Introduction: Kidney transplantation from living donors is increasing, and living donor selection criteria must be strict to ensure the safety of donors. Materials and methods: It is a single center retrospective study over a period of 7 years. Results: There are 43 challenged donors. The average age is 43.9, of whom 58.3% are women, the applicants for the donation were essentially from 44.4% ascendants, and the causes of donor exclusion were: the presence of donorspecific anti-HLA antibodies, positive cross-match, age limit, diabetes, arterial hypertension, obesity, disturbed renal morphological abnormalities and vascular abnormalities Conclusions: The selection criteria for living relatives have been expanded to increase the chances of receiving a kidney; however, some contraindications remain incontestable.