Evolution in the Fast Lane: Rapidly Evolving Sex-Related Genes in Drosophila

Haerty, Wilfried; Jagadeeshan, Santosh; Kulathinal, Rob J.; Wong, Alex; Ram, K. Ravi; Sirot, Laura K.; Levesque, Lisa; Artieri, Carlo G.; Wolfner, Mariana F.; Civetta, Alberto; Singh, Rama S.

doi:10.1534/genetics.107.078865

Cited by 356 publications

(437 citation statements)

References 97 publications

Supporting

Mentioning

394

Contrasting

Unclassified

Order By: Relevance

“…Positive selection seems to be at least partially responsible for these patterns, because genes involved in spermatogenesis have significantly stronger evidence for positive selection than do nonspermatogenesis genes (permutation test, P 5 0.0053). Similarly, genes that encode components of seminal fluid have significantly stronger evidence for positive selection than 'non-sex' genes 139 . Moreover, protein-coding genes involved in male reproduction, especially seminal fluid and testis genes, are particularly likely to be lost or gained across Drosophila species 29,139 .…”

Section: Articlesmentioning

confidence: 99%

Evolution of genes and genomes on the Drosophila phylogeny

Clark¹,

Eisen²,

Smith³

et al. 2007

Nature

1,826

1,041

View full text Add to dashboard Cite

Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.

show abstract

Section: Articlesmentioning

confidence: 99%

Evolution of genes and genomes on the Drosophila phylogeny

Clark¹,

Eisen²,

Smith³

et al. 2007

Nature

1,826

1,041

View full text Add to dashboard Cite

show abstract

“…Both genes are part of a gene family that diversified during insect evolution forming four primary clades for each gene family [49]. While reproductive genes often evolve rapidly [122,123], the tubulins are highly conserved at the protein level. In fact, there is not a single amino acid difference in the axonemal b-tubulin across all Drosophila species, a taxonomic range that spans approximately 60 million years [124].…”

Section: Stalk-eyed Fly Genomicsmentioning

confidence: 99%

Gene duplication, tissue-specific gene expression and sexual conflict in stalk-eyed flies (Diopsidae)

Baker

Narechania

Johns

et al. 2012

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

Gene duplication provides an essential source of novel genetic material to facilitate rapid morphological evolution. Traits involved in reproduction and sexual dimorphism represent some of the fastest evolving traits in nature, and gene duplication is intricately involved in the origin and evolution of these traits. Here, we review genomic research on stalk-eyed flies (Diopsidae) that has been used to examine the extent of gene duplication and its role in the genetic architecture of sexual dimorphism. Stalk-eyed flies are remarkable because of the elongation of the head into long stalks, with the eyes and antenna laterally displaced at the ends of these stalks. Many species are strongly sexually dimorphic for eyespan, and these flies have become a model system for studying sexual selection. Using both expressed sequence tag and next-generation sequencing, we have established an extensive database of gene expression in the developing eye-antennal imaginal disc, the adult head and testes. Duplicated genes exhibit narrower expression patterns than nonduplicated genes, and the testes, in particular, provide an abundant source of gene duplication. Within somatic tissue, duplicated genes are more likely to be differentially expressed between the sexes, suggesting gene duplication may provide a mechanism for resolving sexual conflict.

show abstract

“…aegypti male mRGPs, we used a bioinformatic approach. Even though primary sequences of reproductive proteins are often rapidly evolving (Swanson et al, 2001;Swanson and Vacquier, 2002;Holloway and Begun, 2004;Mueller et al, 2005;Andrés et al, 2006;Haerty et al, In press), the fact that some appear to be conserved (e.g., Drosophila sex peptide has activity in a moth (Fan et al, 1999;Nagalakshmi et al, 2004) made it important to begin with sequence comparisons to identify Ae. aegypti homologs.…”

Section: Detection Of Ae Aegypti Homologs Of D Melanogaster Male Acmentioning

confidence: 99%

Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction

Sirot

Poulson

McKenna

et al. 2008

Insect Biochemistry and Molecular Biology

155

166

View full text Add to dashboard Cite

Male reproductive gland proteins (mRGPs) impact the physiology and/or behavior of mated females in a broad range of organisms. We sought to identify mRGPs of the yellow fever mosquito, Aedes aegypti, the primary vector of dengue and yellow fever viruses. Earlier studies with Ae. aegypti demonstrated that "matrone" (a partially purified male reproductive accessory gland substance) or male accessory gland fluid injected into virgin female Ae. aegypti affect female sexual refractoriness, blood feeding and digestion, flight, ovarian development, and oviposition. Using bioinformatic comparisons to Drosophila melanogaster accessory gland proteins and mass spectrometry of proteins from Ae. aegypti male accessory glands and ejaculatory ducts (AG/ED) and female reproductive tracts, we identified 63 new putative Ae. aegypti mRGPs. Twenty-one of these proteins were found in the reproductive tract of mated females, but not of virgin females, suggesting that they are transferred from males to females during mating. Most of the putative mRGPs fall into the same protein classes as mRGPs in other organisms, although some appear to be evolving rapidly and lack identifiable homologs in Culex pipiens, Anopheles gambiae, and D. melanogaster. Our results identify candidate male-derived molecules that may have an important influence on behavior, survival and reproduction of female mosquitoes.

show abstract

Evolution in the Fast Lane: Rapidly Evolving Sex-Related Genes in Drosophila

Cited by 356 publications

References 97 publications

Evolution of genes and genomes on the Drosophila phylogeny

Evolution of genes and genomes on the Drosophila phylogeny

Gene duplication, tissue-specific gene expression and sexual conflict in stalk-eyed flies (Diopsidae)

Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction

Contact Info

Product

Resources

About