2020
DOI: 10.1101/2020.05.14.096255
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Evidence that polyploidy in esophageal adenocarcinoma originates from mitotic slippage caused by defective chromosome attachments

Abstract: Polyploidy is present in many cancer types and is increasingly recognized as an important factor in promoting chromosomal instability, genome evolution, and heterogeneity in cancer cells. However, the mechanisms that trigger polyploidy in cancer cells are largely unknown. In this study, we investigated the origin of polyploidy in esophageal adenocarcinoma (EAC), a highly heterogenous cancer, using a combination of genomics and cell biology approaches in EAC cell lines, organoids, and tumors. We found the EAC c… Show more

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(2 citation statements)
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“…Dysfunction at this stage of mitosis is associated with aneuploidy and polyploidy. BE and EAC cells demonstrate abnormal expression of kinetochore constituents in association with chromosome congression failure 15 …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Dysfunction at this stage of mitosis is associated with aneuploidy and polyploidy. BE and EAC cells demonstrate abnormal expression of kinetochore constituents in association with chromosome congression failure 15 …”
Section: Discussionmentioning
confidence: 99%
“…The Kinetochore Metaphase Signaling Pathway contains genes encoding proteins responsible for the adequate function of the kinetochore complex, via which chromosomes attach to spindle microtubules during metaphase. 15 Dysfunction at this stage of mitosis is associated with aneuploidy and polyploidy. BE and EAC cells demonstrate abnormal expression of kinetochore constituents in association with chromosome congression failure.…”
Section: Pathways Analysesmentioning
confidence: 99%