Evolution of geriatric Meniere's disease during the past two decades

Jeng, Yu-Jr; Young, Yi‐Ho

doi:10.1016/j.jfma.2022.08.007

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…Regarding Meniere’s disease, a 30 years epidemiologic and clinical study in Rochester showed that while there was no change in the annual incidence rate from 1951 through 1970, there was a slight decrease from 1971 through 1980 ( 15 ). Another smaller-scale study in Taiwan showed a declining incidence of Meniere’s disease ( 16 ), consistent with our study. The decline in Meniere’s disease may be due to trends of low-salt diet preference in developed countries where chronic diseases such as diabetes and hypertension are a major concern ( 17 ).…”

Section: Discussionsupporting

confidence: 92%

Trends in the incidence of peripheral vestibular disorders: a Nationwide population-based study

Hung,

Xirasagar,

Dang

et al. 2023

Front. Neurol.

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PurposeThis study aimed to examines the long-term trend of incidence of peripheral vestibular disorders between 2010 and 2018 in Taiwan.MethodsStudy-eligible patients were identified from Taiwan’s Longitudinal Health Insurance Database 2005 maintained by the Ministry of Health and Welfare in Taiwan. We retrieved 230,566 patients with a first-time diagnosis of peripheral vestibular disorders between 2010 and 2018. We calculated annual incidence rates of peripheral vestibular disorders per 100,000 population. We used the annual percent change (APC) to test the trend of peripheral vestibular disorders over time.ResultsThe mean annual incidence rate of peripheral vestibular disorders during the study period was 1489.6 per 100,000 population. Incidence showed a statistically significant steady decrease from 2010 to 2018 with a mean APC of −6.15% (95% CI = −6.97% ~ −5.32%). The decline was led by Meniere’s disease (APC = −9.83, 95% CI = −10.66% ~ −8.99%), followed by benign paroxysmal positional vertigo (APC = −3.69, 95% CI = −4.53% ~ −3.03%), vestibular neuritis (APC = −7.85, 95% CI = -8.96 ~ −6.73), and other peripheral vestibular dizziness (APC = −5.56, 95% CI = −6.69% ~ −4.43%).ConclusionThe incidence of peripheral vestibular disorders, overall, and the four major subgroups, benign paroxysmal positional vertigo, Meniere’s disease, vestibular neuritis, and other peripheral vestibular dizziness, all decreased substantially, year by year within the 2010–2018 period.

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Section: Discussionsupporting

confidence: 92%

Trends in the incidence of peripheral vestibular disorders: a Nationwide population-based study

Hung,

Xirasagar,

Dang

et al. 2023

Front. Neurol.

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“…Likewise, mean ages of Meniere's disease also increased. The incidence of Meniere's disease patients over 65 years also increased from 12.4% (2001–2010) to 18.2% (2011–2020), which is consistent with previous reports [6].…”

Section: Epidemiologysupporting

confidence: 92%

Epidemiology and genetics of Meniere's disease

Lopez-Escamez,

Liu

2023

Current Opinion in Neurology

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Purpose of review This review discusses the recent developments on the understanding of epidemiology and genetics of Meniere's disease. Recent findings Meniere's disease has been shown to be associated with several comorbidities, such as migraine, anxiety, allergy and immune disorders. Recent studies have investigated the relationship between environmental factors and Meniere's disease such as air pollution, allergy, asthma, osteoporosis or atmospheric pressure, reporting specific comorbidities in East Asian population. The application of exome sequencing has enabled the identification of genes sharing rare missense variants in multiple families with Meniere's disease, including OTOG and TECTA and suggesting digenic inheritance in MYO7A. Moreover, knockdown of DTNA gene orthologue in Drosophila resulted in defective proprioception and auditory function. DTNA and FAM136A knockout mice have been studied as potential mouse models for Meniere's disease. Summary While it has attracted emerging attention in recent years, the study of Meniere's disease genetics is still at its early stage. More geographically and ethnically based human genome studies, and the development of cellular and animal models of Meniere's disease may help shed light on the molecular mechanisms of Meniere's disease and provide the potential for gene-specific therapies.

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“…BPPV is the most common AV pathology, with: (i) a higher prevalence in the elderly compared to the younger population; and (ii) higher degrees of residual dizziness [ 24 ]. Endolymphatic hydrops represents the second most prevalent AV disorder in older adults [ 25 , 26 ]. In addition, as observed in presbyopia and presbyacusis cases, the aging processes affect the function of the peripheral vestibular system, causing a condition known as presbivestibulopathy.…”

Section: Discussionmentioning

confidence: 99%

Vertigo in the Elderly: A Systematic Literature Review

Fancello

Hatzopoulos

Santopietro

et al. 2023

JCM

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Background: Dizziness and vertigo are among the most prevalent complaints in the elderly and have a major negative influence on (i) the perception of the quality of life; and (ii) the risk of falling. Due to population aging, particularly in wealthy nations, vertigo represents a growing issue and a serious public health concern. In order to approach the patient correctly and to offer the best treatment options, it is mandatory to identify vertigo’s underlying causes. The aim of this paper was to identify the different etiologies of vertigo and possibly their frequency in the elderly population, by reviewing the scientific literature of the last decade (2012–2022). Methods: A systematic review was performed according to PRISMA guidelines, searching the Medline database from January 2012 through to December 2022. The search identified 1025 candidate papers, but after the application of specific selection criteria, only five were considered for further analysis. Results: A total of 2148 elderly patients (60–90 y old) presenting with vertigo were reported in the selected papers. A total of 3404 conditions were identified as the cause of vertiginous symptoms, (some patients presented multiple etiologies). All major diagnoses were categorized into different subgroups: the most common origin of vertigo was represented by audio-vestibular disorders (28.4%), followed by cardiovascular (20.4%) and neurological diseases (15.1%). Furthermore, 9.1% of patients were diagnosed with psychiatric conditions, whilst ophthalmologic and musculoskeletal disorders accounted for 7.5% and 6.3% of the cases respectively. Medication adverse effects and metabolic-related diseases were also considered among the causes. For 3.4% of cases the etiology remains unclear. Conclusions: Audio-vestibular disorders represent the most frequent cause of vertigo in the elderly. The etiologies affecting the vertigo patient must be defined in order to identify potential life-threatening conditions, such as cardiovascular and neurological disorders, which according to the data of this review constitute the second and third common causes of vertigo. A multidisciplinary strategy, involving different specialists (such as ENTs, Neurologists, Cardiologists, Geriatricians) is recommended for the correct assessment of these disorders.

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Evolution of geriatric Meniere's disease during the past two decades

Cited by 7 publications

References 21 publications

Trends in the incidence of peripheral vestibular disorders: a Nationwide population-based study

Trends in the incidence of peripheral vestibular disorders: a Nationwide population-based study

Epidemiology and genetics of Meniere's disease

Vertigo in the Elderly: A Systematic Literature Review

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