Evoked release of [14C]norepinephrine from the rat hypothalamus during feeding

Martin, G.E.; Myers, R.D.

doi:10.1152/ajplegacy.1975.229.6.1547

Cited by 96 publications

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“…Noradrenaline has been related to arousal and control of feeding behaviour. Studies using push‐pull cannulae have shown NA release in the paraventricular nucleus during food consumption ( Martin and Myers, 1975 ; Paez et al ., 1993 ). The idea that central catecholaminergic neurotransmission is involved in the control of food intake was suggested earlier by the results of Evetts et al .…”

Section: Discussionmentioning

confidence: 99%

α₁‐Adrenoceptors in the lateral septal area modulate food intake behaviour in rats

Scopinho¹,

Resstel²,

Corrêa³

2008

British J Pharmacology

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Background and purpose: Control of food intake is a complex behaviour which involves many interconnected brain structures. The present work assessed if the noradrenergic system in the lateral septum (LS) was involved in the feeding behaviour of rats. Experimental approach: In the first protocol, the food intake of rats was measured. Then non-food-deprived animals received either 100 nL of 21 nmol of noradrenaline or vehicle unilaterally in the LS 10 min after local 10 nmol of WB4101, an a 1 -adrenoceptor antagonist, or vehicle. In the second protocol, different doses of WB4101 (1, 10 or 20 nmol in 100 nL) were microinjected bilaterally into the LS of rats, deprived of food for 18 h and food intake was compared to that of satiated animals. Key results: One-sided microinjection of noradrenaline into the LS of normal-fed rats evoked food intake, compared with vehicle-injected control animals, which was significantly reduced by a 1 -adrenoceptor antagonism. In a further investigation, food intake was significantly higher in food-deprived animals, compared to satiated controls. Pretreatment of the LS with WB4101 reduced food intake in only food-deprived animals in a dose-related manner, suggesting that the LS noradrenergic system was involved in the control of food intake. Conclusion and implications: Activation by local microinjection of noradrenaline of a 1 -adrenoceptors in the LS evoked food intake behaviour in rats. In addition, blockade of the LS a 1 -adrenoceptors inhibited food intake in food-deprived animals, suggesting that the LS noradrenergic system modulated food intake behaviour and satiation.

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Section: Discussionmentioning

confidence: 99%

α₁‐Adrenoceptors in the lateral septal area modulate food intake behaviour in rats

Scopinho¹,

Resstel²,

Corrêa³

2008

British J Pharmacology

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“…Published November 14, 2011. The initial evidence that the noradrenergic circuit is involved in the control of food intake was indicated by the decrease in feeding behavior evoked by the administration of 6-hydroxydopamine into the hypothalamus (1). Studies using a push-pull cannula have shown noradrenaline (NA) release in the paraventricular nucleus during food consumption (2,3). In addition, NA microinjection into hypothalamic nuclei such as the ventromedial hypothalamus and the paraventricular nucleus has been reported to increase food intake in satiated rats (4)(5)(6), whereas injections into more lateral sites including the perifornical region decreased feeding (7).…”

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confidence: 99%

Involvement of β3-adrenergic receptors in the control of food intake in rats

Kanzler

Januário

Paschoalini

2011

Braz J Med Biol Res

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“…The feeding response appears to be mediated through the PVN, since this is the brain region that is most sensitive to NE and since NE-induced feeding is severely attenuated by PVN lesions (12, 16). A role for this system in natural (deprivation-induced) feeding was suggested by the findings that PVN a-adrenergic receptors are down-regulated during fasting and are normalized after eating and by the finding that medial hypothalamic release of NE occurs during spontaneous feeding (17,18).These findings, in conjunction with the localization of NPY in NE neurons and in terminals of the PVN, led us to investigate a role for NPY in feeding. Recently we demonstrated that, like NE, PVN injection of NPY elicits a feeding response in satiated rats (19).…”

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confidence: 99%

Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior.

Stanley¹,

Leibowitz²

1985

Proc. Natl. Acad. Sci. U.S.A.

625

273

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Neuropeptide Y (NPY) was injected directly Into the paraventricular nucleus of the hypothalamus (PVN) of satiated, brain-cannulated rats, and food and water intake were measured 0.5, 1, 2, 4, and 22 hr postinjection. NPY (24, 78, 235, 783, and 2351 pmol/0.3 pl) produced a large, dosedependent increase in food intake as well as a small increase in water intake. The latency to eat was about 10 min, with substantial feeding occurring in the first 30 min. At doses below 78 pmol, the eating generally occurred only within the first hour. At doses above 235 pmol, however, the subjects' food intake continued to increase such that by 4 hr postinjection they had consumed the equivalent of normal 22-hr intake, and 22 hr postinjection they had also eaten significantly more than control subjects. Previous studies have shown that norepinephrine injected into the PVN stimulates feeding through aadrenergic receptors. To investigate a possible interaction, subjects were given PVN injections of phentolamine (60 nmol) prior to injections of either NPY (78 pmol) or norepinephrine (20 nmol). Phentolamine pretreatment significantly decreased feeding elicited by norepinephrine without affecting feeding elicited by NPY. This suggests that NPY does not stimulate feeding through the release of endogenous norepinephrine. The powerful stimulation of feeding elicited by this neuropeptide suggests an important role for hypothalamic NPY, or a structurally related peptide, in the regulation of feeding behavior.Neuropeptide Y (NPY), a 36-amino acid member of the pancreatic polypeptide family, was discovered in porcine brain by Tatemoto et al. in 1982 (1, 2). Subsequently, the concentration of NPY in the brain was found to exceed the concentration of any other peptide (3). Our interest in a possible role for NPY in the control of feeding behavior was stimulat ed by the recent reports that it is colocalized with norepinephrine (NE) and epinephrine in brainstem catecholamine cell groups, which send afferent fibers to the paraventricular nucleus of the hypothalamus (PVN) (4, 5; however, see ref.32), and also by reports that it is found within numerous presynaptic terminals in the PVN (3, 6, 7). Experiments investigating brain mechanisms of feeding behavior have demonstrated that central injections of several putative neurotransmitters, including NE, y-aminobutyric acid, acetylcholine, and opiate agonists, can selectively stimulate feeding behavior (8-11). The most intensely studied of these is NE. It has been shown that PVN injection of exogenous NE, or drug-induced release of endogenous NE from brainstem catecholamine neurons that ascend to the PVN, elicits feeding behavior through stimulation of a2-adrenergic receptors (12-15). The feeding response appears to be mediated through the PVN, since this is the brain region that is most sensitive to NE and since NE-induced feeding is severely attenuated by PVN lesions (12, 16). A role for this system in natural (deprivation-induced) feeding was suggested by the findings that PVN a-adrenergic r...

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Evoked release of [14C]norepinephrine from the rat hypothalamus during feeding

Cited by 96 publications

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α₁‐Adrenoceptors in the lateral septal area modulate food intake behaviour in rats

α₁‐Adrenoceptors in the lateral septal area modulate food intake behaviour in rats

Involvement of β3-adrenergic receptors in the control of food intake in rats

Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior.

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Evoked release of [14C]norepinephrine from the rat hypothalamus during feeding

Cited by 96 publications

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α1‐Adrenoceptors in the lateral septal area modulate food intake behaviour in rats

α1‐Adrenoceptors in the lateral septal area modulate food intake behaviour in rats

Involvement of β3-adrenergic receptors in the control of food intake in rats

Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior.

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Product

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α₁‐Adrenoceptors in the lateral septal area modulate food intake behaviour in rats

α₁‐Adrenoceptors in the lateral septal area modulate food intake behaviour in rats