With reference to developed microfluidic systems, an experimental investigation is performed to define the effect of dissolved gases on the explosive evaporation of liquid in a confined microchamber. A stroboscopic imaging technique was used to visualize the stages of explosive evaporation. It was found that for liquids containing dissolved gases, a large, long-living gas bubble forms under the impulsively heated surface. During vapor cavity growth and collapse, the gas bubble is deformed and destroyed. Complicated bubble structures are formed. A gas bubble strongly damps the growth of the vapor cavity, which should be considered for design purposes.