Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs

Li, Zhiwen; Guo, Zhihao; Lü, Xi; Ma, Xican; Wang, Xiukun; Zhang, Rui; Hu, Xinxin; Wang, Yanxiang; Pang, Jing; Fan, Tianyun; Liu, Yonghua; Tang, Sheng; Fu, Haigen; Zhang, Jingpu; Li, Yinghong; You, Xuefu; Song, Dan–Qing

doi:10.1016/j.apsb.2023.03.002

Acta Pharmaceutica Sinica B

2023

DOI: 10.1016/j.apsb.2023.03.002

|View full text |Cite

Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs

Zhiwen Li

Zhihao Guo

Xi Lü

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Organophotocatalyst Enabled Deoxycyclopropanation of Alcohols

Zhang,

Wang,

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Cyclopropane fragments, which widely exist in marketed drugs and natural products, can confer special pharmacological properties to small‐molecule drugs. Therefore, developing methods to construct cyclopropanes is of great significance. Nevertheless, the introduction of cyclopropane primarily relies on already‐formed cyclopropyl groups, which significantly restricts the diversity of cyclopropane skeletons. Late‐stage direct cyclopropanation is still a challenging task. Herein, a photo‐induced intermolecular deoxycyclopropanation reaction that employs alcohols as substrates, and 1 mol.% of 2,3,5,6‐tetrakis(carbazol‐9‐yl)‐1,4‐dicyanobenzene (4CzTPN) as organophotocatalyst is reported. This method proceeds with high transformation efficiency (up to 98% yield) and exhibits broad functional group tolerance, such as primary, secondary, and tertiary alcohols as well as various activated β‐halogenated alkenes. This process is mild, easy to operate, and has low equipment requirements. The power of this technology is demonstrated by the late‐stage functionalization of five marketed drugs and five natural products.

show abstract

Organophotocatalyst Enabled Deoxycyclopropanation of Alcohols

Zhang,

Wang,

et al. 2024

Advanced Science

View full text Add to dashboard Cite

show abstract

Lycorine esters exert anti-HCoV-OC43 effect through reversibly acylating cysteine residue in the nsp 12 NiRAN domain

Mei,

Yu,

Gong

et al. 2024

Bioorganic Chemistry

View full text Add to dashboard Cite

Synthesis of peptidomimetics as antibiotic adjuvants for combination with aztreonam to combat MDR Pseudomonas aeruginosa

Ma,

Guo,

Zhu

et al. 2023

European Journal of Medicinal Chemistry

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs

Cited by 5 publications

References 30 publications

Organophotocatalyst Enabled Deoxycyclopropanation of Alcohols

Organophotocatalyst Enabled Deoxycyclopropanation of Alcohols

Lycorine esters exert anti-HCoV-OC43 effect through reversibly acylating cysteine residue in the nsp 12 NiRAN domain

Synthesis of peptidomimetics as antibiotic adjuvants for combination with aztreonam to combat MDR Pseudomonas aeruginosa

Contact Info

Product

Resources

About