Evolocumab prevents atrial fibrillation in rheumatoid arthritis rats through restraint of PCSK9 induced atrial remodeling

Han, Xuejie; Gao, Yunlong; He, Meijiao; Luo, Yingchun; Wei, Ying; Duan, Yu; Zhang, Song; Yu, Hui; Kan, Jiuxu; Hou, Te; Zhang, Yun; Li, Yue

doi:10.1016/j.jare.2023.09.007

Cited by 5 publications

(1 citation statement)

References 45 publications

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“…In ammasome and in ammatory signaling pathways involve in the atrial electrical change, calcium handling and structural remodeling [32][33] . In addition, enhancement of in ammation will exacerbate brosis of cardiac broblasts and apoptosis of cardiac myocytes [34][35] . It is clearly that in ammation is key pathology of AF, and anti in ammation can delay the development of AF.…”

Section: Discussionmentioning

confidence: 99%

C-C,N,S treats atrial fibrillation through regulating inflammatory procession: a study of network pharmacology research and gene set enrichment analysis validation

Yang,

Wang,

2023

Preprint

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Triangle drug combination of Citrus medica L.var.sarcodactylis Swingle, Naradostachys jatamansi DC. and Salvia miltiorrhiza Bge. (C-C,N,S) is usually appeared in atrial fibrillation-treating (AF) decoction and has good clinical effects. However, the core pathological process and mechanism of C-C,N,S intervening AF is unclear. So we intend to use network pharmacology and gene set enrichment analysis to explore the potential mechanism. We detected all compounds of C-C,N,S from CNKI database, predicted its bioactive compounds and potential anti-AF targets from related online platforms and databases. Then through PPI network, gene expression analyses, GO and KEGG pathway enrichment analysis on anti-AF targets, we determined the potential mechanism of C-C,N,S treating AF. Finally we used gene set enrichment analysis (GSEA) to validate the therapeutic effect of C-C,N,S. In conclusion, the therapeutic effect of C-C,N,S treating AF was focused on anti-inflammation. C-C,N,S can regulate inflammatory process and inhibit atrial remodeling and fibrosis through regulating TNF signaling pathway, IL-17 signaling pathway (MAPK signaling involved in) and PI3K-Akt signaling pathway. Some genes regulated by specific herbal medicine explained reason of the combination.

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