo, using a well-validated laboratory task of human aggression (Point-Subtraction Aggression Paradigm, or PSAP). The PSAP provides participants with concurrently available monetary-earning and operationally-defined aggressive response options, maintained by fixed ratio schedules of consequences. Shifts in response rates and inter-response time (IRT) distributions were observed on the aggressive response option following oxytocin doses, relative to placebo. Few changes were observed in monetary-reinforced responding. However, across participants the direction and magnitude of changes in aggressive responding were not systematically related to dose. No trends were observed between psychometric or physiological data and oxytocin dosing or aggressive behavior. While this report is to our knowledge the first to examine the acute effects of oxytocin in this population at high risk for violence and other forms of antisocial behavior, several limitations in the experimental design and the results cast the study as a preliminary report. Strategies for more extensive future projects are discussed.

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Evidence that oxytocin is a physiological component of LH regulation in non-pregnant women

Abstract: The results indicated that inhibition of endogenous oxytocin affects the endocrinology of the ovulatory cycle in women, and strongly suggest that oxytocin has a role in the physiological processes of LH regulation.

Cited by 35 publications

References 32 publications

Reproductive hormones in plasma over the menstrual cycle in primary dysmenorrhea compared with healthy subjects

Reproductive hormones in plasma over the menstrual cycle in primary dysmenorrhea compared with healthy subjects

Nonsocial Functions of Hypothalamic Oxytocin

Effects of Intranasal Oxytocin on Aggressive Responding in Antisocial Personality Disorder

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