This research delves into the critical domain of Tomato Leaf Disease classification using advanced machine learning techniques. Specifically, a comparative evaluation was conducted between a Base CNN model devoid of ResNet-50 integration and a Proposed Method harnessing the capabilities of ResNet-50. The results elucidated a notable enhancement in performance metrics when leveraging ResNet-50, with the Proposed Method consistently achieving exceptional accuracy scores of 99.96%, 99.98%, and 99.96% across data splits of 90:10, 80:20, and 70:30, respectively. Furthermore, the ResNet-50 integration significantly augmented key metrics, including recall, precision, and F1-Score, thereby accentuating its pivotal role in enhancing sensitivity and positive predictive value for tomato leaf disease classification. As for prospective research trajectories, this study highlights potential avenues for refinement, encompassing the exploration of ensemble techniques amalgamating diverse architectural frameworks, advanced data augmentation methodologies, and broader disease classification scopes. Collectively, this research underscores the transformative potential of ResNet-50 in agricultural diagnostics, advocating for continued exploration and innovation to fortify global food security and sustainable farming practices. Future research could explore ensemble techniques, advanced data augmentation, broader disease classification scopes, and interdisciplinary collaborations to develop comprehensive diagnostic tools for sustainable farming practices and global food security.