EVIDENCE THAT THE HYPOTHALAMUS IS RESPONSIBLE FOR ANDROGEN-INDUCED STERILITY IN THE FEMALE RAT<sup>1</sup>

Barraclough, Charles A.; Gorski, Roger A.

doi:10.1210/endo-68-1-68

Cited by 422 publications

(139 citation statements)

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“…It had been demonstrated that perinatal administration of sex steroids induces persistent vaginal estrus associated with the lack of estrous cyclicity in rats (Barraclough and Gorski, 1961). This was also demonstrated in the --659 present study.…”

Section: Effects Of Perinatal Exposure On Female Reproductive Functionsupporting

confidence: 84%

Effects of Phthalate/Adipate Esters Exposure during Perinatal Period on Reproductive Function after Maturation in Rats

Yamanouchi

Nishihara

2006

Journal of Animal Science and Technology

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Section: Effects Of Perinatal Exposure On Female Reproductive Functionsupporting

confidence: 84%

Effects of Phthalate/Adipate Esters Exposure during Perinatal Period on Reproductive Function after Maturation in Rats

Yamanouchi

Nishihara

2006

Journal of Animal Science and Technology

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“…Females from different litters were injected with 0.02 ml of sesame oil alone (n ¼ 14). This treatment has been used frequently to study the organizational effects of androgens on the brain and has been shown effective for masculinizing the female brain and many aspects of behavior (Barraclough and Gorski, 1961;Beatty and Beatty, 1970;Shors and Miesegeas, 2002).…”

Section: General Proceduresmentioning

confidence: 99%

“…Many sex differences in adult behaviors can be reversed or at least minimized by manipulation of sex steroids during development (Barraclough and Gorski, 1961;Beatty and Beatty, 1970;Shors and Miesegeas, 2002;Williams et al, 1990). Testosterone treatment of females at birth alters the phenotype of the hypothalamic-pituitary-adrenal axis (Seale et al, 2005), the morphology of sexually dimorphic brain regions (Han and De Vries, 2003;MacLusky et al, 1987;Morris et al, 2004;Roselli and Klosterman, 1998) and affects certain aspects of learning (Roof, 1993;Roof and Havens, 1992;Shors and Miesegeas, 2002;Williams and Meck, 1991).…”

Section: Sex Differences In Helplessnessmentioning

confidence: 99%

Females do not Express Learned Helplessness like Males do

Dalla

Edgecomb

Whetstone

et al. 2007

Neuropsychopharmacol

151

101

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Women are more likely than men to suffer from stress-related mental disorders, such as depression. In the present experiments, we identified sex differences in one of the most common animal models of depression, that of learned helplessness. Male and female rats were trained to escape a mild footshock each day for 7 days (controllable stress). Each rat was yoked to another rat that could not escape (uncontrollable stress), but was exposed to the same amount of shock. One day later, all stressed rats and unstressed controls were tested on a more difficult escape task in a different context. Most males exposed to uncontrollable stress did not learn to escape and were therefore helpless. In contrast, most females did learn to escape on the more difficult escape task, irrespective of whether they had been exposed to controllable or uncontrollable stress. The sex differences in helplessness behavior were not dependent on the presence of sex hormones in adulthood, because neither ovariectomy of females nor castration of males abolished them. The absence of helplessness in females was neither dependent on organizational effects of testosterone during the day of birth, because masculinized females did not express helplessness as adults. Thus, sex differences in helplessness behavior are independent of gonadal hormones in adulthood and testosterone exposure during perinatal development. Learned helplessness may not constitute a valid model for depressive behavior in women, at least as reflected by the response of female rats to operant conditioning procedures after stressful experience.

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“…The mechanisms of inducing hyperprolactinemia in rats by androgen or hCG appear different. In the case of androgen, androgen appears to disturb the cyclic center located in the suprachiasmatic area of the hypothalamus (Barraclough and Gorski 1961), resulting in an acyclicity and hyperprolactinemia.…”

Section: Discussionmentioning

confidence: 99%

Formation of polycystic ovary in mature rats by the long-term administration of human chorionic gonadotropin.

Ota

Fukushima

Maki

1987

Tohoku J. Exp. Med.

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EVIDENCE THAT THE HYPOTHALAMUS IS RESPONSIBLE FOR ANDROGEN-INDUCED STERILITY IN THE FEMALE RAT¹

Cited by 422 publications

References 0 publications

Effects of Phthalate/Adipate Esters Exposure during Perinatal Period on Reproductive Function after Maturation in Rats

Effects of Phthalate/Adipate Esters Exposure during Perinatal Period on Reproductive Function after Maturation in Rats

Females do not Express Learned Helplessness like Males do

Formation of polycystic ovary in mature rats by the long-term administration of human chorionic gonadotropin.

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EVIDENCE THAT THE HYPOTHALAMUS IS RESPONSIBLE FOR ANDROGEN-INDUCED STERILITY IN THE FEMALE RAT1

Cited by 422 publications

References 0 publications

Effects of Phthalate/Adipate Esters Exposure during Perinatal Period on Reproductive Function after Maturation in Rats

Effects of Phthalate/Adipate Esters Exposure during Perinatal Period on Reproductive Function after Maturation in Rats

Females do not Express Learned Helplessness like Males do

Formation of polycystic ovary in mature rats by the long-term administration of human chorionic gonadotropin.

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EVIDENCE THAT THE HYPOTHALAMUS IS RESPONSIBLE FOR ANDROGEN-INDUCED STERILITY IN THE FEMALE RAT¹