1985
DOI: 10.1007/bf02115687
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Evolution of alu family repeats since the divergence of human and chimpanzee

Abstract: The DNA sequences of three members of the Alu family of repeated sequences located 5' to the chimpanzee alpha 2 gene have been determined. The base sequences of the three corresponding human Alu family repeats have been previously determined, permitting the comparison of identical Alu family members in human and chimpanzee. Here we compare the sequences of seven pairs of chimpanzee and human Alu repeats. In each case, with the exception of minor sequence differences, the identical Alu repeat is located at iden… Show more

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Cited by 66 publications
(26 citation statements)
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“…The seven Alu family sequences in the globin-gene region that have been compared between chimpanzee and human are in identical locations (37). It may be that there is selection against changes in sequence organization in the globin-gene region.…”
Section: Resultsmentioning
confidence: 99%
“…The seven Alu family sequences in the globin-gene region that have been compared between chimpanzee and human are in identical locations (37). It may be that there is selection against changes in sequence organization in the globin-gene region.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, detailed sequence analyses of Alu repeats mapping near human, chimpanzee, and orangutan globin genes show that Alu repeats are neither especially mobile nor subject to sequence conversion by putative master sequences (13,22,23). Of 400 sequenced Alu repeats in the data base, 3 (including the tissue plasminogen activator [TPA] Alu and Mlvi Alu used in this study) are polymorphic insertions into the human genome (7,8,29).…”
mentioning
confidence: 96%
“…A smear might be detected, reflecting high copy number and a ubiquitous distribution of SINE elements throughout the genome. Alternatively, if discrete bands were detected, limited variation might be expected as SINEs are thought to be stable once integrated into the genome (Sawada et al, 1985;Deininger 1989). Thus, the patterns detected should be consistent within a population except for occasional point mutations in restriction enzyme recognition sites.…”
Section: Introductionmentioning
confidence: 99%