Blocking also affects TRs which do not bind DNA but regulate other TFs by direct interaction, as is the case of JASMONATE ZIM-DOMAIN (JAZ) proteins that mediate jasmonic acid (JA) signalling, restricting their capacity to regulate other proteins (Hou et al. 2010;. Negative regulation by sequestering their partners is one of the most commonly described mechanisms of DELLA function. Furthermore, DELLAs are also able to interact with subunits of different regulatory complexes to block or dampen their functions, such as with the PICKLE ATPase,