Evolution of Gas Permeable Membranes for Extracorporeal Membrane Oxygenation

Yeager, Torin; Roy, Shuvo

doi:10.1111/aor.12835

Cited by 80 publications

(49 citation statements)

References 55 publications

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“…Flat sheet membranes separated by separating screens were used in the first membrane oxygenators for the provision of the flow of gas and blood ( Fig. 1) followed by their assembly into a flat-parallel structure like, e.g., in a Travenol oxygenator [4], or in the form of a spiral-wound-type apparatus like in a cylindrical Kolobov oxygenator [4].…”

Section: Nonporous (Diffusion) Polymermentioning

confidence: 99%

“…The oxygenator developed by Gibbon belonged to devices of the stationary film type and was a set of six to eight wire screens with a length of 60 cm and a width of 10 cm vertically placed into a plastic container, in which blood flew from top to bottom, thus forming a stable blood film contacting with oxygen [2]. The second variety of film-type oxygenators was represented by rotating oxygenators, in which a large area of the contact of blood with the gas was achieved due to the rotation of the moving parts, cylinders [3] or disks [4]. One of the main disadvantages of film-type oxygenators were their bulkiness resulting from the requirement of providing an acceptable area of the contact of blood and the gas phase and time-consuming and complex maintenance.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, prolonged extracorporeal perfusion could lead to the deterioration of peripheral perfusion, acidosis, and progressive organ failure [2]. The application of bubble oxygenators was also associated with a risk of gaseous embolism [4].…”

Section: Introductionmentioning

confidence: 99%

“…The main disadvantages of direct-contact oxygenators associated with a short duration of operation and a high risk of development of complications were overcome with the introduction of membrane-type oxygenators [4], in which the blood is separated from the gas phase by a semipermeable membrane and the gaseous exchange is executed in the process of diffusion of gases through the membrane, into clinical practice. The modern extracorporeal membrane oxygenation technology (ECMO) is aimed not only at saving a patient in a critical state during surgical interventions but is also intended for patients with potentially invertible disorders of cardiovascular and/or respiratory systems, the treatment of which using standard therapy is ineffective [7].…”

Section: Introductionmentioning

confidence: 99%

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Membranes in Extracorporeal Blood Oxygenation Technology

Евсеев

Журавель

Alentiev

et al. 2019

Membr. Membr. Technol.

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The development and implementation of the extracorporeal membrane oxygenation (ECMO) technique for the treatment of patients in critical conditions make it possible to effectively and safely support gas exchange processes in the blood for a long time. One of the main components of the ECMO unit is a gas permeable membrane which is a barrier separating the blood from the gas phase. Since the 1950s, the development of this technology has been aimed at improving the safety and duration of use of membranes, which led to the creation of oxygenators that provide life support for several weeks. This review is devoted to the development of the extracorporeal membrane oxygenation technology including the choice of materials, methods to improve their hemocompatibility, and approaches to the design of the membrane contactor.

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Section: Nonporous (Diffusion) Polymermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Membranes in Extracorporeal Blood Oxygenation Technology

Евсеев

Журавель

Alentiev

et al. 2019

Membr. Membr. Technol.

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“…Yeager and Roy of the University of California, San Francisco, CA, USA reviewed the evolution of gas permeable membranes for ECMO. Over more than half a century, membrane fabrication and packaging technology have progressed to enable safer and longer duration use of respiratory life support.…”

Section: Pulmonary Supportmentioning

confidence: 99%

Artificial Organs 2017: A Year in Review

Malchesky¹

2018

Artificial Organs

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In this Editor's Review, articles published in 2017 are organized by category and summarized. We provide a brief reflection of the research and progress in artificial organs intended to advance and better human life while providing insight for continued application of these technologies and methods. Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level." Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. Peer-reviewed Special Issues this year included contributions from the 12th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion edited by Dr. Akif Undar, Artificial Oxygen Carriers edited by Drs. Akira Kawaguchi and Jan Simoni, the 24th Congress of the International Society for Mechanical Circulatory Support edited by Dr. Toru Masuzawa, Challenges in the Field of Biomedical Devices: A Multidisciplinary Perspective edited by Dr. Vincenzo Piemonte and colleagues and Functional Electrical Stimulation edited by Dr. Winfried Mayr and colleagues. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide meaningful suggestions to the author's work whether eventually accepted or rejected. Without these excellent and dedicated reviewers the quality expected from such a journal could not be possible. We also express our special thanks to our Publisher, John Wiley & Sons for their expert attention and support in the production and marketing of Artificial Organs. We look forward to reporting further advances in the coming years.

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Miniaturization of Artificial Lungs toward Portability

Dabaghi

Rochow

Saraei

et al. 2020

Adv Materials Technologies

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Artificial lungs support patients undergoing open‐heart surgery, organ transplantation, and in serious lung injury by providing oxygenation support through an extracorporeal circuit. Some patients require partial support for durations of a few weeks or months even after the surgery. Therefore, a portable or wearable lung assist device which can be operated for several weeks with minimum maintenance would be ideal. Miniaturization of blood oxygenators, using microfluidic technology, is a promising avenue for the realization of such portable artificial lungs. The microfluidic blood oxygenators (MBOs) are also suitable for neonates with respiratory failure due to their low priming volume and pressure drop. Herein, the history of microfluidic oxygenator development and recent progress in miniaturized artificial lungs are discussed. The MBOs have made significant advances in 1) reducing device size, 2) providing biomimetic blood flow paths, 3) enabling operation in room air, and 4) operating without the need of an external pump. Recent work has demonstrated throughput of up to 150 mL min‐1 of blood and oxygen transfer rate of 60 mL O2 per L of blood. The challenges faced by this technology in practical applications as well as future improvements to meet the requirements for older neonates and even adults are also presented.

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Evolution of Gas Permeable Membranes for Extracorporeal Membrane Oxygenation

Cited by 80 publications

References 55 publications

Membranes in Extracorporeal Blood Oxygenation Technology

Membranes in Extracorporeal Blood Oxygenation Technology

Artificial Organs 2017: A Year in Review

Miniaturization of Artificial Lungs toward Portability

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