Evolution de l'histamine plasmatique après midazolam chez les sujets à risque d'histaminolibération

Laxenaire, M; Borgo, J; Menu, N.; Holzer, J; Royer, R.

doi:10.1016/s0750-7658(85)80208-2

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…However, a small increase in plasma histamine levels [74] and hemodynamic changes have been described after the administration of midazolam and diazepam [76]. When we evaluated the in vitro effects of three benzodiazepinesdiazepam, flunitrazepam and midazolam -on the release of mediators from human basophils and mast cells isolated from lung parenchyma and skin tissues, we found that flu nitrazepam had no releasing activity on basophils and mast…”

Section: Benzodiazepinesmentioning

confidence: 96%

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Role of Mast Cells, Basophils and Their Mediators in Adverse Reactions to General Anesthetics and Radiocontrast Media

Genovese

Stellato

Marsella

et al. 1996

Int Arch Allergy Immunol

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General anesthetics and radiocontrast media (RCM) can cause anaphylactic or anaphylactoid reactions. These are usually underdiagnosed and underreported, but their incidence is apparently rising. Their pathogenesis is complex and not completely understood, but the release of vasoactive mediators from basophils and mast cells plays a central role. The recent development of in vitro techniques to study the release of preformed (histamine and tryptase) and de novo synthesized mediators (PGD₂, LTC₄, and PAF) from purified basophils and mast cells has made it possible to quantify the mediator-releasing activity of anesthetics such as muscle relaxants, general anesthetics, opioids, and benzodiazepines and RCM on human basophils and mast cells isolated from lung, skin and heart tissues. The majority of general anesthetics and RCM tested induced only the release of preformed mediators (histamine and tryptase), not of the de novo synthesized eicosanoids. There was wide variability in the response of basophils and mast cells from different donors to the same drug or RCM, presumably due to the releasability parameter. Hyperosmolality is probably not the only factor responsible for basophil and mast cell activation by RCM. The in vitro release of histamine induced by anesthetic drugs and RCM was correlated with the release of tryptase. Given the longer half-life of tryptase than histamine in plasma, measurements of plasma tryptase may become a useful diagnostic tool for identifying adverse reactions to anesthetics and RCM.

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Section: Benzodiazepinesmentioning

confidence: 96%

“…Benzodiazepines, used for premedication and induction of general anesthesia [73], are relatively safe in vivo [74,75]. However, a small increase in plasma histamine levels [74] and hemodynamic changes have been described after the administration of midazolam and diazepam [76].…”

Section: Benzodiazepinesmentioning

confidence: 99%

Role of Mast Cells, Basophils and Their Mediators in Adverse Reactions to General Anesthetics and Radiocontrast Media

Genovese

Stellato

Marsella

et al. 1996

Int Arch Allergy Immunol

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Histamine release “in vivo” and “in vitro” induced by hypnotics in normal and atopic patients

Laxenaire¹,

Guéant²,

Moneret-Vautrin³

1992

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Anesthetic considerations in pediatric mastocytosis: a review

Klein

Misseldine

2013

J Anesth

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Mastocytosis is an orphan disease rarely encountered by practicing anesthesiologists. Children with mastocytosis often present for procedures or surgery requiring anesthesia. Because many of the medications commonly used in pediatric anesthesia have been reported to initiate mast cell activation, parents are often very anxious about their child's perioperative experience. Laboratory investigations of serum histamine assays associated with different anesthetic drugs have not been shown to predict mast cell degranulation in these patients. However, the pediatric literature suggests that children with disease limited to the skin rarely suffer serious side effects from anesthesia, and there are no reported fatalities. Preoperative prophylaxis is usually based on expert opinion and case reports. Detailed tables summarizing reports of anesthetic medications used for children with mastocytosis undergoing anesthesia, reported side effects, and suggested prophylaxis regimens are included in this review.

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Evolution de l'histamine plasmatique après midazolam chez les sujets à risque d'histaminolibération

Cited by 5 publications

References 7 publications

Role of Mast Cells, Basophils and Their Mediators in Adverse Reactions to General Anesthetics and Radiocontrast Media

Role of Mast Cells, Basophils and Their Mediators in Adverse Reactions to General Anesthetics and Radiocontrast Media

Histamine release “in vivo” and “in vitro” induced by hypnotics in normal and atopic patients

Anesthetic considerations in pediatric mastocytosis: a review

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