Evolution of drug-eluting biomedical implants for sustained drug delivery

Quarterman, Juliana C.; Geary, Sean M.; Salem, Aliasger K.

doi:10.1016/j.ejpb.2020.12.005

Cited by 60 publications

(37 citation statements)

References 171 publications

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“…Polymer coatings on implants and other biomedical devices are frequently used as local drug delivery systems, which allows for in situ release in the immediate targeted tissue, optimizing the therapeutic effects. Medications can be released at controlled rates in the range of effective treatment levels, increasing their bioavailability [1]. In this sense, mathematical modeling of drug delivery and release predictability is useful in development and understanding of drug release mechanisms from controlled delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modeling of Recursive Drug Delivery with Diffusion, Equilibrium, and Convection Coupling

et al. 2022

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In this work, a mathematical model to describe drug delivery from polymer coatings on implants is proposed. Release predictability is useful for development and understanding of drug release mechanisms from controlled delivery systems. The proposed model considers a unidirectional recursive diffusion process which follows Fick’s second law while considering the convective phenomena from the polymer matrix to the liquid where the drug is delivered and the polymer–liquid drug distribution equilibrium. The resulting model is solved using Laplace transformation for two scenarios: (1) a constant initial condition for a single drug delivery experiment; and (2) a recursive delivery process where the liquid medium is replaced with fresh liquid after a fixed period of time, causing a stepped delivery rate. Finally, the proposed model is validated with experimental data.

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Section: Introductionmentioning

confidence: 99%

Mathematical Modeling of Recursive Drug Delivery with Diffusion, Equilibrium, and Convection Coupling

et al. 2022

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“…Mechanical reperfusion with stent implantation is a life-saving operation for patients with acute infarction. The first implants, bare metal stents, were highly effective but caused in-stent restenosis after 6–12 months [ 15 ]. This complication is defined by the organization of fibrin surrounding the stent followed by neointimal proliferation.…”

Section: Iddss and Fbr: Current Clinical Landscapementioning

confidence: 99%

“…Bishop reported the first clinical use of IDDS for hormonal therapy in women [ 13 , 14 ]. Then, a few more implantable drug formulations were briefly studied [ 15 ]. Technologically, the era of the modern IDDS started in 1960s [ 9 ], when Folkman and Long demonstrated the application of a capsular (reservoir-type) device comprising a silicone rubber “Silastic” together with a semipermeable membrane, which used as a carrier for prolonged drug delivery to the ventricular myocardium in dogs with modeled heart block [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…The clinical expansion of IDDSs was launched in the 1990s after the levonorgestrel-containing contraceptive implant Norplant ® , based on Folkman’s and Long’s “Silastic” capsule schematics, obtained Food and Drug Administration (FDA) approval [ 15 ]. Currently, commercially available IDDSs are applied for the treatment of chronic diseases, pregnancy control and women’s health, pain management and mental health, and guided regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…(e.g., dominated by either passive diffusion, supported by artificial osmotic gradients, or enhanced by mechanically , thermally , magnetically , etc.–activated convection). The diversity of IDDSs, including the material, engineering, and drug release features, is comprehensively reviewed elsewhere [ 7 , 9 , 12 , 14 , 15 , 18 , 19 , 20 ]. For the purposes of this review, the most important categories are the anatomical placement of the IDDS, whether it has to be removed from the body after some time, and whether and to what extent it is biodegradable or bioerodible.…”

Section: Introductionmentioning

confidence: 99%

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Implantable Drug Delivery Systems and Foreign Body Reaction: Traversing the Current Clinical Landscape

et al. 2021

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Precise delivery of therapeutics to the target structures is essential for treatment efficiency and safety. Drug administration via conventional routes requires overcoming multiple transport barriers to achieve and maintain the local drug concentration and commonly results in unwanted off-target effects. Patients’ compliance with the treatment schedule remains another challenge. Implantable drug delivery systems (IDDSs) provide a way to solve these problems. IDDSs are bioengineering devices surgically placed inside the patient’s tissues to avoid first-pass metabolism and reduce the systemic toxicity of the drug by eluting the therapeutic payload in the vicinity of the target tissues. IDDSs present an impressive example of successful translation of the research and engineering findings to the patient’s bedside. It is envisaged that the IDDS technologies will grow exponentially in the coming years. However, to pave the way for this progress, it is essential to learn lessons from the past and present of IDDSs clinical applications. The efficiency and safety of the drug-eluting implants depend on the interactions between the device and the hosting tissues. In this review, we address this need and analyze the clinical landscape of the FDA-approved IDDSs applications in the context of the foreign body reaction, a key aspect of implant–tissue integration.

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