Evidences of antihypertensive potential of extract from Solanum capsicoides All. in spontaneously hypertensive rats

Simões, Letícia Oliveira; Conceição-Filho, G.; Ribeiro, Tatiana Silva; Jesus, A.M.; Fregoneze, J.B.; Silva, A.Q.G.; Petreanu, Marcel; Cechinel‐Filho, Valdir; Niero, Rivaldo; Niero, H.; Tamanaha, M.S.; Silva, D.F.

doi:10.1016/j.phymed.2016.02.020

Cited by 9 publications

(4 citation statements)

References 26 publications

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“…The genus is well represented in Brazil with about 350 species widely distributed from north to south in diverse phytogeographic regions [70, 80]. In Brazil (Ceará, Bahia, Mato Grosso do Sul, Paraná and north-central coast of Santa Catarina State), many Solanum species, usually known as ‘yubeba’, the word that refers to the prickles found on the stems of several of the species, are widely used in traditional medicine [66, 80, 87]. In the northeast of Brazil, 80 Solanum species are distributed throughout the region and used in folk medicine.…”

Section: Introductionmentioning

confidence: 99%

“…In the northeast of Brazil, 80 Solanum species are distributed throughout the region and used in folk medicine. One of such species is S. capsicoides , commonly known as “Gogoia” [87]. In East Africa, several Solanum species such as S. arundo and S. incanum are known to be poisonous and are reportedly used to induce miscarriages [64].…”

Section: Introductionmentioning

confidence: 99%

“…The genus Solanum is considered to be one of the largest and most complex genera among the Angiosperms [1], and the most representative and largest genus of the family Solanaceae [1–4]. It is comprised of about 2000 species distributed across subtropical and tropical regions of Asia [3–9], tropical Africa [10–29], non-arid Africa [30–43], Americas [44–87], Australia [71–74, 81–84] and India [71]. The genus is well represented in Brazil with about 350 species widely distributed from north to south in diverse phytogeographic regions [70, 80].…”

Section: Introductionmentioning

confidence: 99%

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The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

111

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Over the past 30 years, the genus Solanum has received considerable attention in chemical and biological studies. Solanum is the largest genus in the family Solanaceae, comprising of about 2000 species distributed in the subtropical and tropical regions of Africa, Australia, and parts of Asia, e.g., China, India and Japan. Many of them are economically significant species. Previous phytochemical investigations on Solanum species led to the identification of steroidal saponins, steroidal alkaloids, terpenes, flavonoids, lignans, sterols, phenolic comopunds, coumarins, amongst other compounds. Many species belonging to this genus present huge range of pharmacological activities such as cytotoxicity to different tumors as breast cancer (4T1 and EMT), colorectal cancer (HCT116, HT29, and SW480), and prostate cancer (DU145) cell lines. The biological activities have been attributed to a number of steroidal saponins, steroidal alkaloids and phenols. This review features 65 phytochemically studied species of Solanum between 1990 and 2018, fetched from SciFinder, Pubmed, ScienceDirect, Wikipedia and Baidu, using “Solanum” and the species’ names as search terms (“all fields”).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

111

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“…The extraction of leaf compounds characterizes the red soda apple as a phytotherapeutic plant with an antihypertensive effect, reducing cardiac hypertrophy and improving vascular function (Simões et al 2016). It also contains antidepressant compounds such as cilistol A, astragalin, and cilistadiol, and the absence of toxicity, allowing the replacement of old compounds used in the production of antidepressant drugs with side effects that lead to treatment discontinuation (Petreanu et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Luminosity, temperature, and substrates on the germination of Solanum capsicoides

Baptista

Alexandre²,

Lima³

et al. 2022

Biosci. J.

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Solanum capsicoides, commonly known as red soda apple, is a little-studied species with phytotherapeutic characteristics of interest to the pharmaceutical industry. However, little is known about its agronomic characteristics. Therefore, this study aimed to assess the effect of light, different temperatures, and substrates on the germination of S. capsicoides seeds. The study consisted of two experiments: Experiment I - Germination of S. capsicoides seeds under different wavelengths. The seeds were kept on Petri dishes covered with Germitest™ paper moistened with distilled water and exposed to the monochromatic, red, far-red, and dark wavelengths. The experiment was performed in a completely randomized design with four replications of 25 seeds. Experiment II - Germination of S. capsicoides seeds on different substrates and at different temperatures. The seeds were distributed according to six substrates: paper roll, on paper, between sand, on sand, on soil + sand + manure, and between soil + sand + manure. The seeds were also subjected to the constant temperatures of 20, 25, 30, and 35 °C and the alternate temperatures of 20-30, 20-35, 25-30, and 25-35 °C, characterizing a 6 x 8 factorial arrangement. Germination rate, germination speed index, and mean germination time were evaluated. Red soda apple seeds are classified as positive photoblastic, with the highest germination rate occurring at the temperature of 20-35 °C combined with on paper, paper roll, on sand, and between sand substrates.

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Antiproliferative and toxicological properties of methanolic extract obtained from Solanum capsicoides All. seeds and carpesterol

Petreanu

Guimarães

Broering

et al. 2016

Naunyn-Schmiedeberg's Arch Pharmacol

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Natural products are considered important sources of potential chemotherapeutic agents. Here, we evaluated the antiproliferative activity and the toxicological effects of the methanolic extract and a pure compound obtained from Solanum capsicoides seeds. The phytochemical profile was analyzed by chromatographic and spectroscopy methods. The acute toxicity was assessed in mice orally treated with the extract (2000 mg/kg), in vitro hemolytic activity and micronucleus test. The mutagenicity, developmental toxicity, and lethal dose (LD50) of carpesterol were estimated by the Toxicity Estimation Software Tool (TEST) software. A sulforhodamine B assay was employed to evaluate the antiproliferative activity. The toxicological assays did not observe signs of toxicity, either during the behavioral observations or in the autopsies, as well as no mutagenicity and hemolytic activity. The carpesterol did not present mutagenic effect and hemolytic activity but presents developmental toxicology and LD50 of 410 mg/kg in toxicity estimations by the TEST software. The S. capsicoides extract exhibited antiproliferative activity mainly in leukemia (K562) cell lineage. However, carpesterol presented antiproliferative activity in glioma (U251), breast (MCF-7), kidney (786-0), ovary (OVCAR-03), and K562 cell lineages. The data obtained show that S. capsicoides extract presents antiproliferative and does not present toxicological effects. In addition, it was shown for the first time the antiproliferative and toxicological parameters of carpesterol.

show abstract

Evidences of antihypertensive potential of extract from Solanum capsicoides All. in spontaneously hypertensive rats

Cited by 9 publications

References 26 publications

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Luminosity, temperature, and substrates on the germination of Solanum capsicoides

Antiproliferative and toxicological properties of methanolic extract obtained from Solanum capsicoides All. seeds and carpesterol

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