Evidences that maternal swimming exercise improves antioxidant defenses and induces mitochondrial biogenesis in the brain of young Wistar rats

Marcelino, Thiago Beltram; Longoni, Aline; Kudo, Karen Yurika; Stone, Vinícius; Rech, Anderson; Assis, Adriano Martimbianco de; Scherer, Emilene B. S.; Cunha, Maira J. da; Wyse, Ângela T. S.; Pettenuzzo, Letícia Ferreira; Leipnitz, Guilhian; Matté, Cristiane

doi:10.1016/j.neuroscience.2013.04.043

Cited by 64 publications

(61 citation statements)

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“…53 The cognitive and emotional improvements may be due to maternal exercise-induced increase in neural Bdnf (a neurotrophic factor associated with enhanced learning and memory abilities), especially in the hippocampus and prefrontal cortex, [51][52][53] , leptin (Lep, a satiety hormone), 49 Vegf (an angiogenic protein) in the prefrontal cortex, 53 and c-Fos (a proto-oncogene) expression in the perirhinal cortex. 50 Further, maternal exercise may exert positive effects on brain mitochondrial function 51,54 and neuron cell numbers and viability. 49,52,55 Dendritic growth of parietal neurons is blunted in offspring of dams subjected to prenatal restraint stress.…”

Section: Maternal Exercise and Offspring Behavioral And Reproductive mentioning

confidence: 99%

“…However, maternal exercise before or during gestation alleviated these metabolic disruptions in male offspring Maternal exercise during pregnancy When tested in a Morris Water Maze that measures spatial learning and memory, offspring from exercised dams learned the platform earlier and spent more time in the correct quadrant. This group also demonstrated decreased thigmotaxis behavior, suggestive of reduced anxiety Increased neurons were evident in the CA1 and C3 regions of the hippocampus and gyrus dentatus region in offspring from exercised dams Lepr was increased in prepubertal and adult male and adult female offspring from exercised dams 50 Male Long Evans rats Maternal exercise during pregnancy Male offspring of exercised dams were able to discriminate between novel and familiar objects, but those from non-exercise dams were not able to do so Increased expression of C-fos (a proto-oncogene) was evident in the perirhinal cortex of male offspring of exercised dams 54 Male and female Wistar rats Female Wistar rats were subjected to five swimming lesson before mating and then trained during pregnancy…”

Section: Maternal Exercise and Offspring Behavioral And Reproductive mentioning

confidence: 99%

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Homage to the ‘H’ in developmental origins of health and disease

Rosenfeld

2016

J Dev Orig Health Dis

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Abundant evidence exists linking maternal and paternal environments from pericopconception through the postnatal period to later risk to offspring diseases. This concept was first articulated by the late Sir David Barker and as such coined the Barker Hypothesis. The term was then mutated to Fetal Origins of Adult Disease and finally broadened to developmental origins of adult health and disease (DOHaD) in recognition that the perinatal environment can shape both health and disease in resulting offspring. Developmental exposure to various factors, including stress, obesity, caloric-rich diets and environmental chemicals can lead to detrimental offspring health outcomes. However, less attention has been paid to date on measures that parents can take to promote the long-term health of their offspring. In essence, have we neglected to consider the ‘H’ in DOHaD? It is the ‘H’ component that should be of primary concern to expecting mothers and fathers and those seeking to have children. While it may not be possible to eliminate exposure to all pernicious factors, prevention/remediation strategies may tip the scale to health rather than disease. By understanding disruptive DOHaD mechanisms, it may also illuminate behavioral modifications that parents can adapt before fertilization and throughout the neonatal period to promote the lifelong health of their male and female offspring. Three possibilities will be explored in the current review: parental exercise, probiotic supplementation and breastfeeding in the case of mothers. The ‘H’ paradigm should be the focus going forward as a healthy start can indeed last a lifetime.

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Section: Maternal Exercise and Offspring Behavioral And Reproductive mentioning

confidence: 99%

Section: Maternal Exercise and Offspring Behavioral And Reproductive mentioning

confidence: 99%

Homage to the ‘H’ in developmental origins of health and disease

Rosenfeld

2016

J Dev Orig Health Dis

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“…Given the intrinsic relationship between energy production and mitochondria, it is not surprising that mitochondrial energy metabolism plays a pivotal role in how maternal exercise affects the synaptic plasticity and cognition of offspring [38,39].…”

Section: Neurobiological Mechanismsmentioning

confidence: 99%

Physical activity and brain development

Silva

Arida

2015

Expert Review of Neurotherapeutics

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Brain development is a complex process, and stimuli during this developmental period may modulate the brain's functional maturation and determine its lifelong integrity. Human and animal studies have shown that environmental stimuli such as physical activity habits seem to have a favorable influence on brain development. Research on humans has demonstrated improvement in cognitive performance in the children of women who exercised regularly throughout pregnancy and in individuals who were physically active during childhood and adolescence. Investigations using animal models have also reported that physical activity improves the cognitive function of developing rats. In this review, we will present the neurobiological mechanisms of such effects.

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“…This protocol has moderate intensity. 19 Control rats were immersed in water, carefully dried, and returned to the housing boxes.…”

Section: Swimming Exercise Protocolmentioning

confidence: 99%