Evolution of exon 1 of the dopamine D4 receptor (DRD4) gene in primates

Seaman, Michael I.; Chang, Feng-Cheng; Deinard, Amos S.; Quiñones, Ana T.; Kídd, Kenneth K.

doi:10.1002/(sici)1097-010x(20000415)288:1<32::aid-jez4>3.0.co;2-g

Cited by 18 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MAOA : Inoue-Murayama et al 2006) or risk-seeking behaviour (e.g. DRD4 : Seaman et al 2000; Eisenberg et al 2008) may indicate a genetic explanation for differences in hunting and patrolling behaviour. Additionally, more detailed analyses of within-individual variation in patrolling and hunting effort are needed.…”

Section: Discussionmentioning

confidence: 99%

Ecology rather than psychology explains co-occurrence of predation and border patrols in male chimpanzees

2013

View full text Add to dashboard Cite

The intense arousal and excitement shown by adult male chimpanzees, Pan troglodytes, during territorial attacks on other chimpanzees and predation upon monkeys suggest that similar psychological mechanisms may be involved. Specifically, it has been proposed that hunting behaviour in chimpanzees evolved from intraspecies aggression. Over 32 years, chimpanzees at Gombe National Park, Tanzania were significantly more likely to engage in a territorial border patrol on days when they hunted red colobus monkeys (Procolobus spp.), and vice versa, even after statistically controlling for male chimpanzee party size. We test the hypothesis that this correlation arises because hunting and patrolling are components of a specieslevel aggressive behavioural syndrome; specifically that predation arose as a by-product of territorial aggression in this species. However, hunting was equally likely to occur after a patrol and/or an intergroup interaction as it was before, and the occurrence of an intergroup interaction in which the chimpanzees approached strangers did not increase subsequent hunting probability. We also reject the hypothesis that hunting and patrolling reflect an individual-level behavioural syndrome. We identified two ‘impact hunters’ whose presence increased hunting probability. Similarly, there were also three ‘impact patrollers’, who increased the likelihood that a visit to the periphery of the community range resulted in a patrol. While this discovery has important implications for our understanding of the proximate causes of cooperation, it does not explain the temporal correlation between patrolling and hunting, since no males had such an impact in both contexts. Instead, the data suggest that the correlation arose because patrols typically involved males travelling long distances, which increased the probability of encountering prey. Additionally, parties that travelled to the periphery were more likely to encounter colobus in woodland, where hunts are more likely to occur and to succeed. Therefore, we conclude that ecological, rather than psychological, factors promote the co-occurrence of hunting and territorial aggression in this species.

show abstract

Section: Discussionmentioning

confidence: 99%

Ecology rather than psychology explains co-occurrence of predation and border patrols in male chimpanzees

2013

View full text Add to dashboard Cite

show abstract

“…The genetic base of personality has been confirmed by establishing a significant heritability of numerous traits (Bouchard and Loehlin 2001). Polymorphisms in the DRD4 and 5-HTT genes have also been identified in some animals, including nonhuman primates (Livak et al 1995;Seaman et al 2000;Inoue-Murayama et al 2008), and they may influence their personality traits much as in humans Spinelli et al 2007;. Several other neuropeptides and hormones have been connected to personality, including testosterone (androgen receptor polymorphism: Westberg et al 2009;circulating testosterone: Rowe et al 2004), vasopressin (Bartz andHollander 2006), and cortisol (Hauner et al 2008).…”

Section: Finding Common Groundmentioning

confidence: 99%

From Genes to Animal Behavior

Inoue‐Murayama¹,

Kawamura²,

Weiß³

2011

Primatology Monographs

View full text Add to dashboard Cite

Association of dopamine D4 receptor (DRD4) polymorphisms with attention deficit hyperactivity disorder in Indian population

Bhaduri

Das

Sinha

et al. 2005

American J of Med Genetics Pt B

View full text Add to dashboard Cite

Attention deficit hyperactivity disorder (ADHD) is a childhood onset neurobehavioral disorder. Several studies worldwide have implicated a possible association between ADHD and transmission of different polymorphisms of the dopamine D4 receptor gene (DRD4) in different ethnic groups. However, this is the first report on the transmission of different polymorphisms of DRD4 in Indian subjects. Association of 5' flanking 120-bp duplication, exon 1 12-bp duplication, and exon 3 48-bp variable numbers of tandem repeats (VNTR) were analyzed in 50 ADHD cases. Haplotype-based haplotype relative risk (HHRR) analysis and transmission disequilibrium test (TDT) were carried out to ascertain the association of these polymorphisms with the disorder. Linkage disequilibria (LD) between the polymorphisms were calculated using EH+ and 2LD programs. Our preliminary data showed lack of association between ADHD and transmission of the 5' flanking 120-bp duplication and exon 1 12-bp duplication. But, the transmissions of 6 and 7 repeat alleles of exon 3 48-bp VNTR showed significant association with ADHD. We have also examined the haplotype frequencies and biased transmission of one haplotype was observed in ADHD probands. LD analysis showed very strong disequilibrium between exon 1 12-bp duplication and exon 3 48-bp VNTR. Strong LD was also observed between the 5' flanking 120-bp duplication and exon 1 12-bp duplication. The observed association between higher repeat alleles of exon 3 48-bp VNTR and Indian ADHD children is consistent with some of the earlier reports.

show abstract

Evolution of exon 1 of the dopamine D4 receptor (DRD4) gene in primates

Cited by 18 publications

References 29 publications

Ecology rather than psychology explains co-occurrence of predation and border patrols in male chimpanzees

Ecology rather than psychology explains co-occurrence of predation and border patrols in male chimpanzees

From Genes to Animal Behavior

Association of dopamine D4 receptor (DRD4) polymorphisms with attention deficit hyperactivity disorder in Indian population

Contact Info

Product

Resources

About