Evolution of endoscopic resection for early esophageal squamous cell carcinoma in Western countries

Isomoto, Hajime

doi:10.1055/a-0790-8472

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Esophagectomy, a standard procedure for EC, has now been replaced by endoscopic submucosal dissection (ESD) for esophageal squamous cell neoplasia. ESD results in greater en bloc resection and is associated with shorter hospital stays and lower local recurrence rates, costs, and incidence of adverse events 6 , 7 . However, ESD is technically demanding and restricted to EC cases with a submucosal invasion < 200 µm, short segment (< 3 cm), and luminal circumferential lesion < 50%.…”

Section: Introductionmentioning

confidence: 99%

Assessment of efficacy and safety of advanced endoscopic irreversible electroporation catheter in the esophagus

Jeon

Choi

Lee

et al. 2023

Sci Rep

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Nonthermal irreversible electroporation (NTIRE) is emerging as a promising tissue ablation technique. However, maintaining irreversible electroporation (IRE) electrodes against displacement during strong esophageal spasms remains an obstacle. The present study aimed to evaluate the efficacy and safety of newly designed balloon-type endoscopic IRE catheters. Six pigs were randomly allocated to each catheter group, and each pig was subjected to four ablations at alternating voltages of 1500 V and 2000 V. Esophagogastroscopy was performed during the IRE. The ability of balloon-type catheters to execute complete IRE with 40 pulses was assessed. The success rate was higher for the balloon-type catheter than that for the basket-type (12/12 [100%] vs. 2/12 [16.7%], p < 0.001). Following gross inspection and histologic analysis of the 1500-V vs. 2000-V balloon-type catheter revealed a larger mucosal damage area (105.3 mm2 vs. 140.8 mm2, p = 0.004) and greater damage depth (476 μm vs. 900 μm, p = 0.02). Histopathology of the ablated tissue revealed separated epithelium, inflamed lamina propria, congested muscularis mucosa, necrotized submucosa, and disorganized muscularis propria. Balloon-type catheters demonstrated efficacy, achieving full electrical pulse sequences under NTIRE conditions, and a safe histological profile below 2000 V (1274 V/cm). Optimal electrical conditions and electrode arrays pose ongoing challenges.

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Section: Introductionmentioning

confidence: 99%

Assessment of efficacy and safety of advanced endoscopic irreversible electroporation catheter in the esophagus

Jeon

Choi

Lee

et al. 2023

Sci Rep

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Conventional versus traction-assisted endoscopic submucosal dissection for large esophageal cancers: a multicenter, randomized controlled trial (with video)

Yoshida

Takizawa

Nonaka

et al. 2020

Gastrointestinal Endoscopy

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Novel guidewire-assisted over-the-wire balloon-type versus through-the-scope basket-type endoscopic irreversible electroporation catheter for ablation in the esophagus: an experimental study

Jeon

Choi

Lee

et al. 2022

Preprint

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Non-thermal irreversible electroporation (NTIRE) is emerging as a promising tissue ablation technique. However, maintaining irreversible electroporation (IRE) electrodes against displacement from the forces of strong esophageal spasms remains an obstacle. Therefore, the present study evaluates the efficacy and safety of newly designed balloon-type endoscopic IRE catheters. Six pigs were randomly allocated to each catheter group, and four ablations were performed on each at alternating voltages (1500 and 2000 V). Esophagogastroscopy was performed during IRE. The ability of balloon-type catheters to deliver full NTIRE sequences was assessed, followed by a histopathologic analysis. The success rate was higher for the balloon- than basket-type catheter (12/12 [100%] vs. 2/12 [16.7%], p < 0.001). Gross inspection and histologic analysis of the 2000-V vs. 1000-V balloon-type catheter revealed a larger mucosal damage area (105.3 mm2 vs. 140.8 mm2, p = 0.004) and deeper damage depth (476 μm vs. 900 μm, p = 0.02). Histopathology of the ablated tissue revealed a separated epithelium, inflamed lamina propria, congested muscularis mucosa, necrotized submucosa, and disorganized muscularis propria. Balloon-type catheters demonstrated remarkable efficacy, achieving full electrical pulse sequences under NTIRE conditions and a safe histological profile below 2000 V (1274 V/cm).

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Evolution of endoscopic resection for early esophageal squamous cell carcinoma in Western countries

Cited by 3 publications

References 8 publications

Assessment of efficacy and safety of advanced endoscopic irreversible electroporation catheter in the esophagus

Assessment of efficacy and safety of advanced endoscopic irreversible electroporation catheter in the esophagus

Conventional versus traction-assisted endoscopic submucosal dissection for large esophageal cancers: a multicenter, randomized controlled trial (with video)

Novel guidewire-assisted over-the-wire balloon-type versus through-the-scope basket-type endoscopic irreversible electroporation catheter for ablation in the esophagus: an experimental study

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