living entities were simple natural elements, namely the air, the water, the fire and the earth. Anaximander held the very original view that the infinite (apeiron) created everything on earth and it was the unique generating power of cosmogony, offering therefore a reasonable explanation of the existence of everything in the world. 3 According to Anaximander the apeiron is a boundless lasting stuff, an eternal substance, infinite, unaltered, incorruptible, everlasting (aidion), indestructible, immortal (athanaton) and inexperienced, which acts as the unique generating energy, without any limitation of time and space, steering all the natural phenomena. 4 The apeiron is therefore the source of creativity, it is the origin (ἀρχή) of each existent entity, 5 the real cause of the continuous evolution of the living world and of frequent alterations of the biological systems. Many centuries before Darwin (1859) 6 who suggested that species evolve, Anaximander claimed that the evolution affected all living beings and described the evolution of the animals, that arising in a water environment, being covered with spiny skin, crawled later onto land and survived under continuous transfiguration.