Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole

Qi, Biying; Yu, Yanping; You, Qi Sheng; Wang, Zengyi; Wang, Jing; Liu, Lingzi; Liu, Wu

doi:10.1007/s00417-020-04814-5

Cited by 4 publications

(7 citation statements)

References 23 publications

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“…5,6 In most cases, this tissue formed a bridge over the retinal pigment epithelium, resembling an OFL that was described in our previous study. 23 According to that study, 23 the presence of OFL may have no negative effect on postoperative outcomes and represents a remodeling process of foveal photoreceptors. 23 In this study, a significantly lower frequency of OFL was found in eyes with EP at 10 months postoperatively.…”

Section: Discussionmentioning

confidence: 97%

“…23 According to that study, 23 the presence of OFL may have no negative effect on postoperative outcomes and represents a remodeling process of foveal photoreceptors. 23 In this study, a significantly lower frequency of OFL was found in eyes with EP at 10 months postoperatively. In eyes with EP, because a more intact EZ was also obtained at 10 months, we hypothesized that active migration and proliferation of Müller cells, which is associated with the presence of EP, may result in faster recovery of the outer retinal layers, thereby leading to a lower percentage of OFLs at 10 months.…”

Section: Discussionmentioning

confidence: 97%

“…OFL is defined as an outer foveolar hyporeflective space lying between the retinal pigment epithelium and the external limiting membrane (Figure 2B). 23…”

Section: Methodsmentioning

confidence: 99%

“…OFL is defined as an outer foveolar hyporeflective space lying between the retinal pigment epithelium and the external limiting membrane (Figure 2B). 23 Using the embedded OCT caliper function, MLD, base diameter (BD), macular hole height, length of the disrupted outer retinal layers before and after surgery, and postoperative central foveal thickness (CFT) were measured. MLD was defined as the narrowest diameter between the two macular hole edges on the largest cross-section.…”

Section: Oct Evaluations and Measurementsmentioning

confidence: 99%

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Clinical Characteristics and Surgical Prognosis of Idiopathic Macular Holes With Epiretinal Proliferation

Yang

et al. 2023

Retina

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Purpose: To investigate the clinical features and surgical outcomes of idiopathic macular holes with epiretinal proliferation (EP).Methods: This retrospective study included 282 eyes of 269 consecutive patients who underwent vitrectomy for idiopathic macular holes. Clinical demographic data, baseline and postoperative retinal microstructure features on optical coherence tomography images, best-corrected visual acuity, and postoperative closure rate were compared between eyes with and without EP.Results: EP was identified in 38 of 282 eyes (13.5%). Eyes with EP had a significantly longer symptom duration (P = 0.019), higher frequency of pseudophakic conditions (P = 0.034), presence of epiretinal membrane (P , 0.001), and a larger base diameter (P = 0.014) than those without EP. In addition, compared with eyes without EP, those with EP had a higher percentage of U-type closure (P = 0.047) and a thicker central fovea (P = 0.012) at 1 month postoperatively and a significantly lower frequency of ellipsoid zone disruption (P = 0.033) and outer foveolar lucency (P = 0.021) and a thicker central fovea (P = 0.004) at 10 months postoperatively. Conclusion:The presence of EP represents a more chronic pathogenic process but has no negative effect on postoperative outcomes and can even facilitate anatomical recovery after surgery.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

“…OFL is defined as an outer foveolar hyporeflective space lying between the retinal pigment epithelium and the external limiting membrane (Figure 2B). 23…”

Section: Methodsmentioning

confidence: 99%

Section: Oct Evaluations and Measurementsmentioning

confidence: 99%

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Clinical Characteristics and Surgical Prognosis of Idiopathic Macular Holes With Epiretinal Proliferation

Yang

et al. 2023

Retina

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“…In 2010, Michalewska et al reported the application of inverted ILM flap technique to MHs with a diameter over 500 μ m [ 7 ] and its satisfactory efficacy in improving VA and closure rate of IMH and myopic MHs [ 7 ]. A large-scale comparative study found that the closure rate was 95.6% and 88.4% in patients with IMH >400 μ m and myopic MH after the application of the inverted ILM flap technique [ 9 ]. Compared with ILM implantation technology, inverted ILM flap technology can better restore the photosensitive layer and obtain better functional results.…”

Section: Introductionmentioning

confidence: 99%

Clinical Observation of Anatomical and Visual Outcomes of Macular Hole after Inverted Internal Limiting Membrane Flap in Patients with Idiopathic Macular

Zhang

Yue

et al. 2023

Journal of Healthcare Engineering

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Objective. To investigate anatomical and visual outcomes of macular hole (MH) after inverted internal limiting membrane (ILM) flap technique for idiopathic macular hole (IMH). Methods. A total of 13 IMH cases diagnosed in Shanxi Eye Hospital between January 2015 and June 2016 were included in the study. All patients underwent vitrectomy combined with indocyanine green-assisted inverted ILM flap technique. The MH closure rate, best-corrected visual acuity (BCVA), changes of ellipsoid zone (EZ), and external limiting membrane (ELM) were examined before operation and one, three, and six months after operation. Furthermore, 488 nm fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT) were used to observe the dynamic changes in function of macular area after surgery. Results. One month after the surgery, the MH closure rate was 100% and the visual acuity (VA) was stable, with no recurrence. Additionally, the average logMAR BCVA before operation was 1.208 ± 0.158, and this value became 0.877 ± 0.105 one month after the operation, showing a significant decrease. Three months after surgery, the average logMAR BCVA was 0.792 ± 0.103, which was significantly lower than the level one month after the surgery but much higher than that six months after surgery (0.708 ± 0.131). Besides, the diameter of the EZ defect of the postoperative one month, three months, and six months was (1377.46 ± 198.65) μm, (964.62 ± 336.26) μm, and (817.08 ± 442.99) μm, respectively. In postoperative one month, three months, and six months, the diameter of the ELM defect diameter was (969.62 ± 189.92) μm, (649.92 ± 413.15) μm, and (557.62 ± 412.50) μm, respectively. The diameter of both EZ and ELM defects was significantly reduced with the passage of time after surgery. Conclusion. Inverted ILM flap technique can reconstruct macular anatomical structure and improve VA. This technique is effective for the treatment of IMH with large MH minimum diameter and base diameter.

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Macular hole closure patterns: an updated classification

Rossi

Bacherini

Caporossi

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole

Cited by 4 publications

References 23 publications

Clinical Characteristics and Surgical Prognosis of Idiopathic Macular Holes With Epiretinal Proliferation

Clinical Characteristics and Surgical Prognosis of Idiopathic Macular Holes With Epiretinal Proliferation

Clinical Observation of Anatomical and Visual Outcomes of Macular Hole after Inverted Internal Limiting Membrane Flap in Patients with Idiopathic Macular

Macular hole closure patterns: an updated classification

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