Evolution of hormone-phenotype couplings and hormone-genome interactions

Cox, Robert M.; Hale, Matthew D.; Wittman, Tyler N; Robinson, Christopher D.; Cox, Christian L.

doi:10.1016/j.yhbeh.2022.105216

Cited by 10 publications

(4 citation statements)

References 94 publications

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“…Hence, it seems plausible that genetic variation underlying different hormonal profiles within sexes is a key component in the evolution of distinct reproductive phenotypes within species. Divergent co-evolution of such distinct traits can be facilitated by hormonal pleiotropy (Cox, 2020;Cox, Hale, Wittman, Robinson, & Cox, 2022;Wittman et al, 2021) and by the fact that sex steroids mediate the investment into life-history trade-offs (Hau, 2007;Hau & Wingfield, 2011). Genetic and physiological regulatory axes are functionally linked to steroids (Cox, McGlothlin, & Bonier, 2016;Hau & Wingfield, 2011), thus chromosomal rearrangements that capture steroid-related genes can exert large pleiotropic effects while still maintaining phenotypic integrity.…”

Section: Discussionmentioning

confidence: 99%

A supergene affects steroid metabolism during early ontogeny in a bird with alternative reproductive morphs

Giraldo‐Deck

Loveland

Goymann

et al. 2022

Preprint

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Reproductive phenotypes are shaped by genetic, physiological and environmental variation that an organism experiences during ontogeny. Steroid hormones play an integrative role in this process through both genomic and non-genomic pathways. Differences in steroid hormone metabolism may be rooted in genomic variation. Here we evaluate the influence of supergene variants underlying alternative reproductive tactics on sex steroid metabolism during ontogeny in ruffs (Calidris pugnax). Adult ruff males exhibit three male mating morphs called Independents, Faeders and Satellites, that differ prominently in circulating androgen (testosterone and androstenedione) concentrations. Across morphs and sexes chicks showed similar mean androgen concentrations during ontogenetic development. However, variances in circulating androgens showed the same pattern as corresponding variances previously observed in adults. HSD17B2 had been previously identified as a key gene for mediating differences in androgen levels between morphs as it encodes the enzyme that converts testosterone to androstenedione and is located within the supergene. Observed HSD17B2 expression in embryonic brain tissue was consistent with predictions based on genetic and endocrine differences. Taken together, the observed differences in circulating androgen concentrations and gene expression point to testosterone synthesis as a key mechanism that shapes developmental trajectories and differences in brain organization among morphs.

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Section: Discussionmentioning

confidence: 99%

A supergene affects steroid metabolism during early ontogeny in a bird with alternative reproductive morphs

Giraldo‐Deck

Loveland

Goymann

et al. 2022

Preprint

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show abstract

“…Moreover, there are multiple places in the complex control of hormonal pathways where genetic variation could exist and so respond to selection, but the extent of variation may vary, thereby putting constraints on some kinds of potential changes [69][70][71]. Endocrine mechanisms also have the capacity to impact an individual trait or influence suites of related traits, causing their phenotypic outcomes to be diverse [13,71].…”

Section: Endocrine Mechanisms and Climate Changementioning

confidence: 99%

“…However, the actions of endocrine mechanisms can be complex and difficult to predict because changes in hormone levels and receptor densities can be mediated by genetics, plasticity or both [13,67] and these differentially affect opportunities for and responses to selection [68]. Moreover, there are multiple places in the complex control of hormonal pathways where genetic variation could exist and so respond to selection, but the extent of variation may vary, thereby putting constraints on some kinds of potential changes [69–71]. Endocrine mechanisms also have the capacity to impact an individual trait or influence suites of related traits, causing their phenotypic outcomes to be diverse [13,71].…”

Section: Endocrine Mechanisms and Climate Changementioning

confidence: 99%

“…In the context of climate change, this example illustrates the potential for other hormones or epigenetic modifiers to interact with the GH/IGF axis and exert coordinated effects on body size through the integration of hormonal mechanisms. Because the GH/IGF axis coordinates a high degree of hormonal pleiotropy and the effects that it exerts on body size are often (though not always) difficult to reverse, we might predict that selection should favour changes in the sensitivity of particular tissues to hormones in the axis, rather than changes in hormone levels themselves [71].…”

Section: Endocrine Mechanisms and Climate Changementioning

confidence: 99%

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Climate change and its effects on body size and shape: the role of endocrine mechanisms

Names,

Grindstaff,

Westneat

et al. 2024

Phil. Trans. R. Soc. B

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In many organisms, rapidly changing environmental conditions are inducing dramatic shifts in diverse phenotypic traits with consequences for fitness and population viability. However, the mechanisms that underlie these responses remain poorly understood. Endocrine signalling systems often influence suites of traits and are sensitive to changes in environmental conditions; they are thus ideal candidates for uncovering both plastic and evolved consequences of climate change. Here, we use body size and shape, a set of integrated traits predicted to shift in response to rising temperatures with effects on fitness, and insulin-like growth factor-1 as a case study to explore these ideas. We review what is known about changes in body size and shape in response to rising temperatures and then illustrate why endocrine signalling systems are likely to be critical in mediating these effects. Lastly, we discuss research approaches that will advance understanding of the processes that underlie rapid responses to climate change and the role endocrine systems will have. Knowledge of the mechanisms involved in phenotypic responses to climate change will be essential for predicting both the ecological and the long-term evolutionary consequences of a warming climate. This article is part of the theme issue ‘Endocrine responses to environmental variation: conceptual approaches and recent developments’.

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Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies

Song,

Zhang,

Zhang

et al. 2024

Genes & Diseases

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Evolution of hormone-phenotype couplings and hormone-genome interactions

Cited by 10 publications

References 94 publications

A supergene affects steroid metabolism during early ontogeny in a bird with alternative reproductive morphs

A supergene affects steroid metabolism during early ontogeny in a bird with alternative reproductive morphs

Climate change and its effects on body size and shape: the role of endocrine mechanisms

Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies

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