Evolution of empiric vancomycin dosing in a neonatal population

An Audit to Evaluate Vancomycin Therapeutic Drug Monitoring in a Neonatal Intensive Care Unit

“…Our dosing protocol of 15 mg/kg per dose was effective in achieving initial target trough concentrations and it resembles a dose regimen used in a study by Anaïs et al, which used a lower dose of 10 mg/kg per dose. 27 Radu et al 28 also used a 15 mg/kg per dose protocol, similar to that in our study. In both studies, target attainment was achieved in more than 50% of the participants.…”

“…They found that the youngest group required the highest mean dose increase (9 patients, 50.4%), whereas the eldest group required an average dose reduction (4 patients, −26.6%). 28 The TDM protocol included a large dose increase (>50%), in case levels were <5 mg/L; this could potentially result in a supratherapeutic concentration, if the adjustment is made before steady state. Fortunately, we did not find any of such cases in our study; however, the sample size in this patient category was also small (n = 10 courses).…”