2011
DOI: 10.1053/j.semnuclmed.2010.12.001
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Evolution of Brain Imaging Instrumentation

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Cited by 48 publications
(23 citation statements)
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References 111 publications
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“…fMRI detects changes induced by cerebral blood flow (CBF) and/or oxygen consumption rate, accompanying modulations in neuronal activity on the regional deoxyhaemoglobin content, acting as an endogenous paramagnetic contrast agent. The information provided is similar to that obtained with FDG PET or radiolabelled water, at least under physiological conditions, whereby glucose metabolism and CBF are coupled [12]; fMRI has replaced PET for activation studies, because of the lack of ionizing radiations and a much greater temporal and spatial resolution. With a leading place in cognitive psychophysiology to investigate local neuronal activation, fMRI may be used to discover networks of activation associated with a variety of pathologies.…”
Section: Functional Mrimentioning
confidence: 58%
“…fMRI detects changes induced by cerebral blood flow (CBF) and/or oxygen consumption rate, accompanying modulations in neuronal activity on the regional deoxyhaemoglobin content, acting as an endogenous paramagnetic contrast agent. The information provided is similar to that obtained with FDG PET or radiolabelled water, at least under physiological conditions, whereby glucose metabolism and CBF are coupled [12]; fMRI has replaced PET for activation studies, because of the lack of ionizing radiations and a much greater temporal and spatial resolution. With a leading place in cognitive psychophysiology to investigate local neuronal activation, fMRI may be used to discover networks of activation associated with a variety of pathologies.…”
Section: Functional Mrimentioning
confidence: 58%
“…The integrity of the of BBB has been assessed radio-graphically for decades initially using radionuclide brain scans and more recently using computed tomography (CT) and magnetic resonance (MR) imaging [2022]. The basic principle underlying these studies are that water soluble agents with a molecular weight greater than ≥160 D do not pass through an intact BBB but do enter regions of the brain where the BBB is disrupted [23, 24].…”
Section: Introductionmentioning
confidence: 99%
“…This technique is known to be less sensitive for smaller lesions or less disrupted areas [2527]. CT has been shown to be more sensitive than SPECT in detecting smaller areas of BBB disruption because SPECT results in low spatial resolution [22]. …”
Section: Introductionmentioning
confidence: 99%
“…Subsequently, PET has superior signal to noise ratio because of the technology capitalizing on PET tracers' innate radioactive decay properties. 244,245 However, some of the benefits brain SPECT has over brain PET include flexibility in use (no need for nearby cyclotron or radiotracer distributer), radiotracer with longer half-lives (greater flexibility for functional images and for delayed imaging). Generator-acquired brain PET agents such as Gallium-68, which do not require a nearby cyclotron, are being used in brain malignancy research but have no currently published reports with regard to TBI imaging.…”
Section: Single Photon Emission Computed Tomographymentioning
confidence: 99%