Evodiae fructus Extract Inhibits Interleukin-1β-Induced MMP-1, MMP-3, and Inflammatory Cytokine Expression by Suppressing the Activation of MAPK and STAT-3 in Human Gingival Fibroblasts In Vitro

Song, Hak Jun; Noh, Eun‐Mi; Kim, Jeong-Mi; You, Yong‐Ouk; Kwon, Kang‐Beom; Lee, Young‐Rae

doi:10.1155/2021/5858393

Cited by 7 publications

(5 citation statements)

References 53 publications

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“…Also, they exhibit antimicrobial efficacy against dental caries and periodontal pathogens, while lowering the development of drug resistance due to their synergistic combinations [ 71 ]. Herbal extracts may also inhibit osteoclast differentiation [ 72 ] as well as the expression of proinflammatory cytokines [ 73 ] and thus suppress bone resorption in periodontitis. The present study is the first systematic review to investigate the effect of herbal dental products compared to conventional products including CHX or placebo in periodontitis patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical Effectiveness of Herbal Oral Care Products in Periodontitis Patients: A Systematic Review

Chatzopoulos

Karakostas

Kavakloglou

et al. 2022

IJERPH

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Background: The use of herbal products in oral cavity has shown an increased popularity and potential benefits due to their additional anti-inflammatory and antioxidant properties as well as the lack of side effects related to their use. Objective: To assess the clinical effectiveness of herbal dental products (mouthwash, dentifrice, gel) when compared to conventional products or placebo in periodontitis patients. Material and methods: A systematic review with 22 studies was carried out using MEDLINE/Pubmed, EMBASE and Web of Science databases in addition to hand searches. Randomized and non-randomized clinical trials that evaluated the effect of any herbal dental product and compared it with conventional products or placebo in periodontitis patients and published up to March 2022, were screened. Results: Herbal products used as adjuncts to scaling and root planing (SRP) or supragingival debridement (SPD) led to superior clinical outcomes than placebo or no adjuncts (8 studies). In conjunction with SRP, these products showed comparable outcomes with chlorhexidine (6 studies) or better (4 studies). When used as adjuncts to SPD, herbal oral care products demonstrated comparable outcomes with chlorhexidine and conventional products (4 studies). Conclusions: Within the limitations of this systematic review, herbal oral care products may play a key role in the management of periodontal disease. Further well-designed studies are needed to establish their efficacy.

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Section: Discussionmentioning

confidence: 99%

Clinical Effectiveness of Herbal Oral Care Products in Periodontitis Patients: A Systematic Review

Chatzopoulos

Karakostas

Kavakloglou

et al. 2022

IJERPH

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“…It has the ability of degrading multiple types of collagen, fibronectin, all actively involved in joint destruction in RA patients ( 25 ). MMP3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9 ( 26 ), indicating that MMP3 plays an important role in the inflammatory responses in RA. Among these pathways, some are involved in atherosclerosis ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

The mechanism of the anti-inflammatory effect of Oldenlandia diffusa on arthritis model rats: a quantitative proteomic and network pharmacologic study

Zhu¹,

Xiong²,

Lü³

et al. 2022

Ann Transl Med

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Background: In China, Oldenlandia diffusa (OD) has been prescribed as a therapeutic herb for rheumatoid arthritis (RA). We previously conducted a preliminary study of the anti-inflammatory effect of OD, and the purpose of this study is to further investigate its mechanism.Methods: We performed a quantitative proteomic analysis of synovium, identified the differentially expressed proteins, and performed bioinformatics analyses. With the help of network pharmacology, we aimed to find the key synovial proteins which OD or its key compound might influence. To verify the result, liquid chromatography-mass spectrometry (LC-MS) was applied to quantify and qualify the absorbable potential compounds of OD. The anti-inflammatory effect was evaluated by morphological, histopathological, and cytokine analyses. Target proteins were observed by immunohistochemistry (IHC) and enzyme-linked immunosorbent assay (ELISA).Results: MMP3 and CAV1 were identified as 2 of the differentially expressed proteins in RA synovium, and might be influenced by quercetin, the active compound of OD. MMP3 might be altered through atherosclerosis signaling, while CAV1 might be altered through caveolar-mediated endocytosis signaling. According to our verification, quercetin was identified as the absorbed and effective compound of OD, and it could exert an anti-inflammatory effect on the collagen induced arthritis (CIA) model, including serum cytokine expression, synovial hyperplasia and lymphocyte infiltration, articular cartilage lesion. Quercetin could also down-regulate the synovial expression of MMP3 and CAV1, and could exert better effects at a high dose.Conclusions: Quercetin was the main active compound of OD in the treatment of RA. OD might alleviate inflammatory responses in CIA rats by suppressing the expression of MMP3 and CAV1 through quercetin, and at a high dose, quercetin could exert a better anti-inflammatory effect.

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“…M1 macrophages activation induces inflammatory mediators production, such as IL-1β, IL-6, IL-8, and TNF-α, and the inducible nitric oxide synthase enzyme (iNOS) [ 52 ], some of these mediators, such as nitric oxide (NO) and IL-8, amplify the inflammatory response by increasing the local blood flow and the recruitment of leukocytes [ 53 , 54 ]. Furthermore, IL-1β and TNF-α increase the expression of matrix metalloproteinases (MMPs), like MMP-1, MMP-13, MMP-8, and MMP-9 [ 40 , 55 ], which have as main substrates collagen I, III, and IV proteins, as well as components of the extracellular matrix, such as fibronectin and tenascin [ 56 ]. These data suggest that the inflammatory mediators favor degradation of the extracellular matrix by MMP activation [ 57 ].…”

Section: Importance Of Macrophages In Periodontitismentioning

confidence: 99%

Macrophages immunomodulation induced by Porphyromonas gingivalis and oral antimicrobial peptides

et al. 2023

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Porphyromonas gingivalis is a keystone pathogen associated with periodontitis development, a chronic inflammatory pathology characterized by the destruction of the supporting teeth structure. Macrophages are recruited cells in the inflammatory infiltrate from patients with periodontitis. They are activated by the P. gingivalis virulence factors arsenal, promoting an inflammatory microenvironment characterized by cytokine production (TNF-α, IL-1β, IL-6), prostaglandins, and metalloproteinases (MMPs) that foster the tissular destruction characteristic of periodontitis. Furthermore, P. gingivalis suppresses the generation of nitric oxide, a potent antimicrobial molecule, through its degradation, and incorporating its byproducts as a source of energy. Oral antimicrobial peptides can contribute to controlling the disease due to their antimicrobial and immunoregulatory activity, which allows them to maintain homeostasis in the oral cavity. This study aimed to analyze the immunopathological role of macrophages activated by P. gingivalis in periodontitis and suggested using antimicrobial peptides as therapeutic agents to treat the disease.

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Evodiae fructus Extract Inhibits Interleukin-1β-Induced MMP-1, MMP-3, and Inflammatory Cytokine Expression by Suppressing the Activation of MAPK and STAT-3 in Human Gingival Fibroblasts In Vitro

Cited by 7 publications

References 53 publications

Clinical Effectiveness of Herbal Oral Care Products in Periodontitis Patients: A Systematic Review

Clinical Effectiveness of Herbal Oral Care Products in Periodontitis Patients: A Systematic Review

The mechanism of the anti-inflammatory effect of Oldenlandia diffusa on arthritis model rats: a quantitative proteomic and network pharmacologic study

Macrophages immunomodulation induced by Porphyromonas gingivalis and oral antimicrobial peptides

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