Evolution of a phase separated gravity independent bioreactor

Villeneuve, Peter E.; Dunlop, Eric H.

doi:10.1016/0273-1177(92)90030-2

Cited by 9 publications

(2 citation statements)

References 6 publications

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“…Changing the gas and liquid phase (liquid now in the tubing) improved the oxygen transfer rate. According to their calculations, a 1 l bioreactor would be sufficient to recycle the carbon waste stream of ten astronauts (Villeneuve and Dunlop 1992). Two years later the group published their findings of the reactor operating in a parabolic flight with the conclusion that oxygen mass transfer and mixing are not affected by gravity (Villeneuve et al 1994).…”

Section: Mid-1980s-mid-1990s: Discovery and Characterization Of Cellumentioning

confidence: 99%

Fungal Biotechnology in Space: Why and How?

Cortesão

Schütze

Marx³

et al. 2020

Grand Challenges in Biology and Biotechnology

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Human space exploration is envisioning long-term spaceflight missions that go far beyond low Earth orbit (LEO). However, maintaining the necessary resources on a long-duration manned mission has its many challenges. Currently, on the International Space Station (ISS), astronauts are provided with resources in resupply missions. These missions transport all kinds of resources such as food, spacecraft materials, medical supplies or scientific experiments. The frequent exchange between Earth and spacecraft will not be possible for long-duration far-reaching missions, such as a 500-day human mission to Mars or the colonization of the Moon. Moreover, the cost per kilo calculated to be around $12,600 when launching a spacecraft (Harper et al. 2016) makes it impractical to bring all the needed supplies at once. The success of space exploration requires the ability to be Earthindependent, particularly when it comes to resources. The ideal scenario would be M. Cortesão

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Section: Mid-1980s-mid-1990s: Discovery and Characterization Of Cellumentioning

confidence: 99%

Fungal Biotechnology in Space: Why and How?

Cortesão

Schütze

Marx³

et al. 2020

Grand Challenges in Biology and Biotechnology

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“…The value of n depends on the flow regime, typically 0.5 for laminar flow and 0.8 for turbulent flow (Villeneuve and Eric, 1992) Re ¼ rv x;L d m and Sc ¼ m rD i;L ðA5Þ…”

Section: Appendixmentioning

confidence: 99%

Characterization of an experimental miniature bioreactor for cellular perturbation studies

Aboka

Jonge

Kerste

et al. 2006

Biotechnol. Bioeng.

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A mini bioreactor (3.0 mL volume) has been developed and shown to be a versatile tool for rapidly screening and quantifying the response of organisms on environmental perturbations. The mini bioreactor is essentially a plug flow device transformed into a wellmixed reactor by a recycle flow of the broth. The gas and liquid phases are separated by a silicone membrane. Dynamic mass transfer experiments were performed to determine the mass transfer capacities for oxygen and carbon dioxide. The mass transfer coefficients for oxygen and carbon dioxide were found to be 1.55 AE 0.17 Â 10 À5 m/ s and 4.52 AE 0.60 Â 10 À6 m/s, respectively. Cultivation experiments with the 3.0 mL bioreactor show that (i) it can maintain biomass in the same physiological state as the 4.0 L lab scale bioreactor, (ii) reproducible perturbation experiments such as changing substrate uptake rate can be readily performed and the physiological response monitored quantitatively in terms of the O 2 and CO 2 uptake and production rates. ß

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