Evidências neuroquímicas e comportamentais do efeito ansiogênico da deltametrina em ratos

Abstract

Pyrethroid insecticides are extensively used for pest control around the house, flea prevention for pets, and plant sprays for the home and in agriculture. Deltamethrin (DTM) is a Type II pyrethroid insecticide used to control a variety of insects in agriculture and domestic environments. The present study investigated the possible anxiogenic effects of DTM (1, 3, and 10 mg/kg) in rats using behavioral and neurochemical methods. We assessed general locomotor activity and behavior in the elevated plus maze and open field test. Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) increased striatal serotonin neurotransmitter and its metabolite, and (vii) did not alter motor coordination on the rotarod, grooming duration in the open field test, rectal temperature, or hippocampal neurotransmitter levels. These data suggest that DTM at the present doses and under these experimental conditions presented a similar profile to that of anxiogenic drugs, unrelated with the increased serotonin neurotransmission.Keywords: Deltamethrin. Pyrethroid. Anxiety. Behavior. Central neurotransmitters. ResumoInseticidas piretróides são amplamente utilizados para controle de pragas, como na prevenção de pulgas em animais de estimação e sprays de plantas para a casa e na agricultura. Deltametrina (DTM) é um inseticida piretróide tipo II usado para controlar uma variedade de insetos na agricultura e ambientes domésticos. O presente estudo investigou os possíveis efeitos ansiogênicos de DTM (1, 3 e 10 mg/kg) em ratos, utilizando métodos comportamentais e neuroquímicos. Foi avaliada a atividade locomotora geral e comportamento no labirinto em cruz elevado e teste de campo aberto. Os níveis de neurotransmissores e metabólitos no estriado e hipocampo também foram mensurados. DTM (i) reduziu a locomoção e a frequência de levantar, (ii) aumentou da duração da imobilidade, (iii) reduziu o tempo de interacção social, (iv) reduziu a percentagem de entradas e tempo gasto nos braços abertos do elevado labirinto em cruz, (v) reduziu o número de cruzamentos no centro do labirinto em cruz elevado, (vi) aumentou neurotransmissor serotonina e de seu metabólito estriatal, e (vii) não alterou a coordenação motora no rotarod, duração do grooming no teste de campo aberto, temperatu...

Anxiolytic-Like Effects of Syringic Acid: A Behavioral Study

“…Bhattacharya et al reported that decreased activity after DTM exposure might result from enhanced anxiety because they observed a decreased number of crossings, a decline in time spent in the inner zone, and increased defecation scores in the DTM group (30). Ricci et al reported that behavioral and neurochemical methods induced the anxiogenic effects of DTM in rats, and DTM had a similar effect to anxiogenic drugs via serotonin neurotransmission (31). Similarly, in our study, DTM decreased locomotion, prolonged immobility, rearing repetition, and decreased the time spent in the inner zone.…”

“…The development of anxiety can be strongly influenced by toxicological factors or various activated neurotransmitter mechanisms of DTM. Experimental studies have shown that increased neurotransmitter release at multiple levels in cortical regions improves the efficacy of interconnected networks in anxiety (30,31). A further possible finding is that DTM is responsible for anxiety-related behavioral changes in the marble burying test and OFT; therefore, it can be used to design various experimental models in translational neuroscience.…”