Evoked potential changes in cats following injection of an extract from the venom sac of the oriental hornet (Vespa orientalis)

Barenholz‐Paniry, Vered; Ishay, Jacob S.; Freeman, Sharon; Sohmer, Haim

doi:10.1016/0041-0101(90)90096-p

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Nearly 4% of soluble proteins of Vespa orientalis are known to contain acetylcholine-like substances (7). The venom and VSE of Vo provoked CNS anticholinesterase-like activity in various animals, and may open the blood-brain barrier and cause central mediated changes in auditory and somatosensory activities in cats (6,24). Snake venom neurotoxins and their effect on central acetylcholine receptors and various ion channels have been reported earlier (25).…”

Section: Discussionmentioning

confidence: 97%

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Mukund

Gawade²

2011

J. Venom. Anim. Toxins incl. Trop. Dis.

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Wasp venom is mixture of complex proteins that have several physical and pharmacological properties. The photochemical detoxification of Vespa orientalis venom is expected to generate photooxidized venom sac extract (PVSE). Antigenically active PVSE is obtained by exposing the venom sac extract (VSE) of Vespa orientalis to ultraviolet radiation in the presence of methylene blue. The aim of the present work was to evaluate the effect of PVSE on learning and memory of rats. Detoxification of PVSE was evident since treated mice had longer survival time than the group of mice treated with VSE. Photooxidized VSE of V. orientalis revealed enhancement on learning and memory by shortening the time to reach food (TRF) in T-maze. In a 28-day study with rats, we observed that PVSE significantly decreased transfer latency (TL) in elevated plus maze (EPM), significantly increased step down latency (SDL), diminished step down errors (SDE) and time spent in shock zone (TSS) in step down avoidance test. Thus, we concluded that although there is a possibility of employing PVSE in the treatment of Alzheimer, dementia or neurodegenerative illness as a non-herbal and non-synthetic alternative for patients who do not respond to available therapy, further investigation is still required.

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Section: Discussionmentioning

confidence: 97%

Untitled

Mukund

Gawade²

2011

J. Venom. Anim. Toxins incl. Trop. Dis.

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“…The intraocular pressure-lowering effect of VSE is most probably not, therefore, directly related to the stimulatory effect of his tamine on ciliary epithelial cell cAMP implied from our tissue culture study. Reduction in intraocular pressure may be due to some other, as yet unknown, effect of venom, perhaps acting upon the central nervous system rather than peripheral sites [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…Due largely to its com plex nature, oriental hornet venom has been shown to have effects in a variety of biological systems. These in clude liver [3], vascular system [4][5][6][7][8], central nervous sys tem [9][10][11], skin [12], muscle [13,14], kidney [15] and devel opment [16].…”

Section: Introductionmentioning

confidence: 99%

Hymenopteran Venom Stimulates Adenylate Cyclase in Cultured Human Cells through a Histamine Receptor

Heath

Ishay

1992

Int Arch Allergy Immunol

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We have examined the effect of venom sac extract (VSE), prepared from two hymenopteran species, on intracellular cyclic AMP (cAMP) accumulation in a cultured human cell line. VSE prepared from the oriental hornet (Vespa orientalis) and from the paper wasp (Polistes Carolina) induced an increase in accumulation of cAMP in human, transformed, non-pigmented, ciliary epithelial cells. The effect of V. orientalis VSE on intracellular cAMP was dose-dependent. Blocking the response of adenylate cyclase-linked β-adrenergic receptors was without effect on this cellular response to VSE. On the other hand, the response to VSE prepared from both species was suppressed almost totally by the H₂-histamine receptor-specific antagonist, cimetidine. The findings are discussed in the light of earlier observations that described a significant reduction in intraocular pressure in vertebrate animals treated with V orientalis VSE.

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“…A large number of stings or alternatively, the experimental injection of a greater quantity of hornet venom provokes a systemic effect and affects also the cardiovascular system (Edery et al 1972;Habermann 1972;Kaplinsky et a/. 1974;Ishay et al 1974b;Barenholz-Paniry et al. 1990).…”

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confidence: 99%

Cardiovascular Haemodynamics of Oriental Hornet Venom Sac Extract

Rubin

Duvdevani

Ishay

1993

Pharmacology & Toxicology

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The effects of hornet venom sac extract on the functioning of the cardiovascular system was assessed in dogs by concomitant examination of the following parameters: Systemic blood pressure, blood pressure and the dp/dt derivative of the left ventricle of the heart, heart rate, direct measurement of the left ventricular wall thickness, cardiac output, and body temperature. The effect of adult hornet venom sac extract on the canine cardiovascular system was rapid and led to a sharp drop in the systemic blood pressure, a similar drop in the pressure and dp/dt derivative in the left ventricle, to bradycardia, immediate thickening of the left ventricular wall and to an immediate rise in the cardiac output. As for the canine temperature, this dropped immediately following the administration of venom sac extract and remained at the new low level for at least 30 min. The smaller molecular weight components (less than 10 kilodalton) in venom sac extract have been found to be responsible for the immediate effects of venom sac extract on the cardiovascular system. On the other hand the high‐molecular weight components exert more delayed effects which lead to a cumulative disturbance of cardiac function.

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Evoked potential changes in cats following injection of an extract from the venom sac of the oriental hornet (Vespa orientalis)

Cited by 4 publications

References 22 publications

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Untitled

Hymenopteran Venom Stimulates Adenylate Cyclase in Cultured Human Cells through a Histamine Receptor

Cardiovascular Haemodynamics of Oriental Hornet Venom Sac Extract

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