Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective

Lv, Yan; Pang, Xuan; Cao, Zhonghong; Song, Changping; Liu, Baohua; Wu, Weiwei; Pang, Qiuxiang

doi:10.3390/ijms25063322

Cited by 4 publications

(1 citation statement)

References 249 publications

(309 reference statements)

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“…Notch signaling is essential for neural stem cell maintenance and neurogenesis in both the embryonic and adult brains [6]. The elderly's brain function, cell differentiation, and neurite formation are all impacted by Notch signaling, which is crucial for the nervous system's regular operation [5,25]. Accordingly, multiple mutations in Notch proteins have been linked to neurodegenerative conditions [21].…”

Section: Introductionmentioning

confidence: 99%

SNP and Structural Study of the Notch Superfamily Provides Insights and Novel Pharmacological Targets against the CADASIL Syndrome and Neurodegenerative Diseases

Papageorgiou,

Papa,

Papakonstantinou

et al. 2024

Genes

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The evolutionary conserved Notch signaling pathway functions as a mediator of direct cell–cell communication between neighboring cells during development. Notch plays a crucial role in various fundamental biological processes in a wide range of tissues. Accordingly, the aberrant signaling of this pathway underlies multiple genetic pathologies such as developmental syndromes, congenital disorders, neurodegenerative diseases, and cancer. Over the last two decades, significant data have shown that the Notch signaling pathway displays a significant function in the mature brains of vertebrates and invertebrates beyond neuronal development and specification during embryonic development. Neuronal connection, synaptic plasticity, learning, and memory appear to be regulated by this pathway. Specific mutations in human Notch family proteins have been linked to several neurodegenerative diseases including Alzheimer’s disease, CADASIL, and ischemic injury. Neurodegenerative diseases are incurable disorders of the central nervous system that cause the progressive degeneration and/or death of brain nerve cells, affecting both mental function and movement (ataxia). There is currently a lot of study being conducted to better understand the molecular mechanisms by which Notch plays an essential role in the mature brain. In this study, an in silico analysis of polymorphisms and mutations in human Notch family members that lead to neurodegenerative diseases was performed in order to investigate the correlations among Notch family proteins and neurodegenerative diseases. Particular emphasis was placed on the study of mutations in the Notch3 protein and the structure analysis of the mutant Notch3 protein that leads to the manifestation of the CADASIL syndrome in order to spot possible conserved mutations and interpret the effect of these mutations in the Notch3 protein structure. Conserved mutations of cysteine residues may be candidate pharmacological targets for the potential therapy of CADASIL syndrome.

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Section: Introductionmentioning

confidence: 99%

SNP and Structural Study of the Notch Superfamily Provides Insights and Novel Pharmacological Targets against the CADASIL Syndrome and Neurodegenerative Diseases

Papageorgiou,

Papa,

Papakonstantinou

et al. 2024

Genes

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The Molecular Mechanism of Embryonic Development in Decapod Crustaceans

Farhadi,

Zhao,

Tan

2024

Reviews in Aquaculture

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In recent decades, the decapod aquaculture industry has grown significantly in many parts of the world. Despite this progress, production levels still fall short of market demands, indicating a need for further efforts to increase the production. Investigations into the molecular mechanisms underlying embryonic development in decapods provide valuable insights into the complex embryonic development processes of this economically and ecologically important animal group. In this review, we explore the molecular mechanisms underlying decapod embryonic development, focusing on key genes, signaling pathways, and microRNAs (miRNAs) involved in the embryogenesis. Numerous genes have been identified that regulate various aspects of embryogenesis including egg activation, maternal‐to‐zygotic transition (MZT), mesoderm development, segmentation, nervous system development, sex determination, germline development, and exoskeleton formation. We also discuss the pivotal role of signaling pathways such as Hedgehog, Wnt, Notch, MAPK, TGF‐β, Jak‐STAT, VEGF, and Ecdysteroid in the regulation of embryogenesis. Additionally, this review identifies current research gaps in decapod embryogenesis and proposes directions for future investigation. This review is anticipated to be especially beneficial for researchers delving into the molecular mechanisms driving embryonic development in decapods.

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An Orthologics Study of the Notch Signaling Pathway

Stein

2024

Genes

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The Notch signaling pathway plays a major role in embryological development and in the ongoing life processes of many animals. Its role is to provide cell-to-cell communication in which a Sender cell, bearing membrane-embedded ligands, instructs a Receiver cell, bearing membrane-embedded receptors, to adopt one of two available fates. Elucidating the evolution of this pathway is the topic of this paper, which uses an orthologs approach, providing a comprehensive basis for the study. Using BLAST searches, orthologs were identified for all the 49 components of the Notch signaling pathway. The historical time course of integration of these proteins, as the animals evolved, was elucidated. Insofar as cell-to-cell communication is of relevance only in multicellular animals, it is not surprising that the Notch system became functional only with the evolutionary appearance of Metazoa, the first multicellular animals. Porifera contributed a quarter of the Notch pathway proteins, the Cnidaria brought the total to one-half, but the system reached completion only when humans appeared. A literature search elucidated the roles of the Notch system’s components in modern descendants of the ortholog-contributing ancestors. A single protein, the protein tyrosine kinase (PTK) of the protozoan Ministeria vibrans, was identified as a possible pre-Metazoan ancestor of all three of the Notch pathway proteins, DLL, JAG, and NOTCH. A scenario for the evolution of the Notch signaling pathway is presented and described as the co-option of its components, clade by clade, in a repurposing of genes already present in ancestral unicellular organisms.

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Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective

Cited by 4 publications

References 249 publications

SNP and Structural Study of the Notch Superfamily Provides Insights and Novel Pharmacological Targets against the CADASIL Syndrome and Neurodegenerative Diseases

SNP and Structural Study of the Notch Superfamily Provides Insights and Novel Pharmacological Targets against the CADASIL Syndrome and Neurodegenerative Diseases

The Molecular Mechanism of Embryonic Development in Decapod Crustaceans

An Orthologics Study of the Notch Signaling Pathway

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