Evidences of Vascular Occlusion in Multiple Sclerosis and "Encephalomyelitis"

Influence of Human Allergic Encephalitogenic Peptide on Platelet Aggregation in Multiple Sclerosis

“…Our results suggest an explanation for the well known fact that thromboses and platelet aggregates occur in the veins situated at the center of MS plaques [4], Further studies with a larger number of MS patients (and a control group of patients with other neuro logical diseases) and with myelin basic pro tein as antigen are needed to determine the specificity and the possible pathogenetical relevance of these findings.…”

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“…Lhermitte (1950) and Lumsden (1975) The striking proclivity to thromboses affecting veins downstream of recent plaques (Rossolimo 1904, Putnam 1937, Dow, Berglund 1942, Prineas 1975) possibly relates to vein wall damages due to reflux. Leaky brain veins (Broman 1964) may also form the point of exit for the observed derangements in the system of coagulation (Prineas 1975, Brunetti et al 1981, Prosiegel et al 1982.…”

On a possible endogenous traumatization of brain, spinal cord, and nerve roots

“…Lhermitte (1950) and Lumsden (1975) The striking proclivity to thromboses affecting veins downstream of recent plaques (Rossolimo 1904, Putnam 1937, Dow, Berglund 1942, Prineas 1975) possibly relates to vein wall damages due to reflux. Leaky brain veins (Broman 1964) may also form the point of exit for the observed derangements in the system of coagulation (Prineas 1975, Brunetti et al 1981, Prosiegel et al 1982.…”