Evodiamine Induces Cell Growth Arrest, Apoptosis and Suppresses Tumorigenesis in Human Urothelial Cell Carcinoma Cells

Shi, Chung‐Sheng; Li, Jhy-Ming; Chin, Chih‐Chien; Kuo, Yi-Hung; Lee, Ying‐Ray; Huang, Yun‐Ching

doi:10.21873/anticanres.11428

Cited by 34 publications

(12 citation statements)

References 40 publications

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“…The cell cycle analysis has been described previously [ 19 , 20 , 21 ]. Cells (10 6 cells/dish) were seeded in 10-cm cell culture dish for overnight.…”

Section: Methodsmentioning

confidence: 99%

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In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis

Lee

Chen

Lin

et al. 2018

IJMS

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The global incidence of thyroid cancer, one of the most common endocrine malignancies, is especially high among women. Although most patients with thyroid cancers exhibit a good prognosis with standard treatment, there are no effective therapies for patients with anaplastic thyroid cancers or cancers that have reached an advanced or recurrent level. Therefore, it is important to develop highly effective compounds for treating such patients. Aloperine, a natural compound isolated from Sophora alopecuroides, has been reported to possess antioxidant, anti-inflammatory, anti-neuronal injury, anti-renal injury, antitumor, anti-allergic, and antiviral properties. In this study, we show that aloperine can inhibit cell growth in human anaplastic thyroid cancers and multidrug-resistant papillary thyroid cancers. Moreover, it could suppress in vitro tumorigenesis and promote cellular apoptosis. Further analysis demonstrated the involvement of caspase-dependent apoptosis, including intrinsic and/or extrinsic pathways, in aloperine-induced cellular apoptosis. However, cell cycle regulation was not detected with aloperine treatment. This study suggests the potential therapeutic use of aloperine in human anaplastic thyroid cancers and multidrug-resistant papillary thyroid cancers.

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“…The cell cycle analysis has been described previously [ 19 , 20 , 21 ]. Cells (10 6 cells/dish) were seeded in 10-cm cell culture dish for overnight.…”

Section: Methodsmentioning

confidence: 99%

“…Cells were treated with DMSO or aloperine for various durations. The procedure for determining apoptosis was as previously reported [ 19 , 20 , 21 ]. First, cells treated with DMSO or aloperine were stained with PI/Annexin-V (Sigma-Aldrich) and the apoptotic cells were determined by flow cytometry.…”

Section: Methodsmentioning

confidence: 99%

In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis

Lee

Chen

Lin

et al. 2018

IJMS

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“…In addition, evodiamine enhanced TRAIL-induced apoptosis through the regulation of mTOR/S6K1/Mcl-1 pathway [ 144 ]. On the other hand, evodiamine arrested cell cycle progression in G 2 /M phase and increased caspase-dependent apoptosis in bladder tumor cell lines 5637 and HT1197, and the effects of evodiamine was linked with the activations of p38 MAPK and JNK [ 145 ].…”

Section: Pharmacological Activitymentioning

confidence: 99%

Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives

Chang

et al. 2018

IJMS

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Alkaloids, a category of natural products with ring structures and nitrogen atoms, include most U.S. Food and Drug Administration approved plant derived anti-cancer agents. Evodiamine is an alkaloid with attractive multitargeting antiproliferative activity. Its high content in the natural source ensures its adequate supply on the market and guarantees further medicinal study. To the best of our knowledge, there is no systematic review about the antiproliferative effects of evodiamine derivatives. Therefore, in this article the review of the antiproliferative activities of evodiamine will be updated. More importantly, the antiproliferative activities of structurally modified new analogues of evodiamine will be summarized for the first time.

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“…Evodiamine 6 (Figure 4) is a natural quinolone alkaloid widely studied for the treatment of diverse human disorders including Alzheimer’s disease, inflammation and especially cancer (Ogasawara et al, 2002; Yu et al, 2013; Lv et al, 2015; Shi L. et al, 2016; Wang et al, 2016; Wu et al, 2016; Fan et al, 2017; Shi et al, 2017). By targeting topoisomerase I and II, evodiamine has induced apoptosis and cell cycle arrest of a broad spectrum of tumor cell lines (Shyu et al, 2006).…”

Section: Nitrogen Mustard Based Hybridsmentioning

confidence: 99%

Therapeutic Potential of Nitrogen Mustard Based Hybrid Molecules

et al. 2018

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As medicine advances, cancer is still among one of the major health problems, posing significant threats to human health. New anticancer agents features with novel scaffolds and/or unique mechanisms of action are highly desirable for the treatment of cancers, especially those highly aggressive and drug-resistant ones. Nitrogen mustard has been widely used as an anticancer drug since the discovery of its antitumor effect in the 1942. However, the lack of selectivity to cancer cells restricts the wide usage of a mass of nitrogen mustard agents to achieve further clinical significance. Discovery of antitumor hybrids using nitrogen mustards as key functional groups has exhibited enormous potential in the drug development. Introduction of nitrogen mustards resulted in improvement in the activity, selectivity, targetability, safety, pharmacokinetics and pharmacodynamics properties of corresponding lead compounds or agents. Herein, the recently developed nitrogen mustard based hybrids have been introduced in the cancer therapy.

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Evodiamine Induces Cell Growth Arrest, Apoptosis and Suppresses Tumorigenesis in Human Urothelial Cell Carcinoma Cells

Abstract: Evodiamine induces growth inhibition, tumorigenesis suppression, cell-cycle arrest, and apoptosis induction in human UCC cells. Therefore, this agent displays a therapeutic potential for treating human UCC cells and is worthy for further investigation.

Cited by 34 publications

References 40 publications

In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis

In Vitro Antitumor Activity of Aloperine on Human Thyroid Cancer Cells through Caspase-Dependent Apoptosis

Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives

Therapeutic Potential of Nitrogen Mustard Based Hybrid Molecules

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