Evolution of catalytic antibody repertoire in autoimmune mice

Nishi, Yoshisuke

doi:10.1016/s0022-1759(02)00233-8

Cited by 38 publications

(26 citation statements)

References 99 publications

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“…The inability of some patients to express higher levels of catalytic antibodies may be related to the genetic polymorphism of the repertoire of Ig variable region-encoding genes that characterizes the human population. This finding is reminiscent of findings in BALB͞c and MRL͞lpr mice, that have different abilities to produce catalytic antibodies and that use different V genes, after immunization with phosphonate haptens (31,32). Alternatively, lower levels of IgG-mediated hydrolysis may relate to an increased prevalence of anti-idiotypic antibodies that neutralize autologous IgG catalysts.…”

Section: Discussionmentioning

confidence: 68%

High levels of catalytic antibodies correlate with favorable outcome in sepsis

Lacroix‐Desmazes

Bayry

Kaveri

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

110

102

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Sepsis is the leading cause of death in intensive care units and results from a deleterious systemic host response to infection. Although initially perceived as potentially deleterious, catalytic antibodies have been proposed to participate in removal of metabolic wastes and protection against infection. Here we show that the presence in plasma of IgG endowed with serine protease-like hydrolytic activity strongly correlates with survival from sepsis. Variances of catalytic rates of IgG were greater in the case of patients with severe sepsis than healthy donors (P < 0.001), indicating that sepsis is associated with alterations in plasma levels of hydrolytic IgG. The catalytic rates of IgG from patients who survived were significantly greater than those of IgG from deceased patients (P < 0.05). The cumulative rate of survival was higher among patients exhibiting high rates of IgG-mediated hydrolysis as compared with patients with low hydrolytic rates (P < 0.05). An inverse correlation was also observed between the markers of severity of disseminated intravascular coagulation and rates of hydrolysis of patients' IgG. Furthermore, IgG from three surviving patients hydrolyzed factor VIII, one of which also hydrolyzed factor IX, suggesting that, in some patients, catalytic IgG may participate in the control of disseminated microvascular thrombosis. Our observations provide the first evidence that hydrolytic antibodies might play a role in recovery from a disease.

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Section: Discussionmentioning

confidence: 68%

High levels of catalytic antibodies correlate with favorable outcome in sepsis

Lacroix‐Desmazes

Bayry

Kaveri

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

110

102

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“…First, immunization of autoimmune mice leads to a dramatically higher incidence of Abzs with a higher activity comparing to conventionally used normal mouse strains [51,52]. The immune response to RNA and DNA and their complexes with histones and other proteins only partially depends on the length and sequence of nucleic acid [123,124].…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, immunization of mice with complex of DNA and histones or positively charged methylated bovine albumin, simulating positively charged histones, results in production of anti-DNA Abs and DNase abzymes with high activity [29-31, 49, 50]. It was shown that abzymes with different activities may be obtained with a significantly higher incidence in autoimmune mouse strains comparing to conventionally used control nonautoimmune mice [51,52]. Immunization of autoimmune-prone MRL-lpr/lpr mice with DNA-protein complexes also results in significantly higher production of anti-DNA Abs and abzymes with DNase activity comparing with nonautoimmune CBA and BALB/c healthy mice [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Catalytic Antibodies in Norm and Systemic Lupus Erythematosus

Nevinsky¹

2017

Lupus

321

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Systemic lupus erythematosus (SLE) is known as a systemic polyethiologic diffuse autoimmune disease characterized by connective tissue disorganization and the paramount damage of skin and visceral capillaries. Usually, SLE symptoms include high fever, hair loss, mouth ulcers, chest pain, swollen lymph nodes, painful and swollen joints, increased fatigue, and appearance of red rash more often on the face. The exact reason of SLE appearance is not really clear. Detection of catalytic Abs (abzymes) was shown to be the earliest indicator of different AI disease development. Some abzymes are cytotoxic and can play a dangerous negative role in the pathogenesis of AI diseases. SLE is characterized by the appearance of abzymes with several different catalytic functions including hydrolysis of peptides and proteins, DNA, RNA, and oligosaccharides. In addition, monoclonal SLE abzymes are characterized by extraordinary diversity in the affinity to the substrates, physicochemical and catalytic characteristics, optimal conditions of catalysis, cytotoxicity, etc. Production of abzymes in SLE mice is associated with changes in the differentiation of hematopoietic stem cells of bone marrow, increase in lymphocyte proliferation, and significant suppression of cell apoptosis in different organs. In this chapter, abzymes with different catalytic activities in SLE are described.

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“…Some healthy humans produce Abzs with low VIP- (Paul et al, 1989), and thyroglobulin-hydrolyzing activities , but usually healthy volunteers and patients with many diseases with insignificant autoimmune reactions lack Abzs with proteolytic activity , and refs therein). Since immunization of AI mice results in a dramatically higher incidence of Abzs with a higher activity than in conventionally used normal mouse strains (Tawfik et al, 2002;Nishi, 2002), the formation of Abzs in AI and some viral diseases may be much more profuse. The question is why autoimmunization of AI patients and mice results in a dramatically higher incidence of catalytically inactive Abs and Abzs with enzyme properties as compared with healthy humans and animals.…”

Section: The Origin Of Artificial and Natural Abzymesmentioning

confidence: 99%

“…In addition, AI reactions in the case of some viral diseases including AIDS patients are in some extent similar to AI diseases. At the same time, immunization of AI mice produces an unexpectedly high increase in the number of clones secreting various auto-Abs, including Abzs, in comparison with normal mice (Nishi, 2002;Tawfik et al, 2002). HIV-1 RT-and IN-hydrolzying pIgGs and IgMs from HIV-infected patients were the first examples of catalytic Abzs produced in humans against viral proteins after a viral infection (Odintsova et al, 2006 b ;Baranova et al, 2009Baranova et al, , 2010.…”

Section: Comparison Of the Relative Catalytic Activity Of Abs From DImentioning

confidence: 99%

Natural Catalytic Antibodies in Norm and in HIV-Infected Patients

Nevinsky¹

2011

Understanding HIV/AIDS Management and Care - Pandemic Approaches in the 21st Century

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Evolution of catalytic antibody repertoire in autoimmune mice

Cited by 38 publications

References 99 publications

High levels of catalytic antibodies correlate with favorable outcome in sepsis

High levels of catalytic antibodies correlate with favorable outcome in sepsis

Catalytic Antibodies in Norm and Systemic Lupus Erythematosus

Natural Catalytic Antibodies in Norm and in HIV-Infected Patients

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