Evidenced-Based and Practical Management of Real-World Valvular Heart Disease

Carabello, Blasé A.

doi:10.1007/978-1-4471-2840-3_13

Cited by 1 publication

(1 citation statement)

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“…However, it is commonly accepted that the genetic abnormalities are responsible for the defective synthesis of elastic fibres and collagen, respectively, which directly weakens the valve structure or indirectly alters the muscular contraction, placing greater stress on the valves and inducing the myxomatous alterations. 32 The myxomatous valve can be distinguished from rheumatic valvular disease by retraction and fusion of the chordae, as well as commissural fusion and the presence of inflammatory infiltration and neoformed vessels in the latter. 33 The prevalence of at least mild MVP in MFS has been estimated to be approximately 75%, whereas the prevalence of more severe myxomatous MV thickening with prolapse is closer to 25% in these individuals.…”

Section: Discussionmentioning

confidence: 99%

Chest pain and palpitations in postmenopausal women with mitral valve prolapse: is there a gastro‐oesophageal origin?

Maiello

Zito

Cecere

et al. 2022

Internal Medicine Journal

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Background and aim Mitral valve prolapse (MVP) is a common disease in women, causing chest pain and palpitation due to structural and functional valve abnormality, and is sometimes associated with gastro‐oesophageal reflux disease (GERD). This is a challenging clinical problem in clinical practice and requires targeted diagnostic assessment to identify the underlying causes of the symptoms, because treatment needs to be tailored, according to the causes themselves, to resolve the symptoms. Aim To assess the prevalence of GERD in a population of postmenopausal women affected by MVP and determine if there is any correlation between the two conditions. Methods The MVP diagnosis was performed using echocardiograpy examination, according to American Society Echocardiography criteria. Two hundred and eighty‐nine consecutive MVP women, symptomatic for chest pain and palpitation, were included; 250 consecutive women without MVP, symptomatic for chest pain and palpitation, were the control group (CG). The GERD diagnosis was made according to 2013 American College Gastroenterology criteria; women affected by thyroid disorders, all heart disease, including mitral disease with moderate or severe mitral regurgitation, and gastrointestinal diseases assessed using gastroscopy were excluded. Results Among 289 women with MVP, 31 (11%) women were affected by GERD, and among 250 in the CG, 11 (4.4%) women were affected by GERD: Chi‐squared 8.1; odds ratio 2.7; P < 0.0044. Twenty‐six (9%) women affected by GERD, with MVP, presented with mild mitral regurgitation, and 7 (2.8%) women in the CG presented with mild mitral regurgitation as well: Chi‐squared 8.95; odds ratio 3.4; 95% CI, P < 0.0028. Discussion and conclusions GERD is relatively common in women with MVP. Moreover, women with MVP are approximately three times more likely to be affected by GERD; the two conditions are correlated in a statistically high significant way. GERD assessment needs to be included into routine follow‐up strategies in women with MVP to optimise medical therapy, improvinge symptom relief for better quality of life.

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Section: Discussionmentioning

confidence: 99%