Evolution of fetal ventricular dilatation in relation to severity at first presentation

Lam, Sarah-Jane; Kumar, Sailesh

doi:10.1002/jcu.22124

Cited by 14 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have associated fetal ventriculomegaly with chromosomal abnormalities, especially trisomy 21. The rate of chromosomal abnormalities among cases of fetal ventriculomegaly ranges from 4 to 14% (4,(13)(14)(15). In our study, 57 cases underwent karyotype examination, and 5 cases were abnormal (8.7%), similar to Chiu et al's (16) finding of 9.8%.…”

Section: Discussionsupporting

confidence: 86%

Fetal ventriculomegaly: Pregnancy outcomes and follow-ups in ten years

Chu

Zhang

Yan

et al. 2016

BST

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 86%

Fetal ventriculomegaly: Pregnancy outcomes and follow-ups in ten years

Chu

Zhang

Yan

et al. 2016

BST

View full text Add to dashboard Cite

“…Isolated mild unilateral ventriculomegaly, for example, has been shown to normalize after birth in 40% of clinical referrals. 27,28 Similarly, prenatal isolated mild vermis hypoplasia has been shown to normalize in 32% by the time of postnatal MR imaging evaluation. 29 Together these findings call for extra caution when interpreting mild prenatal brain findings of unknown etiology on conventional MR imaging because a high proportion of these subtle markers of delayed brain development may normalize by the end of the pregnancy.…”

Section: Discussionmentioning

confidence: 98%

Brain Injury in Neonates with Complex Congenital Heart Disease: What Is the Predictive Value of MRI in the Fetal Period?

Brossard‐Racine

Plessis²,

Vézina³

et al. 2016

American Journal of Neuroradiology

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE Brain injury in neonates with congenital heart disease is an important predictor of adverse neurodevelopmental outcome. Impaired brain development in congenital heart disease may have a prenatal origin, but the sensitivity and specificity of fetal brain MR imaging for predicting neonatal brain lesions are currently unknown. We sought to determine the value of conventional fetal MR imaging for predicting abnormal findings on neonatal preoperative MR imaging in neonates with complex congenital heart disease. MATERIALS AND METHODS MR imaging studies were performed in 103 fetuses with confirmed congenital heart disease (mean gestational age, 31.57 ± 3.86 weeks) and were repeated postnatally before cardiac surgery (mean age, 6.8 ± 12.2 days). Each MR imaging study was read by a pediatric neuroradiologist. RESULTS Brain abnormalities were detected in 17/103 (16%) fetuses by fetal MR imaging and in 33/103 (32%) neonates by neonatal MR imaging. Only 9/33 studies with abnormal neonatal findings were preceded by abnormal findings on fetal MR imaging. The sensitivity and specificity of conventional fetal brain MR imaging for predicting neonatal brain abnormalities were 27% and 89%, respectively. CONCLUSIONS Brain abnormalities detected by in utero MR imaging in fetuses with congenital heart disease are associated with higher risk of postnatal preoperative brain injury. However, a substantial proportion of anomalies on postnatal MR imaging were not present on fetal MR imaging; this result is likely due to the limitations of conventional fetal MR imaging and the emergence of new lesions that occurred after the fetal studies. Postnatal brain MR imaging studies are needed to confirm the presence of injury before open heart surgery.

show abstract

“…Severe VM is defined by measurement of the posterior horns of the lateral ventricles at or above 15 mm. This is reported to be suggestive of major brain abnormalities, associated with a high likelihood of progression of the ventricular enlargement and coexistence of additional CNS structural abnormalities [3]. In the largest reported case series of antenatally diagnosed severe VM, approximately 45 % had additional abnormalities [4] with higher proportions reported in other cohorts [3,5,6].…”

Section: Introductionmentioning

confidence: 92%