Evolution of autobiographical memory impairments in Alzheimer's disease and frontotemporal dementia – A longitudinal neuroimaging study

Irish, Muireann; Landín-Romero, Ramón; Mothakunnel, Annu; Ramanan, Siddharth; Hsieh, Sharpley; Hodges, John R.; Piguet, Olivier

doi:10.1016/j.neuropsychologia.2017.03.014

Cited by 47 publications

(40 citation statements)

References 81 publications

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“…Autobiographical Interview data were re‐analysed from 51 participants who had taken part in a previous study on ABM (see Irish, Hornberger, et al ., ; Irish et al ., , ). Following the exclusion of one AD patient due to an unusually high score (94/100) on the Addenbrooke's Cognitive Examination‐Revised (ACE‐R; Mioshi, Dawson, Mitchell, Arnold, & Hodges, ), the final sample comprised 13 patients diagnosed with SD (Gorno‐Tempini et al ., ), 18 patients with clinically probable AD (McKhann et al ., ), and 20 healthy older Control participants.…”

Section: Methodsmentioning

confidence: 99%

“…This is not surprising given that internal details are proposed to connote rich episodic re-experiencing and yield diverse information relating to event happenings, time, place, sensory-perceptual, and emotional/thought contextual details (Levine et al, 2002). Further, the internal detail metric boasts impressive sensitivity to memory decline in healthy ageing (Schacter, Gaesser, & Addis, 2013) as well as across a wide range of clinical populations, such as major depressive disorder (Soderlund et al, 2014), medial temporal lobe epilepsy (St-Laurent, Moscovitch, Levine, & McAndrews, 2009), and neurodegenerative disorders including semantic dementia (SD; Irish, Hornberger, et al, 2011;Irish et al, 2014;McKinnon, Black, Miller, Moscovitch, & Levine, 2006), frontotemporal dementia (Irish, Hornberger, et al, 2011;Irish et al, 2014;McKinnon et al, 2008), and Alzheimer's disease (AD; Addis, Sacchetti, Ally, Budson, & Schacter, 2009;Irish et al, 2018). A consistent finding across clinical populations is a paucity of internal details, resulting in impoverished narratives of formerly evocative events.…”

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confidence: 99%

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External details revisited – A new taxonomy for coding ‘non‐episodic’ content during autobiographical memory retrieval

Strikwerda‐Brown

Mothakunnel

Hodges

et al. 2018

Journal of Neuropsychology

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Autobiographical memory (ABM) is typically held to comprise episodic and semantic elements, with the vast majority of studies to date focusing on profiles of episodic details in health and disease. In this context, 'non-episodic' elements are often considered to reflect semantic processing or are discounted from analyses entirely. Mounting evidence suggests that rather than reflecting one unitary entity, semantic autobiographical information may contain discrete subcomponents, which vary in their relative degree of semantic or episodic content. This study aimed to (1) review the existing literature to formally characterize the variability in analysis of 'non-episodic' content (i.e., external details) on the Autobiographical Interview and (2) use these findings to create a theoretically grounded framework for coding external details. Our review exposed discrepancies in the reporting and interpretation of external details across studies, reinforcing the need for a new, consistent approach. We validated our new external details scoring protocol (the 'NExt' taxonomy) in patients with Alzheimer's disease (n = 18) and semantic dementia (n = 13), and 20 healthy older Control participants and compared profiles of the NExt subcategories across groups and time periods. Our results revealed increased sensitivity of the NExt taxonomy in discriminating between ABM profiles of patient groups, when compared to traditionally used internal and external detail metrics. Further, remote and recent autobiographical memories displayed distinct compositions of the NExt detail types. This study is the first to provide a fine-grained and comprehensive taxonomy to parse external details into intuitive subcategories and to validate this protocol in neurodegenerative disorders.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

External details revisited – A new taxonomy for coding ‘non‐episodic’ content during autobiographical memory retrieval

Strikwerda‐Brown

Mothakunnel

Hodges

et al. 2018

Journal of Neuropsychology

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“…Only few studies reported no differences in memory retrieval across different lifetime epochs (e.g., Irish et al, 2011a), despite a poorer performance in comparison to healthy controls (Irish et al, 2014(Irish et al, , 2018. It is possible that this is due to methodological reasons.…”

Section: The Remote Self In Admentioning

confidence: 99%

The Petrified Self 10 Years After: Current Evidence for Mnemonic anosognosia

2020

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Lack of awareness about disease, its symptoms and consequences, also termed anosognosia, is a common feature of Alzheimer's disease (AD). It has been hypothesized that memory disorder may be a key contributing factor to anosognosia, with people with AD not being able to update their personal information about performance and relying on older consolidated material about ability. This potentially outdated sense of self has been named, as a metaphor, the petrified self. In the current review, evidence from the past 10 years in relation to this concept is critically appraised. In particular, focus is given to empirical evidence produced on anterograde memory deficits about performance, the profile of autobiographical retrograde memory loss and the role of frontal lobes in anosognosia in AD. Finally, wider consequences of this metaphor for the understanding of selfhood in dementia are discussed.

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“…circuits essential for the encoding, storage, and retrieval of information (Dickerson and Eichenbaum 2010). Mounting evidence, however, reveals episodic memory dysfunction across a range of dementia syndromes, including behavioral-variant frontotemporal dementia, semantic dementia, and logopenic progressive aphasia (McKinnon et al 2006;Irish et al 2011Irish et al , 2014bIrish et al , 2016Ramanan et al 2016), which becomes increasingly pronounced with disease evolution (Ramanan et al 2017;Irish et al 2018). Our findings indicate the presence of marked impairments exclusively for delayed recall in a distinct subgroup of patients with Corticobasal Syndrome, reflecting the breakdown of core nodes of the episodic memory network.…”

Section: Discussionmentioning

confidence: 69%

“…The posterior cingulate cortex further plays an important role in self-referential aspects of cognition (see Brewer et al 2013;Wong et al 2017), including the reinstatement and consolidation of episodic memories (Bird et al 2015). Early dysfunction of the posterior cingulate cortex reliably predicts the onset of neurodegenerative syndromes like AD (Minoshima et al 1997) as well as impairments across an array of putative episodic memory functions such as episodic retrieval (Irish et al 2014b), autobiographical memory (Irish et al 2018), scene construction and future thinking (Irish et al 2012(Irish et al , 2015 in this syndrome. As such, our findings confirm the importance of key regions within a posterior memory network (Gilmore et al 2015), centered on the hippocampus but including lateral and medial parietal regions, and suggest that degeneration of these regions manifests in stark episodic memory impairments irrespective of clinical phenotype.…”

Section: Discussionmentioning

confidence: 99%

Fronto-parietal contributions to episodic retrieval—evidence from neurodegenerative disorders

et al. 2019

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Converging evidence suggests a critical role for the parietal cortices in episodic memory retrieval. Here, we examined episodic memory performance in Corticobasal Syndrome (CBS), a rare neurodegenerative disorder presenting with early parietal atrophy in the context of variable medial temporal lobe damage. Forty-four CBS patients were contrasted with 29 typical Alzheimer's disease (AD), 29 healthy Controls, and 20 progressive supranuclear palsy patients presenting with brainstem atrophy as a disease control group. Participants completed standardized assessments of verbal episodic memory (learning, delayed recall, and recognition), and underwent structural and diffusion-weighted MRI. Selective delayed recall deficits were evident in the CBS group relative to Controls, at an intermediate level to the stark amnesia displayed by AD, and Control-level performance noted in progressive supranuclear palsy. Considerable variability within the CBS group on delayed recall performance led to the identification of memory-spared (N = 19) and memory-impaired (N = 25) subgroups. Whereas CBS-Spared showed no significant memory deficits, the CBS-Impaired subgroup were indistinguishable from typical AD across all episodic memory measures. Whole-brain voxel-based morphometry analyses implicated fronto-parietal and medial temporal regions in delayed recall performance in both the CBS-Impaired and AD groups. Furthermore, diffusion tensor imaging analyses revealed correlations between delayed recall performance and altered structural connectivity between fronto-parietal and frontotemporal regions in the CBS-Impaired group. Our findings underscore the importance of a distributed brain network including frontal, medial temporal, and parietal brain regions in supporting the capacity for successful episodic memory retrieval.

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Evolution of autobiographical memory impairments in Alzheimer's disease and frontotemporal dementia – A longitudinal neuroimaging study

Cited by 47 publications

References 81 publications

External details revisited – A new taxonomy for coding ‘non‐episodic’ content during autobiographical memory retrieval

External details revisited – A new taxonomy for coding ‘non‐episodic’ content during autobiographical memory retrieval

The Petrified Self 10 Years After: Current Evidence for Mnemonic anosognosia

Fronto-parietal contributions to episodic retrieval—evidence from neurodegenerative disorders

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