Evolution of implants and advancements for osseointegration: A narrative review

Walter, Nike; Stich, Theresia; Docheva, Denitsa; Alt, Volker; Rupp, Markus

doi:10.1016/j.injury.2022.05.057

Cited by 24 publications

(9 citation statements)

References 44 publications

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“…Osteointegration depends on the biocompatibility, physical, mechanical, and topological characteristics of biomaterials and is critical for implant stability and clinical long-term success [7]. Moreover, implant osteointegration is a complex process that cannot be reduced to the mere growth of new bone in direct contact with the implant and according to its shape, but it also requires compliance with specific mechanical aspects to guarantee implant stability and to avoid relative micromotion with adjacent tissues under functional loads [8,9].…”

Section: Introductionmentioning

confidence: 99%

An Advanced Human Bone Tissue Culture Model for the Assessment of Implant Osteointegration In Vitro

Maglio,

Fini,

Sartori

et al. 2024

IJMS

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In the field of biomaterials for prosthetic reconstructive surgery, there is the lack of advanced innovative methods to investigate the potentialities of smart biomaterials before in vivo tests. Despite the complex osteointegration process being difficult to recreate in vitro, this study proposes an advanced in vitro tissue culture model of osteointegration using human bone. Cubic samples of trabecular bone were harvested, as waste material, from hip arthroplasty; inner cylindrical defects were created and assigned to the following groups: (1) empty defects (CTRneg); (2) defects implanted with a cytotoxic copper pin (CTRpos); (3) defects implanted with standard titanium pins (Ti). Tissues were dynamically cultured in mini rotating bioreactors and assessed weekly for viability and sterility. After 8 weeks, immunoenzymatic, microtomographic, histological, and histomorphometric analyses were performed. The model was able to simulate the effects of implantation of the materials, showing a drop in viability in CTR+, while Ti appears to have a trophic effect on bone. MicroCT and a histological analysis supported the results, with signs of matrix and bone deposition at the Ti implant site. Data suggest the reliability of the tested model in recreating the osteointegration process in vitro with the aim of reducing and refining in vivo preclinical models.

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Section: Introductionmentioning

confidence: 99%

An Advanced Human Bone Tissue Culture Model for the Assessment of Implant Osteointegration In Vitro

Maglio,

Fini,

Sartori

et al. 2024

IJMS

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“…This requires the differentiation of progenitor cells into osteoblasts which later become osteocytes embedded in the mineralized matrix. During osseointegration, osteoprogenitor cells and vessels grow and osteoblasts adhere to the implant surface [ 4 ]. Therefore, the ability to promote the rapid and effective attachment of the osteoblasts is crucial.…”

Section: Introductionmentioning

confidence: 99%

Cold Atmospheric Plasma Improves the Colonization of Titanium with Primary Human Osteoblasts: An In Vitro Study

Gund,

Naim,

Lehmann

et al. 2024

Biomedicines

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Several studies have shown that cold atmospheric plasma (CAP) treatment can favourably modify titanium surfaces to promote osteoblast colonization. The aim of this study was to investigate the initial attachment of primary human osteoblasts to plasma-treated titanium. Micro-structured titanium discs were treated with cold atmospheric plasma followed by the application of primary human osteoblasts. The microwave plasma source used in this study uses helium as a carrier gas and was developed at the Leibniz Institute for Surface Modification in Leipzig, Germany. Primary human osteoblasts were analyzed by fluorescence and cell biological tests (alkaline phosphatase activity and cell proliferation using WST-1 assay). The tests were performed after 4, 12, and 24 h and showed statistically significant increased levels of cell activity after plasma treatment. The results of this study indicate that plasma treatment improves the initial attachment of primary human osteoblasts to titanium. For the first time, the positive effect of cold atmospheric plasma treatment of micro-structured titanium on the initial colonization with primary human osteoblasts has been demonstrated. Overall, this study demonstrates the excellent biocompatibility of micro-structured titanium. The results of this study support efforts to use cold atmospheric plasmas in implantology, both for preimplantation conditioning and for regeneration of lost attachment due to peri-implantitis.

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“…There has been a lot of research going on in the field of biomaterials to find the right combination of materials that could exactly mimic the natural tissue response upon implantation, providing a successful regeneration of the damaged tissue . Biomaterials can be made from a wide range of materials, including metals, polymers, ceramics, and natural substances, such as bone and collagen . Some examples of materials used as bone implants are metallic implants, of which the most common metals used are Fe, Ni, Cr, Mn, Ti, and their intermixed alloys.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of a Titanium-Based Functionally Graded Material-Structured Biocomposite using Powder Metallurgy

Ul Haq,

Ahmed,

U Rehman

et al. 2023

ACS Omega

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This investigation aims at synthesizing and characterizing a biocomposite of hydroxyapatite (HA) and titanium (Ti) as a functionally graded material (FGM) via an economical powder metallurgy route. Ti particles were produced through drilling and chipping, followed by compaction and sintering. Ti foams, so obtained, were then infused with varying volume fractions of HA. The pure Ti foam control sample and the FGM composite samples were then subjected to various characterizations to validate their biocompatibility, structural strength, and integrity. The interface development between the load-bearing Ti implant and living tissue was resolved through an FGM structure, where the base of the implant consisted of load-bearing Ti and the outer periphery changed to HA gradually. HA/Ti specimens of different volume fractions were tested for density measurements, microstructure, hardness, and bioactivity. The bioactive behavior was investigated using the potentiodynamic polarization technique to measure the corrosion rate of the pure Ti foam (0/100 HA/Ti) and the FGM composite (10/90 HA/Ti) samples in a simulated body fluid (SBF). The results showed that the hardness of FGM composites, despite being less than that of 0/100 HA/Ti, was still within safe limits. The corrosion rate, however, was found to be decreased by a significant value of almost 40% for the 10/90 HA/Ti FGM composite sample compared to the pure Ti foam control sample. It was concluded that the optimum composition 10/90 HA/Ti sample offers improved corrosion resistance while maintaining a sufficient allowable hardness level.

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Evolution of implants and advancements for osseointegration: A narrative review

Cited by 24 publications

References 44 publications

An Advanced Human Bone Tissue Culture Model for the Assessment of Implant Osteointegration In Vitro

An Advanced Human Bone Tissue Culture Model for the Assessment of Implant Osteointegration In Vitro

Cold Atmospheric Plasma Improves the Colonization of Titanium with Primary Human Osteoblasts: An In Vitro Study

Synthesis and Characterization of a Titanium-Based Functionally Graded Material-Structured Biocomposite using Powder Metallurgy

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