The rapid process of urbanization has led to water pollution, reduction of space areas and channel deposition. However, current river protection and management levels are not suitable for city development level and human demand. Therefore, these problems have not yet been solved. China is still in an era of rapid urbanization, which means that the influence of urbanization in rivers will increase in the future—and the task of river protection and management will be more arduous. In order to meet the challenges and opportunities brought by urbanization and promote the sustainable use and management of river, this study puts forward relevant suggestions on river protection and management, such as river management mechanisms, economic incentive instruments, technical support, transformation of development concepts, improving laws, regulations and policies and stimulating public participation.