Evolution and diversity of cadherins and catenins

Gul, Ismail Sahin; Hulpiau, Paco; Saeys, Yvan; Roy, Frans Van

doi:10.1016/j.yexcr.2017.03.001

Cited by 126 publications

(110 citation statements)

References 43 publications

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“…Cadherins are a superfamily of more than 100 Ca 2+ ‐dependent cell–cell adhesion molecules (Angst, Marcozzi, & Magee, 2001; Gul, Hulpiau, Saeys, & van Roy, 2017; Kemler, Ozawa, & Ringwald, 1989; Koch, Bozic, Pertz, & Engel, 1999; Nollet, Kools, & van Roy, 2000; Yagi & Takeichi, 2000). These transmembrane glycoproteins (Figure 3) have many important roles in cell–cell contact and cell signaling during tissue morphogenesis and also in the maintenance of tissue homeostasis (Gallin, 1998; Gumbiner, 1996; Leckband & Sivasankar, 2012; Maitre & Heisenberg, 2013; Mohamet, Hawkins, & Ward, 2011; Niessen, Leckband, & Yap, 2011; Takeichi, 1995, 1988; Tiwari et al 2018).…”

Section: Families Of Adhesion Moleculesmentioning

confidence: 99%

“…The intracellular tail, which is most highly conserved, binds with catenins (α‐ and β‐catenins) which, in turn, interact with the actin cytoskeleton (Gooding, Yap, & Ikura, 2004; Gul et al, 2017; Kemler et al, 1989; Ranscht, 1994; Takeichi, 2014; Yap, Brieher, & Gumbiner, 1997; Figure 3). This creates molecular links whereby the intracellular region of cadherins can influence the activity of the extracellular region (Nagafuchi & Takeichi, 1988; Kintner, 1992).…”

Section: Families Of Adhesion Moleculesmentioning

confidence: 99%

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Adhesion molecules in gamete transport, fertilization, early embryonic development, and implantation—role in establishing a pregnancy in cattle: A review

D’Occhio

Campanile

Zicarelli

et al. 2020

Molecular Reproduction Devel

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Cell–cell adhesion molecules have critically important roles in the early events of reproduction including gamete transport, sperm–oocyte interaction, embryonic development, and implantation. Major adhesion molecules involved in reproduction include cadherins, integrins, and disintegrin and metalloprotease domain‐containing (ADAM) proteins. ADAMs on the surface of sperm adhere to integrins on the oocyte in the initial stages of sperm–oocyte interaction and fusion. Cadherins act in early embryos to organize the inner cell mass and trophectoderm. The trophoblast and uterine endometrial epithelium variously express cadherins, integrins, trophinin, and selectin, which achieve apposition and attachment between the elongating conceptus and uterine epithelium before implantation. An overview of the major cell–cell adhesion molecules is presented and this is followed by examples of how adhesion molecules help shape early reproductive events. The argument is made that a deeper understanding of adhesion molecules and reproduction will inform new strategies that improve embryo survival and increase the efficiency of natural mating and assisted breeding in cattle.

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Section: Families Of Adhesion Moleculesmentioning

confidence: 99%

Section: Families Of Adhesion Moleculesmentioning

confidence: 99%

Adhesion molecules in gamete transport, fertilization, early embryonic development, and implantation—role in establishing a pregnancy in cattle: A review

D’Occhio

Campanile

Zicarelli

et al. 2020

Molecular Reproduction Devel

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“…The transmembrane protein vascular endothelial‐cadherin (VE‐cadherin) exists in the central nervous system endothelium . VE‐cadherin belongs to the cadherin superfamily which is involved in cell‐cell adhesion and signaling . Moreover, it has been recognized that cadherin plays a critical role in the formation of hydrocephalus .…”

Section: Introductionmentioning

confidence: 99%

Thrombin disrupts vascular endothelial‐cadherin and leads to hydrocephalus via protease‐activated receptors‐1 pathway

Hao

Zhang

et al. 2019

CNS Neurosci Ther

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Summary Aims Previous studies indicated that intraventricular injection of thrombin would induce hydrocephalus. But how thrombin works in this process remains unclear. Since cadherin plays a critical role in hydrocephalus, we aimed to explore the mechanisms of how thrombin acted on choroid plexus vascular endothelium and how thrombin interacted with vascular endothelial‐cadherin (VE‐cadherin) during hydrocephalus. Methods There were two parts in this study. Firstly, rats received an injection of saline or thrombin into the right lateral ventricle. Magnetic resonance imaging was applied to measure the lateral ventricle volumes. Albumin leakage and Evans blue content were assessed to test the blood‐brain barrier function. Immunofluorescence and Western blot were applied to detect the location and the expression of VE‐cadherin. Secondly, we observed the roles of protease‐activated receptors‐1 (PAR1) inhibitor (SCH79797), Src inhibitor (PP2), p21‐activated kinase‐1 (PAK1) inhibitor (IPA3) in the thrombin‐induced hydrocephalus, and their effects on the regulation of VE‐cadherin. Results Our study demonstrated that intraventricular injection of thrombin caused significant downregulation of VE‐cadherin in choroid plexus and dilation of ventricles. In addition, the inhibition of PAR1/p‐Src/p‐PAK1 pathway reversed the decrease of VE‐cadherin and attenuated thrombin‐induced hydrocephalus. Conclusions Our results suggested that the thrombin‐induced hydrocephalus was associated with the inhibition of VE‐cadherin via the PAR1/p‐Src/p‐PAK1 pathway.

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“…So, too does the finding of alpha‐catenins being more relatively abundant in buttock than sun‐exposed dorsal forearm skin. These proteins are actin filament‐associated proteins and important in maintaining cellular adhesion via β ‐catenin and E‐cadherin through the actin network . A reduction of alpha‐catenin 1 is associated with an increase in NF‐ κ B activation and hyperproliferation , again suggesting differences in the actin network and differences in the number and properties of adherence junctions in buttock skin compared with forearm skin.…”

Section: Discussionmentioning

confidence: 99%

Mass spectrometry‐based proteomics reveals the distinct nature of the skin proteomes of photoaged compared to intrinsically aged skin

Newton

Riba-Garcia

Griffiths

et al. 2019

Intern J of Cosmetic Sci

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Objective With increasing age, skin is subject to alterations in its organization, which impact on its function as well as having clinical consequences. Proteomics is a useful tool for non‐targeted, semi‐quantitative simultaneous investigation of high numbers of proteins. In the current study, we utilize proteomics to characterize and contrast age‐associated differences in photoexposed and photoprotected skin, with a focus on the epidermis, dermal–epidermal junction and papillary dermis. Methods Skin biopsies from buttock (photoprotected) and forearm (photoexposed) of healthy volunteers (aged 18–30 or ≥65 years) were transversely sectioned from the stratum corneum to a depth of 250 μm. Following SDS‐PAGE, each sample lane was segmented prior to analysis by liquid chromatography‐mass spectrometry/mass spectrometry. Pathway analysis was carried out using Ingenuity IPA. Results Comparison of skin proteomes at buttock and forearm sites revealed differences in relative protein abundance. Ageing in skin on the photoexposed forearm resulted in 80% of the altered proteins being increased with age, in contrast to the photoprotected buttock where 74% of altered proteins with age were reduced. Functionally, age‐altered proteins in the photoexposed forearm were associated with conferring structure, energy and metabolism. In the photoprotected buttock, proteins associated with gene expression, free‐radical scavenging, protein synthesis and protein degradation were most frequently altered. Conclusion This study highlights the necessity of not considering photoageing as an accelerated intrinsic ageing, but as a distinct physiological process.

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Evolution and diversity of cadherins and catenins

Cited by 126 publications

References 43 publications

Adhesion molecules in gamete transport, fertilization, early embryonic development, and implantation—role in establishing a pregnancy in cattle: A review

Adhesion molecules in gamete transport, fertilization, early embryonic development, and implantation—role in establishing a pregnancy in cattle: A review

Thrombin disrupts vascular endothelial‐cadherin and leads to hydrocephalus via protease‐activated receptors‐1 pathway

Mass spectrometry‐based proteomics reveals the distinct nature of the skin proteomes of photoaged compared to intrinsically aged skin

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