“…Gold, usually as the metal, is perhaps the most anciently administered medicine (1) Gold nanoparticles have been in active use in the identification of chemical and biological agent, Gold has been exploited for its putative medical properties throughout the history of civilisation. (2) Gold has many application in Jewellery, Electronics ,Cuisine Miscellanea and medicine (3) One of the new application of the gold is consider as a Methods to enhance fracture healing which is an important way to ensure the patients rapid recovery, as Autologous bone grafting, the current "gold-standard" in the enhancement of fracture repair, is costly, timeconsuming, and associated with morbidity including pain, injury, hematoma, and fracture . (4) Hydroxyapatite (HA), is an important inorganic biomaterial consisting of calcium and phosphorous which are important minerals found in human bone (5) Hydroxyapatite can either be synthesized from the natural organic based materials or inorganic components.…”