Direct current-biased optical-orthogonal frequency-division multiplexing (DCO-OFDM) is a simple yet spectrally efficient multicarrier modulation scheme for visible light communication (VLC). But in multiple-input multiple-output (MIMO) scenario, which is more practical for VLC due to the LED deployment, the research on DCO-OFDM is still limited and calls for in-depth investigation. In this chapter, we first study the basic modulation scheme of DCO-OFDM, including the design of conventional receiver without considering the clipping noise. Secondly, we present a novel receiver for combating clipping distortion in the DCO-OFDM system, which can reconstruct the clipping noise and subtract it from the received signal. Thirdly, we generalize the results to MIMO scenario and investigate the preliminary transceiver design, which is based on the minimum mean-square error (MMSE) criteria. Based on this, we propose a precoding algorithm to further enhance the performance. Finally, the symbol error rate performance is compared through computer simulations to give the reader a whole picture of the performance of MIMO VLC system.