Evoked potential changes in patients with Parkinson's disease

Liu, Chunyan; Zhang, Yaping; Tang, Weiguo; Wang, Binda; Wang, Bona; He, Shan

doi:10.1002/brb3.703

Cited by 26 publications

(25 citation statements)

References 16 publications

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“…On the other side, the results of Liu et al [13] study showed that the latencies of P100, N75, and N145 were more delayed in patients with PD than controls, but the amplitude of P100 was not significantly different between the PD patients and control subjects. Despite that, the P100 latency was positively correlated with the disease stage.…”

Section: Discussionmentioning

confidence: 83%

Evaluation of the Visual Pathway in Parkinson’s Disease Patients

Nassar¹,

Al-Malt²,

Nawar³

et al. 2020

J Neurol Exp Neurosci

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Objective: This study aimed to evaluate the visual evoked potentials (VEP) and optical coherence tomography (OCT) as a diagnostic biomarker in Parkinson's disease (PD) patients. Patients and Methods: Forty-seven PD patients were distributed to two groups: Group 1-included 22 newly diagnosed drug naïve PD patients. Group 2-included 25 PD patients receiving antiparkinsonian drugs. Another 20 age and sex-matched healthy subjects were recruited and served as a control group (Group 3). All participants were subjected to full medical history, general and neurological examination. All participants underwent a full neuro-ophthalmologic examination, OCT, and VEP. Results: The VEP assessment revealed that the p100 latency was significantly delayed in patients' groups in comparison to healthy subjects (p < 0.0001). Also, the p100 amplitude was significantly diminished in patients' groups in comparison to healthy subjects (p < 0.0001). These parameters showed statistically significant correlations with both disease duration and severity. There was a significant reduction in both average and quadrant Retinal Nerve Fiber Layer (RNFL) thickness (p < 0.0001) in PD patients compared to healthy subjects, with more affection of group 2. Decreased average RNFL thickness was correlated to PD duration and severity. In PD patients both delayed P100 Latency and decreased amplitude were in a statistically significant correlation with decreased average RNFL thickness. Conclusion: Our results indicate PD patients either drug naïve or medicated show functional and morphological changes in the visual pathway, these changes represent a new biomarker for follow up of PD progression.

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Section: Discussionmentioning

confidence: 83%

Evaluation of the Visual Pathway in Parkinson’s Disease Patients

Nassar¹,

Al-Malt²,

Nawar³

et al. 2020

J Neurol Exp Neurosci

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“…The body mass index (BMI) and educational level were recorded. The unified Parkinson's disease rating scale III (UPDRS‐III) was assessed to identify the severity of PD, and the Hoehn and Yahr (H‐Y) classification was used to determine the stage of PD (Liu et al., ).…”

Section: Methodsmentioning

confidence: 99%

“…Intergroup comparisons of primary data were performed using the Student's t test and nonparametric tests. The Chi‐square test was used to determine group distribution (Liu et al., ). Pearson's correlation test was used to detect the correlation between CPC variables and the PSQI scores in the PD group.…”

Section: Methodsmentioning

confidence: 99%

Assessment of sleep quality using cardiopulmonary coupling analysis in patients with Parkinson's disease

Chen

Liu

et al. 2018

Brain and Behavior

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ObjectivesTo assess the sleep quality of patients with Parkinson's disease (PD) and evaluate the effect of cardiopulmonary coupling (CPC) analysis on sleep quality and its correlation with subjective complaints in patients with PD.MethodsOur study included 42 patients with PD and 30 healthy controls. CPC analysis and the Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the sleep quality of subjects.ResultsHigh‐frequency coupling (HFC) and sleep efficiency were significantly lower in the PD than in the control group, whereas very low‐frequency coupling (VLFC) and sleep latency were significantly higher in the PD than in the control group. PSQI scores were significantly higher in the PD than in the control group (all p < .05). The PSQI score showed a negative correlation with the HFC ratio in the PD group (r = −.478, p = .001). Factors related to the occurrence of PD with poor sleep quality were the unified Parkinson's disease rating scale (UPDRS) score and nocturia.ConclusionsThe sleep quality of patients with PD was generally decreased. CPC analysis can reflect the subjective sleep quality of patients with PD and serve as an effective sleep monitoring tool.

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“…Interestingly, a reduction of the amplitude of b-waves in PD patients is present at early stages of the disease (Ikeda et al, 1994;Nowacka et al, 2015) (Figure 2B). An increase in the latency of the VEP onset is another frequent finding in PD patients (Tartaglione et al, 1987;Liu et al, 2017;He et al, 2018).…”

Section: Pathological Alterations In the Retina Of Pd Patientsmentioning

confidence: 98%